{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T07:47:38Z","timestamp":1768981658915,"version":"3.49.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2004,5,1]],"date-time":"2004-05-01T00:00:00Z","timestamp":1083369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Background: B-Type natriuretic peptide (BNP) is released from the left ventricle of the heart into the circulation in response to ventricular stretching and volume overload. Increased BNP concentrations are associated with heart failure (HF).<\/jats:p>\n               <jats:p>Methods: We evaluated the analytical and clinical performance of the Bayer ADVIA Centaur\u00ae BNP assay. Studies included precision, analytical correlation (against the Shionogi ShionoRIA\u2122 and Biosite Triage\u00ae BNP assays), BNP results for blood collected in plastic tubes containing EDTA vs other collection tubes, high-dose hook effect, detection limits, and interferences. The clinical performance was tested on 2243 blood samples collected from 983 apparently healthy individuals, 538 patients with chronic disease but without HF (renal insufficiency, chronic obstructive pulmonary disease, diabetes, and hypertension), and 722 patients with HF (New York Heart Association classes I-IV).<\/jats:p>\n               <jats:p>Results: The ADVIA Centaur assay had total imprecision (CV) of 3.4%, 2.9%, and 2.4% at BNP concentrations of 48, 461, and 1768 ng\/L, respectively. The Passing\u2013Bablok correlations to the ShionoRIA and Triage were as follows: ADVIA Centaur = 1.11(ShionoRIA) \u2212 1.19 ng\/L (r = 0.98); ADVIA Centaur = 0.78(Triage) + 5.89 ng\/L (r = 0.92), respectively. Of the different blood collection tubes, only EDTA plastic tubes (with and without the barrier gel) were acceptable. The lower detection limit was 0.5 ng\/L, and there were no interferences from common analytes, other neuropeptides, or unusual antibodies. BNP exhibited different reference intervals according to age and gender. BNP concentrations increased progressively as the severity of HF increased.<\/jats:p>\n               <jats:p>Conclusions: The ADVIA Centaur is the first commercially available BNP assay for use on an automated immunochemistry platform. This assay has good analytical and clinical performance characteristics for diagnosing HF.<\/jats:p>","DOI":"10.1373\/clinchem.2003.026138","type":"journal-article","created":{"date-parts":[[2004,3,16]],"date-time":"2004-03-16T01:12:50Z","timestamp":1079399570000},"page":"867-873","source":"Crossref","is-referenced-by-count":112,"title":["Analytical and Clinical Evaluation of the Bayer ADVIA Centaur Automated B-Type Natriuretic Peptide Assay in Patients with Heart Failure: A Multisite Study"],"prefix":"10.1093","volume":"50","author":[{"given":"Alan H B","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Hartford Hospital, 80 Seymour St., Hartford, CT 06102"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milton","family":"Packer","sequence":"first","affiliation":[{"name":"Departments of Medicine and Pathology, Columbia Presbyterian Medical Center, New York, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Smith","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Hartford Hospital, 80 Seymour St., Hartford, CT 06102"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Bijou","sequence":"first","affiliation":[{"name":"Departments of Medicine and Pathology, Columbia Presbyterian Medical Center, New York, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Fink","sequence":"first","affiliation":[{"name":"Departments of Medicine and Pathology, Columbia Presbyterian Medical Center, New York, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Mair","sequence":"first","affiliation":[{"name":"Department of Internal Medicine\/Division of Cardiology, University of Innsbruck, Innsbruck, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Wallentin","sequence":"first","affiliation":[{"name":"Uppsala Clinical Research Center and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Johnston","sequence":"first","affiliation":[{"name":"Department of Cardiology, Cardiothoracic Center, Uppsala University Hospital, Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolyn S","family":"Feldcamp","sequence":"first","affiliation":[{"name":"Pathology Department, Henry Ford Hospital, Detroit, MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doris M","family":"Haverstick","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Virginia, Charlottesville, VA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charaf E","family":"Ahnadi","sequence":"first","affiliation":[{"name":"Centre for Research and Evaluation in Diagnostics, CRED, Sherbrooke, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Grant","sequence":"first","affiliation":[{"name":"Centre for Research and Evaluation in Diagnostics, CRED, Sherbrooke, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Normand","family":"Despres","sequence":"first","affiliation":[{"name":"Bayer Healthcare LLC, Diagnostics Division, Tarrytown, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry","family":"Bluestein","sequence":"first","affiliation":[{"name":"Bayer Healthcare LLC, Diagnostics