{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T23:35:02Z","timestamp":1772580902025,"version":"3.50.1"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T00:00:00Z","timestamp":1093996800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Background: The ratio of plasma aldosterone concentration to plasma renin activity (PAC\/PRA) is the most common screening test for primary hyperaldosteronism (PHA), but it is not standardized among laboratories. We evaluated new automated assays for the simultaneous measurement of PAC and plasma renin concentration (PRC).<\/jats:p>\n               <jats:p>Methods: We studied 76 healthy normotensive volunteers and 28 patients with confirmed PHA. PAC and PRC were measured immunochemically in EDTA plasma on the Nichols Advantage\u00ae chemiluminescence analyzer, and PRA was determined by an activity assay.<\/jats:p>\n               <jats:p>Results: In volunteers, PAC varied from 33.3 to 1930 pmol\/L, PRA from 1.13 to 19.7 ng \u00b7 mL\u22121 \u00b7 h\u22121 (0.215 ng \u00b7 mL\u22121 \u00b7 h\u22121 = 1 pmol \u00b7 L\u22121 \u00b7 s\u22121), and PRC from 5.70 to 116 mU\/L. PAC\/PRA ratios ranged from 4.35 to 494 (pmol\/L)\/(ng \u00b7 mL\u22121 \u00b7 h\u22121) and PAC\/PRC ratios from 0.69 to 71.0 pmol\/mU. In PHA patients, PAC ranged from 158 to 5012 pmol\/L, PRA from 0.40 to 1.70 ng \u00b7 mL\u22121 \u00b7 h\u22121, and PRC from 0.80 to 11.7 mU\/L. PAC\/PRA ratios were between 298 and 6756 (pmol\/L)\/(ng \u00b7 mL\u22121 \u00b7 h\u22121) and PAC\/PRC ratios between 105 and 2328 pmol\/mU. Whereas PAC or PRC showed broad overlap between PHA patients and volunteers, the PAC\/PRC ratio indicated distinct discrimination of these two groups at a cutoff of 71 pmol\/mU.<\/jats:p>\n               <jats:p>Conclusion: The PAC\/PRC ratio offers several practical advantages compared with the PAC\/PRA screening method. The present study offers preliminary evidence that it may be a useful screening test for PHA. Further studies are required to validate these results, especially in hypertensive cohorts.<\/jats:p>","DOI":"10.1373\/clinchem.2004.033159","type":"journal-article","created":{"date-parts":[[2004,7,10]],"date-time":"2004-07-10T01:06:37Z","timestamp":1089421597000},"page":"1650-1655","source":"Crossref","is-referenced-by-count":90,"title":["Rapid Screening Test for Primary Hyperaldosteronism: Ratio of Plasma Aldosterone to Renin Concentration Determined by Fully Automated Chemiluminescence Immunoassays"],"prefix":"10.1093","volume":"50","author":[{"given":"Frank Holger","family":"Perschel","sequence":"first","affiliation":[{"name":"Clinical Chemistry and Pathobiochemistry and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudolf","family":"Schemer","sequence":"first","affiliation":[{"name":"Nichols Institute Diagnostics, Bad Vilbel, 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