{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:28:30Z","timestamp":1770748110604,"version":"3.49.0"},"update-to":[{"DOI":"10.1371\/journal.ppat.1008311","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T00:00:00Z","timestamp":1582243200000}}],"reference-count":58,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T00:00:00Z","timestamp":1581292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sociedad Espa\u00f1ola de Enfermedades Infecciosas y Microbiolog\u00eda Clinica"},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BPD\/91623\/2012"],"award-info":[{"award-number":["SFRH\/BPD\/91623\/2012"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Programa JUAN DE LA CIERVA","award":["MINECO, IJCI-2016-29524"],"award-info":[{"award-number":["MINECO, IJCI-2016-29524"]}]},{"name":"Sociedad Espa\u00f1ola de Enfermedades Infecciosas y Microbiolog\u00eda Clinica"},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI15\/00860"],"award-info":[{"award-number":["PI15\/00860"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI18\/00501"],"award-info":[{"award-number":["PI18\/00501"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1008311","type":"journal-article","created":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T13:34:50Z","timestamp":1581341690000},"page":"e1008311","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":27,"title":["A live auxotrophic vaccine confers mucosal immunity and protection against lethal pneumonia caused by Pseudomonas aeruginosa"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7119-440X","authenticated-orcid":true,"given":"Maria P.","family":"Cabral","sequence":"first","affiliation":[]},{"given":"Alexandra","family":"Correia","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7007-306X","authenticated-orcid":true,"given":"Manuel","family":"Vilanova","sequence":"additional","affiliation":[]},{"given":"F\u00e1tima","family":"G\u00e4rtner","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8977-3269","authenticated-orcid":true,"given":"Miriam","family":"Moscoso","sequence":"additional","affiliation":[]},{"given":"Patricia","family":"Garc\u00eda","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7581-8654","authenticated-orcid":true,"given":"Juan A.","family":"Vallejo","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1809-3332","authenticated-orcid":true,"given":"Astrid","family":"P\u00e9rez","sequence":"additional","affiliation":[]},{"given":"M\u00f3nica","family":"Francisco-Tom\u00e9","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1827-7003","authenticated-orcid":true,"given":"V\u00edctor","family":"Fuentes-Valverde","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8837-0062","authenticated-orcid":true,"given":"Germ\u00e1n","family":"Bou","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2020,2,10]]},"reference":[{"issue":"1","key":"ppat.1008311.ref001","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1186\/1471-2334-13-561","article-title":"A comparison of microbiology and demographics among patients with healthcare-associated, hospital-acquired, and ventilator-associated pneumonia: a retrospective analysis of 1184 patients from a large, international study","volume":"13","author":"AA Quartin","year":"2013","journal-title":"BMC Infect Dis"},{"issue":"3","key":"ppat.1008311.ref002","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0002-9343(93)90060-3","article-title":"Nosocomial pneumonia in ventilated patients: a cohort study evaluating attributable mortality and hospital stay","volume":"94","author":"JY Fagon","year":"1993","journal-title":"Am J Med"},{"issue":"7","key":"ppat.1008311.ref003","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1111\/j.1440-1843.2010.01819.x","article-title":"Pseudomonas aeruginosa: Host defence in lung diseases","volume":"15","author":"BJ Williams","year":"2010","journal-title":"Respirology"},{"issue":"1","key":"ppat.1008311.ref004","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/2052-0492-2-10","article-title":"The molecular mechanism of acute lung injury caused by Pseudomonas aeruginosa: from bacterial pathogenesis to host response","volume":"2","author":"T Sawa","year":"2014","journal-title":"J intensive care"},{"issue":"12","key":"ppat.1008311.ref005","doi-asserted-by":"crossref","first-page":"6349","DOI":"10.1128\/AAC.01388-12","article-title":"Genetic markers of widespread extensively drug-resistant Pseudomonas aeruginosa