Division, Tarrytown, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farooq","family":"Ghani","sequence":"first","affiliation":[{"name":"Bayer Healthcare LLC, Diagnostics Division, Tarrytown, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2004,5,1]]},"reference":[{"key":"2020030122460416800_R1","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1056\/NEJMoa020233","volume":"347","year":"2002","journal-title":"N Engl J Med"},{"key":"2020030122460416800_R2","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1046\/j.1445-5994.2001.00042.x","volume":"31","year":"2001","journal-title":"Intern Med J"},{"key":"2020030122460416800_R3","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1053\/euhj.2001.2783","volume":"22","year":"2001","journal-title":"Eur Heart J"},{"key":"2020030122460416800_R4","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0009-8981(02)00389-3","volume":"328","year":"2003","journal-title":"Clin Chim Acta"},{"key":"2020030122460416800_R5","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1067\/mhj.2002.125623","volume":"144","year":"2002","journal-title":"Am Heart J"},{"key":"2020030122460416800_R6","first-page":"2","volume":"13","year":"1993","journal-title":"Jpn J Nucl Med"},{"key":"2020030122460416800_R7","year":"1999","journal-title":"Evaluation of precision performance of clinical chemistry devices; approved guideline. NCCLS guideline EP5-A"},{"key":"2020030122460416800_R8","first-page":"428","volume":"92","year":"2003","journal-title":"Am J Cardiol"},{"key":"2020030122460416800_R9","doi-asserted-by":"crossref","first-page":"47","DOI":"10.7326\/0003-4819-125-1-199607010-00008","volume":"125","year":"1996","journal-title":"Ann Intern Med"},{"key":"2020030122460416800_R10","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1053\/sonc.2001.19727","volume":"28","year":"2001","journal-title":"Semin Oncol"},{"key":"2020030122460416800_R11","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.cccn.2003.10.026","volume":"340","year":"2004","journal-title":"Clin Chim Acta"},{"key":"2020030122460416800_R12","first-page":"107","volume":"338","year":"2003","journal-title":"Clin Chim Acta 2003"},{"key":"2020030122460416800_R13","first-page":"46","year":"2001","journal-title":"Biological variation: from principles to practice"},{"key":"2020030122460416800_R14","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0009-8981(01)00745-8","volume":"316","year":"2002","journal-title":"Clin Chim Acta"},{"key":"2020030122460416800_R15","first-page":"446","volume":"39","year":"2001","journal-title":"Clin Chem Lab Med"},{"key":"2020030122460416800_R16","first-page":"29","volume":"47","year":"2001","journal-title":"Clin Lab"},{"key":"2020030122460416800_R17","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1093\/clinchem\/47.3.591","volume":"47","year":"2001","journal-title":"Clin Chem"},{"key":"2020030122460416800_R18","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1067\/mhj.2001.113215","volume":"141","year":"2001","journal-title":"Am Heart J"},{"key":"2020030122460416800_R19","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/S0735-1097(02)02059-4","volume":"40","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"2020030122460416800_R20","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1161\/hy0102.100537","volume":"39","year":"2002","journal-title":"Hypertension"},{"key":"2020030122460416800_R21","year":"2002","journal-title":"Heart disease and stroke statistics\u20132004 update."},{"key":"2020030122460416800_R22","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1053\/ajkd.2003.50118","volume":"41","year":"2003","journal-title":"Am J Kid Dis"},{"key":"2020030122460416800_R23","first-page":"158A","volume":"41","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"2020030122460416800_R24","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1001\/jama.1994.03520030047027","volume":"272","year":"1994","journal-title":"JAMA"},{"key":"2020030122460416800_R25","year":"2002","journal-title":"Triage BNP package insert"},{"key":"2020030122460416800_R26","year":"2003","journal-title":"ADVIA Centaur BNP package insert"},{"key":"2020030122460416800_R27","year":"2002","journal-title":"ProBNP package insert"},{"key":"2020030122460416800_R28","first-page":"II-3","volume":"104","year":"2001","journal-title":"Circulation"}],"container-title":["Clinical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/clinchem\/article-pdf\/50\/5\/867\/32734859\/clinchem0867.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/clinchem\/article-pdf\/50\/5\/867\/32734859\/clinchem0867.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T03:47:50Z","timestamp":1583120870000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/clinchem\/article\/50\/5\/867\/5640072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5,1]]},"references-count":28,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2004,5,1]]},"published-print":{"date-parts":[[2004,5,1]]}},"URL":"https:\/\/doi.org\/10.1373\/clinchem.2003.026138","relation":{},"ISSN":["0009-9147","1530-8561"],"issn-type":[{"value":"0009-9147","type":"print"},{"value":"1530-8561","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2004,5,1]]},"published":{"date-parts":[[2004,5,1]]}}}