{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T03:55:15Z","timestamp":1778644515558,"version":"3.51.4"},"reference-count":82,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T00:00:00Z","timestamp":1502928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1006421","type":"journal-article","created":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T17:40:17Z","timestamp":1502991617000},"page":"e1006421","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":83,"title":["Experimental study of tuberculosis: From animal models to complex cell systems and organoids"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7048-9740","authenticated-orcid":true,"given":"Kaori L.","family":"Fonseca","sequence":"first","affiliation":[]},{"given":"Pedro N. S.","family":"Rodrigues","sequence":"additional","affiliation":[]},{"given":"I. Anna S.","family":"Olsson","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8180-1293","authenticated-orcid":true,"given":"Margarida","family":"Saraiva","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2017,8,17]]},"reference":[{"key":"ref1","unstructured":"WHO. Global Tuberculosis Report. 2016."},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1183\/09031936.00204611","article-title":"Tuberculosis: cost of illness in Germany","volume":"40","author":"R Diel","year":"2012","journal-title":"Eur Respir J"},{"issue":"9979","key":"ref3","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1016\/S0140-6736(15)60570-0","article-title":"WHO&apos;s new End TB Strategy","volume":"385","author":"M Uplekar","year":"2015","journal-title":"The Lancet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1146\/annurev-publhealth-031912-114431","article-title":"Prospects for tuberculosis elimination","volume":"34","author":"C Dye","year":"2013","journal-title":"Annu Rev Public Health"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"e1001965","DOI":"10.1371\/journal.pmed.1001965","article-title":"Translational Research for Tuberculosis Elimination: Priorities, Challenges, and Actions","volume":"13","author":"C Lienhardt","year":"2016","journal-title":"PLoS Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"16076","DOI":"10.1038\/nrdp.2016.76","article-title":"Tuberculosis","volume":"2","author":"M Pai","year":"2016","journal-title":"Nat Rev Dis Primers"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/imr.12270","article-title":"Tuberculosis vaccines: barriers and prospects on the quest for a transformative tool","volume":"264","author":"CL Karp","year":"2015","journal-title":"Immunol Rev"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1146\/annurev-immunol-032712-095939","article-title":"The immune response in tuberculosis","volume":"31","author":"A O'Garra","year":"2013","journal-title":"Annu Rev Immunol"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/ni.3048","article-title":"The balance between protective and pathogenic immune responses in the TB-infected lung","volume":"16","author":"IM Orme","year":"2015","journal-title":"Nat Immunol"},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s00281-015-0531-3","article-title":"Pathology and immune reactivity: understanding multidimensionality in pulmonary tuberculosis","volume":"38","author":"A Dorhoi","year":"2016","journal-title":"Semin Immunopathol"},{"issue":"3","key":"ref11","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S1471-4914(00)01901-8","article-title":"Disease model: pulmonary tuberculosis","volume":"7","author":"DN McMurray","year":"2001","journal-title":"Trends in molecular medicine"},{"issue":"8","key":"ref12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1517\/17460441.2015.1049529","article-title":"Animal models in tuberculosis research\u2014where is the beef?","volume":"10","author":"H Myllymaki","year":"2015","journal-title":"Expert Opin Drug Discov"},{"issue":"1\u20133","key":"ref13","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S1472-9792(02)00069-0","article-title":"The mouse as a useful model of tuberculosis","volume":"83","author":"IM Orme","year":"2003","journal-title":"Tuberculosis"},{"issue":"5\u20136","key":"ref14","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.tube.2005.08.008","article-title":"Animal models of tuberculosis","volume":"85","author":"UD Gupta","year":"2005","journal-title":"Tuberculosis [Edinb]"},{"issue":"2","key":"ref15","doi-asserted-by":"crossref","first-page":"a018556","DOI":"10.1101\/cshperspect.a018556","article-title":"Mouse Model of Tuberculosis","volume":"5","author":"AM Cooper","year":"2015","journal-title":"Cold Spring Harb Perspect Med"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3389\/fmicb.2014.00055","article-title":"The lack of a big picture in tuberculosis: the clinical point of view, the problems of experimental modeling and immunomodulation. The factors we should consider when designing novel treatment strategies","volume":"5","author":"C