high-risk clones","volume":"56","author":"G Cabot","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"issue":"8","key":"ppat.1008311.ref006","article-title":"Treatment Efficacy of MEDI3902 in Pseudomonas aeruginosa Bloodstream Infection and Acute Pneumonia Rabbit Models","volume":"63","author":"HN Le","year":"2019","journal-title":"Antimicrob Agents Chemother"},{"issue":"15","key":"ppat.1008311.ref007","doi-asserted-by":"crossref","first-page":"7449","DOI":"10.1128\/JVI.00385-15","article-title":"Phage Therapy: a Step Forward in the Treatment of Pseudomonas aeruginosa Infections","volume":"89","author":"DP Pires","year":"2015","journal-title":"J Virol"},{"issue":"4","key":"ppat.1008311.ref008","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1586\/14760584.2014.890053","article-title":"Vaccines for Pseudomonas aeruginosa: a long and winding road","volume":"13","author":"GP Priebe","year":"2014","journal-title":"Expert Rev Vaccines"},{"issue":"3","key":"ppat.1008311.ref009","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/2049-632X.12033","article-title":"Pseudomonas aeruginosa: new insights into pathogenesis and host defenses","volume":"67","author":"SL Gellatly","year":"2013","journal-title":"Pathog Dis"},{"issue":"4s","key":"ppat.1008311.ref010","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1038\/nm1213","article-title":"Mucosal immunity and vaccines","volume":"11","author":"J Holmgren","year":"2005","journal-title":"Nat Med"},{"key":"ppat.1008311.ref011","doi-asserted-by":"crossref","first-page":"15480","DOI":"10.1038\/ncomms15480","article-title":"Design of live attenuated bacterial vaccines based on D-glutamate auxotrophy","volume":"8","author":"MP Cabral","year":"2017","journal-title":"Nat Commun"},{"issue":"1","key":"ppat.1008311.ref012","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1309\/KJRPC7DD5TR9NTDM","article-title":"Mucoid Pseudomonas in cystic fibrosis","volume":"128","author":"B Pritt","year":"2007","journal-title":"Am J Clin Pathol"},{"issue":"7","key":"ppat.1008311.ref013","doi-asserted-by":"crossref","first-page":"3998","DOI":"10.1128\/IAI.68.7.3998-4004.2000","article-title":"Acquisition of expression of the Pseudomonas aeruginosa ExoU cytotoxin leads to increased bacterial virulence in a murine model of acute pneumonia and systemic spread","volume":"68","author":"M Allewelt","year":"2000","journal-title":"Infect Immun"},{"issue":"12","key":"ppat.1008311.ref014","first-page":"e29113","article-title":"The Pseudomonas aeruginosa Reference Strain PA14 Displays Increased Virulence Due to a Mutation in ladS. Cornelis P, editor","volume":"6","author":"H Mikkelsen","year":"2011"},{"issue":"5","key":"ppat.1008311.ref015","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.ijantimicag.2016.02.010","article-title":"Impact of multidrug resistance on the pathogenicity of Pseudomonas aeruginosa: in vitro and in vivo studies","volume":"47","author":"S G\u00f3mez-Zorrilla","year":"2016","journal-title":"Int J Antimicrob Agents"},{"issue":"19","key":"ppat.1008311.ref016","doi-asserted-by":"crossref","first-page":"8101","DOI":"10.1073\/pnas.0609213104","article-title":"Population structure of Pseudomonas aeruginosa","volume":"104","author":"L Wiehlmann","year":"2007","journal-title":"Proc Natl Acad Sci"},{"issue":"3","key":"ppat.1008311.ref017","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.cmi.2017.06.018","article-title":"Global emergence of the widespread Pseudomonas aeruginosa ST235 clone","volume":"24","author":"P Treepong","year":"2018","journal-title":"Clin Microbiol Infect"},{"issue":"11","key":"ppat.1008311.ref018","doi-asserted-by":"crossref","first-page":"5527","DOI":"10.1128\/AAC.01481-13","article-title":"Biological markers of Pseudomonas aeruginosa epidemic high-risk clones","volume":"57","author":"X Mulet","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"issue":"8","key":"ppat.1008311.ref019","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1128\/JCM.00753-11","article-title":"Wide dispersion of ST175 clone despite high genetic diversity of carbapenem-nonsusceptible Pseudomonas aeruginosa clinical strains in 16 Spanish hospitals","volume":"49","author":"M Garc\u00eda-Castillo","year":"2011","journal-title":"J Clin Microbiol"},{"issue":"7","key":"ppat.1008311.ref020","doi-asserted-by":"crossref","first-page":"4662","DOI":"10.4049\/jimmunol.177.7.4662","article-title":"IL-17 production is dominated by gammadelta