{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T23:45:55Z","timestamp":1791071155459,"version":"4.1.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2004,3,1]],"date-time":"2004-03-01T00:00:00Z","timestamp":1078099200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Background: Eph receptors and their ligands, the ephrins, represent a large class of cell\u2013cell communication molecules with well-defined developmental functions. Their role in healthy adult tissues and in human disease is still largely unknown, although diverse roles in carcinogenesis have been postulated.<\/jats:p><jats:p>Methods: We established a set of fluorescent PCR probes and primers for the definition of individual gene expression profiles of 12 different Eph receptors and 8 ephrins in 13 different healthy tissues. The mRNA expression profiles were studied in human lung, colorectal, kidney, liver, and brain cancers.<\/jats:p><jats:p>Results: The family of Eph receptors\/ephrins was widely expressed in adult tissues with organ-site-specific patterns: EphB6 was highest in the thymus, compatible with an involvement in T-cell maturation. Brain and testis shared a unique pattern with EphA6, EphA8, and EphB1 being the most prominent. EphA7 had a high abundance in the kidney vasculature. Ephrin-A3 was up-regulated 26-fold in lung cancer, and EphB2 was up-regulated 9-fold in hepatocellular carcinoma. EphA8 was down-regulated in colon cancer, and EphA1\/EphA8 was down-regulated in glioblastomas.<\/jats:p><jats:p>Conclusion: Eph\/Ephrin genes are widely expressed in all adult organs with certain organ-site-specific patterns. Because their function in adult tissues remains unknown, further analysis of their role in disease may disclose new insights beyond their well-defined meaning in development.<\/jats:p>","DOI":"10.1373\/clinchem.2003.026849","type":"journal-article","created":{"date-parts":[[2004,2,23]],"date-time":"2004-02-23T20:57:49Z","timestamp":1077569869000},"page":"490-499","source":"Crossref","is-referenced-by-count":278,"title":["Differential Gene Expression of Eph Receptors and Ephrins in Benign Human Tissues and Cancers"],"prefix":"10.1093","volume":"50","author":[{"given":"Christian","family":"Hafner","sequence":"first","affiliation":[{"name":"Department of Dermatology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd","family":"Schmitz","sequence":"first","affiliation":[{"name":"Institute for Clinical Chemistry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Meyer","sequence":"first","affiliation":[{"name":"Department of Dermatology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frauke","family":"Bataille","sequence":"first","affiliation":[{"name":"Institute of Pathology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Hau","sequence":"first","affiliation":[{"name":"Department of Neurology, University of Regensburg, Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Langmann","sequence":"first","affiliation":[{"name":"Institute for Clinical Chemistry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Dietmaier","sequence":"first","affiliation":[{"name":"Institute of Pathology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Landthaler","sequence":"first","affiliation":[{"name":"Department of Dermatology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Vogt","sequence":"first","affiliation":[{"name":"Department of Dermatology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2004,3,1]]},"reference":[{"key":"2020030122522079000_R1","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0092-8674(00)80500-0","volume":"90","year":"1997","journal-title":"Cell"},{"key":"2020030122522079000_R2","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0959-4388(98)80064-0","volume":"8","year":"1998","journal-title":"Curr Opin Neurobiol"},{"key":"2020030122522079000_R3","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/S0955-0674(97)80113-5","volume":"9","year":"1997","journal-title":"Curr Opin Cell Biol"},{"key":"2020030122522079000_R4","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S1359-6101(01)00031-4","volume":"13","year":"2002","journal-title":"Cytokine Growth Factor Rev"},{"key":"2020030122522079000_R5","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0092-8674(02)01015-2","volume":"111","year":"2002","journal-title":"Cell"},{"key":"2020030122522079000_R6","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1002\/(SICI)1097-0215(19991022)84:5<494::AID-IJC8>3.0.CO;2-O","volume":"84","year":"1999","journal-title":"Int J Cancer"},{"key":"2020030122522079000_R7","first-page":"791","volume":"4","year":"1998","journal-title":"Clin Cancer Res"},{"key":"2020030122522079000_R8","first-page":"3645","volume":"54","year":"1994","journal-title":"Cancer Res"},{"key":"2020030122522079000_R9","doi-asserted-by":"crossref","first-page":"10936","DOI":"10.1073\/pnas.190123297","volume":"97","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2020030122522079000_R10","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1002\/(SICI)1097-0045(19991201)41:4<275::AID-PROS8>3.0.CO;2-T","volume":"41","year":"1999","journal-title":"Prostate"},{"key":"2020030122522079000_R11","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1002\/ijc.10860","volume":"103","year":"2003","journal-title":"Int J