Vilaplana","year":"2014","journal-title":"Front Microbiol"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s00281-015-0538-9","article-title":"Mouse models of human TB pathology: roles in the analysis of necrosis and the development of host-directed therapies","volume":"38","author":"I Kramnik","year":"2016","journal-title":"Semin Immunopathol"},{"issue":"5","key":"ref18","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01516-16","article-title":"Tuberculosis Susceptibility and Vaccine Protection Are Independently Controlled by Host Genotype","volume":"7","author":"CM Smith","year":"2016","journal-title":"MBio"},{"issue":"10","key":"ref19","doi-asserted-by":"crossref","first-page":"e47723","DOI":"10.1371\/journal.pone.0047723","article-title":"Animal welfare in studies on murine tuberculosis: assessing progress over a 12-year period and the need for further improvement","volume":"7","author":"NH Franco","year":"2012","journal-title":"PLoS ONE"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"e1002399","DOI":"10.1371\/journal.ppat.1002399","article-title":"How &quot;humane&quot; is your endpoint? Refining the science-driven approach for termination of animal studies of chronic infection","volume":"8","author":"NH Franco","year":"2012","journal-title":"PLoS Pathog"},{"issue":"4","key":"ref21","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.4049\/jimmunol.176.4.2053","article-title":"Experimental Models to Study Development and Function of the Human Immune System In Vivo","volume":"176","author":"N Legrand","year":"2006","journal-title":"The Journal of Immunology"},{"issue":"5","key":"ref22","doi-asserted-by":"crossref","first-page":"e63331","DOI":"10.1371\/journal.pone.0063331","article-title":"A Humanized Mouse Model of Tuberculosis","volume":"8","author":"VE Calderon","year":"2013","journal-title":"PLoS ONE"},{"issue":"16","key":"ref23","doi-asserted-by":"crossref","first-page":"6482","DOI":"10.1073\/pnas.1219985110","article-title":"CD4+ cell-dependent granuloma formation in humanized mice infected with mycobacteria","volume":"110","author":"F Heuts","year":"2013","journal-title":"PNAS"},{"issue":"53","key":"ref24","article-title":"Engrafted human cells generate adaptive immune responses to Mycobacterium bovis BCG infection in humanized mice","volume":"14","author":"J Lee","year":"2013","journal-title":"BMC Immunology"},{"key":"ref25","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.08525","article-title":"Mycolic acid-specific T cells protect against Mycobacterium tuberculosis infection in a humanized transgenic mouse model","volume":"4","author":"J Zhao","year":"2015","journal-title":"Elife"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"21522","DOI":"10.1038\/srep21522","article-title":"Pulmonary Tuberculosis in Humanized Mice Infected with HIV-1","volume":"6","author":"RJ Nusbaum","year":"2016","journal-title":"Sci Rep"},{"key":"ref27","article-title":"Mycobacterial Infections in Rabbits: From the Wild to the Laboratory","author":"R Arrazuria","year":"2016","journal-title":"Transbound Emerg Dis"},{"issue":"5","key":"ref28","doi-asserted-by":"crossref","first-page":"a018572","DOI":"10.1101\/cshperspect.a018572","article-title":"Animal models of tuberculosis: Guinea pigs","volume":"5","author":"S Clark","year":"2014","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"12","key":"ref29","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.molmed.2012.10.002","article-title":"Insights into tuberculosis from the zebrafish model","volume":"18","author":"RD Berg","year":"2012","journal-title":"Trends Mol Med"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"196","DOI":"10.3389\/fimmu.2016.00196","article-title":"The Zebrafish Breathes New Life into the Study of Tuberculosis","volume":"7","author":"H Myllymaki","year":"2016","journal-title":"Front Immunol"},{"issue":"2","key":"ref31","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s00281-015-0522-4","article-title":"Protection and pathology in TB: learning from the zebrafish model","volume":"38","author":"AH Meijer","year":"2016","journal-title":"Semin Immunopathol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1101\/sqb.2013.78.023283","article-title":"The zebrafish guide to tuberculosis immunity and treatment","volume":"78","author":"L Ramakrishnan","year":"2013","journal-title":"Cold Spring Harb Symp Quant Biol"},{"issue":"5","key":"ref33","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.cell.2010.02.013","article-title":"The lta4h locus modulates susceptibility to mycobacterial infection in zebrafish and humans","volume":"140","author":"DM Tobin","year":"2010","journal-title":"Cell"},{"issue":"4","key":"ref34","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.immuni.2016.09.014","article-title":"Macrophage Epithelial Reprogramming Underlies Mycobacterial Granuloma Formation and Promotes Infection","volume":"45","author":"MR