T cells rather than CD4 T cells during Mycobacterium tuberculosis infection","volume":"177","author":"E Lockhart","year":"2006","journal-title":"J Immunol"},{"issue":"7","key":"ppat.1008311.ref021","doi-asserted-by":"crossref","first-page":"4965","DOI":"10.4049\/jimmunol.181.7.4965","article-title":"IL-17 is a critical component of vaccine-induced protection against lung infection by lipopolysaccharide-heterologous strains of Pseudomonas aeruginosa","volume":"181","author":"GP Priebe","year":"2008","journal-title":"J Immunol"},{"issue":"14\u201315","key":"ppat.1008311.ref022","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.micinf.2011.07.011","article-title":"Innate immune responses to Pseudomonas aeruginosa infection","volume":"13","author":"EG Lavoie","year":"2011","journal-title":"Microbes Infect"},{"issue":"1","key":"ppat.1008311.ref023","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/infdis\/jis657","article-title":"Collaboration between macrophages and vaccine-induced CD4+ T cells confers protection against lethal Pseudomonas aeruginosa pneumonia during neutropenia","volume":"207","author":"A Kamei","year":"2013","journal-title":"J Infect Dis"},{"issue":"1","key":"ppat.1008311.ref024","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S1074-7613(03)00174-2","article-title":"Blood monocytes consist of two principal subsets with distinct migratory properties","volume":"19","author":"F Geissmann","year":"2003","journal-title":"Immunity"},{"issue":"1","key":"ppat.1008311.ref025","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s13054-017-1601-9","article-title":"A randomized placebo-controlled phase II study of a Pseudomonas vaccine in ventilated ICU patients","volume":"21","author":"J Rello","year":"2017","journal-title":"Crit Care"},{"issue":"26","key":"ppat.1008311.ref026","doi-asserted-by":"crossref","first-page":"11020","DOI":"10.1073\/pnas.0702403104","article-title":"A double-blind randomized placebo-controlled phase III study of a Pseudomonas aeruginosa flagella vaccine in cystic fibrosis patients","volume":"104","author":"G D\u00f6ring","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"ppat.1008311.ref027","doi-asserted-by":"crossref","first-page":"5300","DOI":"10.1128\/IAI.00501-09","article-title":"Inescapable need for neutrophils as mediators of cellular innate immunity to acute Pseudomonas aeruginosa pneumonia","volume":"77","author":"AY Koh","year":"2009","journal-title":"Infect Immun"},{"issue":"3","key":"ppat.1008311.ref028","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s00441-017-2785-7","article-title":"Neutrophils in tissue injury and repair","volume":"371","author":"J Wang","year":"2018","journal-title":"Cell Tissue Res"},{"issue":"1","key":"ppat.1008311.ref029","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1086\/595011","article-title":"Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America","volume":"48","author":"HW Boucher","year":"2009","journal-title":"Clin Infect Dis"},{"issue":"1","key":"ppat.1008311.ref030","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/S1473-3099(10)70258-9","article-title":"Clinical outcomes of health-care-associated infections and antimicrobial resistance in patients admitted to European intensive-care units: a cohort study","volume":"11","author":"M-L Lambert","year":"2011","journal-title":"Lancet Infect Dis"},{"issue":"5","key":"ppat.1008311.ref031","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1093\/clinids\/23.5.973","article-title":"Evaluation of outcome for intubated patients with pneumonia due to Pseudomonas aeruginosa","volume":"23","author":"J Rello","year":"1996","journal-title":"Clin Infect Dis"},{"issue":"4","key":"ppat.1008311.ref032","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1378\/chest.109.4.1019","article-title":"Ventilator-associated pneumonia due to Pseudomonas aeruginosa","volume":"109","author":"S Crouch Brewer","year":"1996","journal-title":"ChestApr"},{"issue":"2","key":"ppat.1008311.ref033","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/nri1777","article-title":"Mucosal vaccines: the promise and the challenge","volume":"6","author":"MR Neutra","year":"2006","journal-title":"Nat Rev Immunol"},{"issue":"4","key":"ppat.1008311.ref034","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1086\/377000","article-title":"Genotypic and phenotypic analysis of type III secretion system in a cohort of Pseudomonas aeruginosa bacteremia