Cancer"},{"key":"2020030122522079000_R12","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1242\/jcs.115.5.1059","volume":"115","year":"2002","journal-title":"J Cell Sci"},{"key":"2020030122522079000_R13","doi-asserted-by":"crossref","first-page":"5396","DOI":"10.1093\/emboj\/19.20.5396","volume":"19","year":"2000","journal-title":"EMBO J"},{"key":"2020030122522079000_R14","doi-asserted-by":"crossref","first-page":"7011","DOI":"10.1038\/sj.onc.1205679","volume":"21","year":"2002","journal-title":"Oncogene"},{"key":"2020030122522079000_R15","first-page":"2840","volume":"62","year":"2002","journal-title":"Cancer Res"},{"key":"2020030122522079000_R16","doi-asserted-by":"crossref","first-page":"46974","DOI":"10.1074\/jbc.M208495200","volume":"277","year":"2002","journal-title":"J Biol Chem"},{"key":"2020030122522079000_R17","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1038\/414933a","volume":"414","year":"2001","journal-title":"Nature"},{"key":"2020030122522079000_R18","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1373\/49.2.230","volume":"49","year":"2003","journal-title":"Clin Chem"},{"key":"2020030122522079000_R19","first-page":"452","volume":"6","year":"2000","journal-title":"Clin Cancer Res"},{"key":"2020030122522079000_R20","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1126\/science.1075762","volume":"298","year":"2002","journal-title":"Science"},{"key":"2020030122522079000_R21","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S1567-133X(02)00054-6","volume":"2","year":"2002","journal-title":"Gene Expr Patterns"},{"key":"2020030122522079000_R22","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0006-291X(02)02399-9","volume":"298","year":"2002","journal-title":"Biochem Biophys Res Commun"},{"key":"2020030122522079000_R23","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1172\/JCI0215883","volume":"110","year":"2002","journal-title":"J Clin Invest"},{"key":"2020030122522079000_R24","doi-asserted-by":"crossref","first-page":"5159","DOI":"10.1093\/emboj\/18.19.5159","volume":"18","year":"1999","journal-title":"EMBO J"},{"key":"2020030122522079000_R25","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1182\/blood.V100.4.1326.h81602001326_1326_1333","volume":"100","year":"2002","journal-title":"Blood"},{"key":"2020030122522079000_R26","doi-asserted-by":"crossref","first-page":"3073","DOI":"10.1242\/jcs.115.15.3073","volume":"115","year":"2002","journal-title":"J Cell Sci"},{"key":"2020030122522079000_R27","doi-asserted-by":"crossref","first-page":"9219","DOI":"10.1073\/pnas.142053899","volume":"99","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2020030122522079000_R28","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/jemt.10177","volume":"59","year":"2002","journal-title":"Microsc Res Tech"},{"key":"2020030122522079000_R29","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1677\/jme.0.0290023","volume":"29","year":"2002","journal-title":"J Mol Endocrinol"},{"key":"2020030122522079000_R30","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.4049\/jimmunol.167.3.1362","volume":"167","year":"2001","journal-title":"J Immunol"},{"key":"2020030122522079000_R31","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0959-437X(02)00316-7","volume":"12","year":"2002","journal-title":"Curr Opin Genet Dev"},{"key":"2020030122522079000_R32","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/path.893","volume":"195","year":"2001","journal-title":"J Pathol"},{"key":"2020030122522079000_R33","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1002\/cncr.10122","volume":"94","year":"2002","journal-title":"Cancer"},{"key":"2020030122522079000_R34","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0006-8993(99)01112-9","volume":"821","year":"1999","journal-title":"Brain Res"},{"key":"2020030122522079000_R35","first-page":"3425","volume":"63","year":"2003","journal-title":"Cancer Res"},{"key":"2020030122522079000_R36","first-page":"985","volume":"9","year":"2002","journal-title":"Oncol Rep"},{"key":"2020030122522079000_R37","first-page":"1553","volume":"23","year":"2003","journal-title":"Int J Oncol"},{"key":"2020030122522079000_R38","first-page":"S3","volume":"38","year":"2002","journal-title":"Eur J Cancer"},{"key":"2020030122522079000_R39","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1476-4598-1-2","volume":"1","year":"2002","journal-title":"Mol Cancer Res"},{"key":"2020030122522079000_R40","first-page":"4855","volume":"60","year":"2000","journal-title":"Cancer Res"}],"container-title":["Clinical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/clinchem\/article-pdf\/50\/3\/490\/32735328\/clinchem0490.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/clinchem\/article-pdf\/50\/3\/490\/32735328\/clinchem0490.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T21:19:17Z","timestamp":1623705557000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/clinchem\/article\/50\/3\/490\/5639809"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,3,1]]},"references-count":40,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2004,3,1]]},"published-print":{"date-parts":[[2004,3,1]]}},"URL":"https:\/\/doi.org\/10.1373\/clinchem.2003.026849","relation":{},"ISSN":["0009-9147","1530-8561"],"issn-type":[{"value":"0009-9147","type":"print"},{"value":"1530-8561","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2004,3,1]]},"published":{"date-parts":[[2004,3,1]]}}}