Cronan","year":"2016","journal-title":"Immunity"},{"issue":"1\u20133","key":"ref35","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/S1472-9792(02)00059-8","article-title":"Non-human primates: a model for tuberculosis research","volume":"83","author":"JL Flynn","year":"2003","journal-title":"Tuberculosis"},{"issue":"12","key":"ref36","doi-asserted-by":"crossref","first-page":"a018564","DOI":"10.1101\/cshperspect.a018564","article-title":"Modeling tuberculosis in nonhuman primates","volume":"4","author":"CA Scanga","year":"2014","journal-title":"Cold Spring Harb Perspect Med"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/imr.12258","article-title":"Immunology studies in non-human primate models of tuberculosis","volume":"264","author":"JL Flynn","year":"2015","journal-title":"Immunol Rev"},{"issue":"10","key":"ref38","doi-asserted-by":"crossref","first-page":"5831","DOI":"10.1128\/IAI.71.10.5831-5844.2003","article-title":"Experimental Mycobacterium tuberculosis Infection of Cynomolgus Macaques Closely Resembles the Various Manifestations of Human M. tuberculosis Infection","volume":"71","author":"SV Capuano","year":"2003","journal-title":"Infect Immun"},{"issue":"4","key":"ref39","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1600-0684.2011.00485.x","article-title":"Reactivation of latent tuberculosis in rhesus macaques by coinfection with simian immunodeficiency virus","volume":"40","author":"S Mehra","year":"2011","journal-title":"J Med Primatol"},{"issue":"2","key":"ref40","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1002\/art.27271","article-title":"Tumor necrosis factor neutralization results in disseminated disease in acute and latent Mycobacterium tuberculosis infection with normal granuloma structure in a cynomolgus macaque model","volume":"62","author":"PL Lin","year":"2010","journal-title":"Arthritis Rheum"},{"issue":"12","key":"ref41","doi-asserted-by":"crossref","first-page":"4817","DOI":"10.4049\/jimmunol.1601138","article-title":"Early Whole Blood Transcriptional Signatures Are Associated with Severity of Lung Inflammation in Cynomolgus Macaques with Mycobacterium tuberculosis Infection","volume":"197","author":"HP Gideon","year":"2016","journal-title":"J Immunol"},{"issue":"3","key":"ref42","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1128\/IAI.02850-14","article-title":"Monkey models of tuberculosis: lessons learned","volume":"83","author":"JC Pena","year":"2015","journal-title":"Infect Immun"},{"issue":"12","key":"ref43","article-title":"Innate and Adaptive Cellular Immune Responses to Mycobacterium tuberculosis Infection","volume":"5","author":"KD Mayer-Barber","year":"2015","journal-title":"Cold Spring Harb Perspect Med"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/imr.12254","article-title":"Trans-species communication in the Mycobacterium tuberculosis-infected macrophage","volume":"264","author":"S Tan","year":"2015","journal-title":"Immunol Rev"},{"issue":"2","key":"ref45","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1128\/IAI.72.2.1169-1173.2004","article-title":"Activated THP-1 Cells: an Attractive Model for the Assessment of Intracellular Growth Rates of Mycobacterium tuberculosis Isolates","volume":"72","author":"SA Theus","year":"2004","journal-title":"Infect Immun"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3389\/fmicb.2011.00067","article-title":"A Novel in vitro Human Macrophage Model to Study the Persistence of Mycobacterium tuberculosis Using Vitamin D[3] and Retinoic Acid Activated THP-1 Macrophages","volume":"2","author":"JL Estrella","year":"2011","journal-title":"Front Microbiol"},{"issue":"3","key":"ref47","doi-asserted-by":"crossref","first-page":"e1001307","DOI":"10.1371\/journal.ppat.1001307","article-title":"Human macrophage responses to clinical isolates from the Mycobacterium tuberculosis complex discriminate between ancient and modern lineages","volume":"7","author":"D Portevin","year":"2011","journal-title":"PLoS Pathog"},{"issue":"10","key":"ref48","doi-asserted-by":"crossref","first-page":"3889","DOI":"10.1172\/JCI57235","article-title":"In vitro differentiation of human macrophages with enhanced antimycobacterial activity","volume":"121","author":"G Vogt","year":"2011","journal-title":"J Clin Invest"},{"issue":"9","key":"ref49","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1038\/ni.1781","article-title":"Foamy macrophages and the progression of the human tuberculosis granuloma","volume":"10","author":"DG Russell","year":"2009","journal-title":"Nat Immunol"},{"issue":"6","key":"ref50","doi-asserted-by":"crossref","first-page":"e1002093","DOI":"10.1371\/journal.ppat.1002093","article-title":"Mycobacterium tuberculosis uses host triacylglycerol to accumulate lipid droplets and acquires a dormancy-like phenotype in lipid-loaded macrophages","volume":"7","author":"J Daniel","year":"2011","journal-title":"PLoS