isolates: evidence for a possible association between O serotypes and exo genes","volume":"188","author":"P Berthelot","year":"2003","journal-title":"J Infect Dis"},{"issue":"3","key":"ppat.1008311.ref035","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1046\/j.1365-2958.1997.4891851.x","article-title":"ExoU expression by Pseudomonas aeruginosa correlates with acute cytotoxicity and epithelial injury","volume":"25","author":"V Finck-Barban\u00e7on","year":"1997","journal-title":"Mol Microbiol"},{"issue":"5","key":"ppat.1008311.ref036","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1164\/rccm.201202-0182OC","article-title":"Th17-stimulating protein vaccines confer protection against Pseudomonas aeruginosa pneumonia","volume":"186","author":"W Wu","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"ppat.1008311.ref037","doi-asserted-by":"crossref","first-page":"18823","DOI":"10.1038\/srep18823","article-title":"X-ray Irradiated Vaccine Confers protection against Pneumonia caused by Pseudomonas Aeruginosa","volume":"6","author":"Y Li","year":"2016","journal-title":"Sci Rep"},{"issue":"2","key":"ppat.1008311.ref038","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/2049-632X.12043","article-title":"The responses of \u03b3\u03b4 T-cells against acute Pseudomonas aeruginosa pulmonary infection in mice via interleukin-17","volume":"68","author":"J Liu","year":"2013","journal-title":"Pathog Dis"},{"key":"ppat.1008311.ref039","first-page":"170","article-title":"IL17-Producing \u03b3\u03b4 T Cells May Enhance Humoral Immunity during Pulmonary Pseudomonas aeruginosa Infection in Mice","volume":"6","author":"T Pan","year":"2016","journal-title":"Front Cell Infect Microbiol"},{"issue":"4","key":"ppat.1008311.ref040","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/ni1449","article-title":"IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge","volume":"8","author":"SA Khader","year":"2007","journal-title":"Nat Immunol"},{"issue":"2","key":"ppat.1008311.ref041","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1574-695X.2010.00764.x","article-title":"Early production of IL-17 protects against acute pulmonary Pseudomonas aeruginosa infection in mice","volume":"61","author":"J Liu","year":"2011","journal-title":"FEMS Immunol Med Microbiol"},{"issue":"2","key":"ppat.1008311.ref042","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1165\/rcmb.2014-0395OC","article-title":"CD11b(+) Mononuclear Cells Mitigate Hyperoxia-Induced Lung Injury in Neonatal Mice","volume":"54","author":"LC Eldredge","year":"2016","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"Pt 4","key":"ppat.1008311.ref043","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1099\/mic.0.2006\/002261-0","article-title":"Defect in early lung defence against Pseudomonas aeruginosa in DBA\/2 mice is associated with acute inflammatory lung injury and reduced bactericidal activity in naive macrophages","volume":"153","author":"KR Wilson","year":"2007","journal-title":"Microbiology"},{"issue":"1","key":"ppat.1008311.ref044","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/mi.2016.28","article-title":"Vaccine-induced Th17 cells are established as resident memory cells in the lung and promote local","volume":"10","author":"D Christensen","year":"2017","journal-title":"IgA responses. Mucosal Immunol"},{"issue":"8","key":"ppat.1008311.ref045","doi-asserted-by":"crossref","first-page":"3535","DOI":"10.1172\/JCI97065","article-title":"Antibiotic treatment-induced secondary IgA deficiency enhances susceptibility to Pseudomonas aeruginosa pneumonia","volume":"128","author":"OH Robak","year":"2018","journal-title":"J Clin Invest"},{"key":"ppat.1008311.ref046","doi-asserted-by":"crossref","first-page":"14631","DOI":"10.1038\/ncomms14631","article-title":"Reconstruction of the metabolic network of Pseudomonas aeruginosa to interrogate virulence factor synthesis","volume":"8","author":"JA Bartell","year":"2017","journal-title":"Nat Commun"},{"issue":"2","key":"ppat.1008311.ref047","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1089\/104454904322759911","article-title":"Evaluation of Genetic Immunization Adjuvants to Improve the Effectiveness of a Human Immunodeficiency Virus Type 2 (HIV-2) Envelope DNA Vaccine","volume":"23","author":"CP Locher","year":"2004","journal-title":"DNA Cell Biol"},{"issue":"20","key":"ppat.1008311.ref048","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1016\/j.vaccine.2013.03.026","article-title":"Pneumococcal