Pathog"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"122","DOI":"10.3389\/fcimb.2016.00122","article-title":"Experimental Models of Foamy Macrophages and Approaches for Dissecting the Mechanisms of Lipid Accumulation and Consumption during Dormancy and Reactivation of Tuberculosis","volume":"6","author":"P Santucci","year":"2016","journal-title":"Front Cell Infect Microbiol"},{"issue":"12","key":"ref52","doi-asserted-by":"crossref","first-page":"4727","DOI":"10.4049\/jimmunol.1600856","article-title":"CD36-Mediated Uptake of Surfactant Lipids by Human Macrophages Promotes Intracellular Growth of Mycobacterium tuberculosis","volume":"197","author":"CE Dodd","year":"2016","journal-title":"J Immunol"},{"issue":"10","key":"ref53","doi-asserted-by":"crossref","first-page":"e13594","DOI":"10.1371\/journal.pone.0013594","article-title":"Innate immune response to Mycobacterium tuberculosis Beijing and other genotypes","volume":"5","author":"C Wang","year":"2010","journal-title":"PLoS ONE"},{"issue":"5","key":"ref54","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1111\/j.1462-5822.2004.00371.x","article-title":"An in vitro dual model of mycobacterial granulomas to investigate the molecular interactions between mycobacteria and human host cells","volume":"6","author":"MP Puissegur","year":"2004","journal-title":"Cell Microbiol"},{"issue":"11","key":"ref55","doi-asserted-by":"crossref","first-page":"e1000204","DOI":"10.1371\/journal.ppat.1000204","article-title":"Foamy macrophages from tuberculous patients&apos; granulomas constitute a nutrient-rich reservoir for M. tuberculosis persistence","volume":"4","author":"P Peyron","year":"2008","journal-title":"PLoS Pathog"},{"issue":"1","key":"ref56","doi-asserted-by":"crossref","first-page":"e02537","DOI":"10.1128\/mBio.02537-14","article-title":"Characterization of host and microbial determinants in individuals with latent tuberculosis infection using a human granuloma model","volume":"6","author":"E Guirado","year":"2015","journal-title":"MBio"},{"issue":"8","key":"ref57","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1002\/eji.201646349","article-title":"Isoniazid-induced control of Mycobacterium tuberculosis by primary human cells requires interleukin-1 receptor and tumor necrosis factor","volume":"46","author":"LH Yamashiro","year":"2016","journal-title":"Eur J Immunol"},{"issue":"1","key":"ref58","doi-asserted-by":"crossref","first-page":"e53657","DOI":"10.1371\/journal.pone.0053657","article-title":"Human granuloma in vitro model, for TB dormancy and resuscitation","volume":"8","author":"N Kapoor","year":"2013","journal-title":"PLoS ONE"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"e21283","DOI":"10.7554\/eLife.21283","article-title":"Dissection of the host-pathogen interaction in human tuberculosis using a bioengineered 3-dimensional model","volume":"6","author":"LB Tezera","year":"2017","journal-title":"Elife"},{"issue":"1","key":"ref60","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1128\/IAI.70.1.140-146.2002","article-title":"The Efficiency of the Translocation of Mycobacterium tuberculosis across a Bilayer of Epithelial and Endothelial Cells as a Model of the Alveolar Wall Is a Consequence of Transport within Mononuclear Phagocytes and Invasion of Alveolar Epithelial Cells","volume":"70","author":"LE Bermudez","year":"2002","journal-title":"Infection and Immunity"},{"issue":"2","key":"ref61","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1128\/IAI.67.2.653-658.1999","article-title":"An In Vitro Tissue Culture Bilayer Model To Examine Early Events in Mycobacterium tuberculosis Infection","volume":"67","author":"KA Birkness","year":"1999","journal-title":"Infect Immun"},{"issue":"5","key":"ref62","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.celrep.2016.06.080","article-title":"Microfold Cells Actively Translocate Mycobacterium tuberculosis to Initiate Infection","volume":"16","author":"VR Nair","year":"2016","journal-title":"Cell Rep"},{"issue":"2","key":"ref63","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1242\/dmm.013854","article-title":"Modeling Mycobacterium tuberculosis early granuloma formation in experimental human lung tissue","volume":"7","author":"VR Parasa","year":"2014","journal-title":"Dis Model Mech"},{"issue":"104","key":"ref64","doi-asserted-by":"crossref","DOI":"10.3791\/53084","article-title":"A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection","author":"C Braian","year":"2015","journal-title":"J Vis Exp"},{"issue":"1","key":"ref65","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02073-16","article-title":"A Bioengineered Three-Dimensional Cell Culture Platform Integrated with Microfluidics To Address Antimicrobial Resistance in Tuberculosis","volume":"8","author":"MK Bielecka","year":"2017","journal-title":"MBio"},{"issue":"4","key":"ref66","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.tim.2017.02.009","article-title":"Bioengineered 3D Models for Studying Human Cell-Tuberculosis Interactions","volume":"25","author":"S Benmerzoug","year":"2017","journal-title":"Trends Microbiol"},{"issue":"1","key":"ref67","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1159\/000439275","article-title":"Alveolar Epithelial Cells in Mycobacterium tuberculosis Infection: Active Players or Innocent Bystanders?","volume":"8","author":"JM Scordo","year":"2016","journal-title":"J Innate Immun"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ijid.2015.01.016","article-title":"Cellular therapy in tuberculosis","volume":"32","author":"SK Parida","year":"2015","journal-title":"Int J Infect Dis"},{"issue":"7","key":"ref69","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1016\/j.cell.2016.05.082","article-title":"Modeling Development and Disease with Organoids","volume":"165","author":"H Clevers","year":"2016","journal-title":"Cell"},{"issue":"3","key":"ref70","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/ncb3312","article-title":"Organoids as an in vitro model of human development and disease","volume":"18","author":"A Fatehullah","year":"2016","journal-title":"Nat Cell Biol"},{"key":"ref71","article-title":"Physiologically relevant human tissue models for infectious diseases","author":"M Mills","year":"2016","journal-title":"Drug Discov Today"},{"issue":"7531","key":"ref72","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/nature13863","article-title":"Modelling human development and disease in pluripotent stem-cell-derived gastric organoids","volume":"516","author":"KW McCracken","year":"2014","journal-title":"Nature"},{"issue":"7467","key":"ref73","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/nature12517","article-title":"Cerebral organoids model human brain development and microcephaly","volume":"501","author":"MA Lancaster","year":"2013","journal-title":"Nature"},{"issue":"6","key":"ref74","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.stem.2016.11.014","article-title":"Advances in Zika Virus Research: Stem Cell Models, Challenges, and Opportunities","volume":"19","author":"GL Ming","year":"2016","journal-title":"Cell Stem Cell"},{"issue":"1","key":"ref75","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1128\/IAI.02561-14","article-title":"Persistence and toxin production by Clostridium difficile within human intestinal organoids result in disruption of epithelial paracellular barrier function","volume":"83","author":"JL Leslie","year":"2015","journal-title":"Infect Immun"},{"issue":"4","key":"ref76","doi-asserted-by":"crossref","first-page":"e00159","DOI":"10.1128\/mBio.00159-12","article-title":"Stem cell-derived human intestinal organoids as an infection model for rotaviruses","volume":"3","author":"SR Finkbeiner","year":"2012","journal-title":"MBio"},{"issue":"3","key":"ref77","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.bbrc.2015.12.091","article-title":"Organoids as a model system for studying human lung development and disease","volume":"473","author":"RR Nadkarni","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"key":"ref78","article-title":"In vitro generation of human pluripotent stem cell derived lung organoids","volume":"4","author":"BR Dye","year":"2015","journal-title":"Elife"},{"issue":"1","key":"ref79","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.stemcr.2015.11.010","article-title":"Directed Induction of Functional Multi-ciliated Cells in Proximal Airway Epithelial Spheroids from Human Pluripotent Stem Cells","volume":"6","author":"S Konishi","year":"2016","journal-title":"Stem Cell Reports"},{"key":"ref80","article-title":"A bioengineered niche promotes in vivo engraftment and maturation of pluripotent stem cell derived human lung organoids","volume":"5","author":"BR Dye","year":"2016","journal-title":"Elife"},{"issue":"17","key":"ref81","doi-asserted-by":"crossref","first-page":"3349","DOI":"10.1039\/C4LC00552J","article-title":"A biomimetic multicellular model of the airways using primary human cells","volume":"14","author":"KL Sellgren","year":"2014","journal-title":"Lab Chip"},{"issue":"2","key":"ref82","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/nmeth.3697","article-title":"Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro","volume":"13","author":"KH Benam","year":"2016","journal-title":"Nat Methods"}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1006421","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T10:03:03Z","timestamp":1719396183000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1006421"}},"subtitle":[],"editor":[{"given":"James B.","family":"Bliska","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2017,8,17]]},"references-count":82,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2017,8,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1006421","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,17]]}}}