Surface Protein A does not affect the immune responses to a combined diphtheria tetanus and pertussis vaccine in mice","volume":"31","author":"FA Lima","year":"2013","journal-title":"Vaccine"},{"issue":"3","key":"ppat.1008311.ref049","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1128\/IAI.71.3.1453-1461.2003","article-title":"Protection against fatal Pseudomonas aeruginosa pneumonia in mice after nasal immunization with a live, attenuated aroA deletion mutant","volume":"71","author":"GP Priebe","year":"2003","journal-title":"Infect Immun"},{"issue":"7","key":"ppat.1008311.ref050","doi-asserted-by":"crossref","first-page":"0662","DOI":"10.1371\/journal.ppat.0020065","article-title":"Live attenuated B. pertussis as a single-dose nasal vaccine against whooping cough","volume":"2","author":"N Mielcarek","year":"2006","journal-title":"PLoS Pathog"},{"issue":"1","key":"ppat.1008311.ref051","doi-asserted-by":"crossref","first-page":"e83449","DOI":"10.1371\/journal.pone.0083449","article-title":"A phase I clinical study of a live attenuated Bordetella pertussis vaccine\u2014BPZE1; a single centre, double-blind, placebo-controlled, dose-escalating study of BPZE1 given intranasally to healthy adult male volunteers","volume":"9","author":"R Thorstensson","year":"2014","journal-title":"PLoS OneJan"},{"issue":"4","key":"ppat.1008311.ref052","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1093\/jac\/dkq030","article-title":"Risk factors and prognosis of post-operative pneumonia due to Pseudomonas aeruginosa following cardiac surgery","volume":"65","author":"N Allou","year":"2010","journal-title":"J Antimicrob Chemother"},{"issue":"3","key":"ppat.1008311.ref053","doi-asserted-by":"crossref","first-page":"e0193300","DOI":"10.1371\/journal.pone.0193300","article-title":"Risk factors for colonization and infection by Pseudomonas aeruginosa in patients hospitalized in intensive care units in France","volume":"13","author":"S Hoang","year":"2018","journal-title":"PLoS One"},{"issue":"1","key":"ppat.1008311.ref054","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/cncr.21115","article-title":"Risk factors for infections with multidrug-resistant Pseudomonas aeruginosa in patients with cancer","volume":"104","author":"N Ohmagari","year":"2005","journal-title":"Cancer"},{"issue":"6","key":"ppat.1008311.ref055","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1093\/clinids\/18.6.886","article-title":"Pseudomonas aeruginosa Bacteremia in Patients with AIDS","volume":"18","author":"MH Mendelson","year":"1994","journal-title":"Clin Infect Dis"},{"issue":"2","key":"ppat.1008311.ref056","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1128\/CVI.00419-07","article-title":"Vaccination against Pseudomonas aeruginosa pneumonia in immunocompromised mice","volume":"15","author":"JM Scarff","year":"2008","journal-title":"Clin Vaccine Immunol"},{"issue":"2","key":"ppat.1008311.ref057","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/imm.12191","article-title":"Protective effect of intranasal immunization with Neospora caninum membrane antigens against murine neosporosis established through the gastrointestinal tract","volume":"141","author":"P Ferreirinha","year":"2014","journal-title":"Immunology"},{"issue":"3","key":"ppat.1008311.ref058","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/0090-1229(82)90331-2","article-title":"The isolation and functional activity of polymorphonuclear leukocytes and lymphocytes separated from whole blood on a single Percoll density gradient","volume":"23","author":"RJ Harbeck","year":"1982","journal-title":"Clin Immunol Immunopathol"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1008311","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T00:00:00Z","timestamp":1582243200000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1008311","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T14:01:02Z","timestamp":1582293662000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1008311"}},"subtitle":[],"editor":[{"given":"David","family":"Skurnik","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2020,2,10]]},"references-count":58,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,2,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1008311","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.ppat.1008311","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,10]]}}}