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Coronary artery calcification (CAC), a component of coronary artery atherosclerosis, was detectable in 10% of the cohort and appeared to be in its initial stages (Agatston scores &amp;lt;20 in 47% and &amp;lt;100 in 83% of CAC-positive participants). After adjusting for sex, clinical site, age, and race, the presence of any CAC was 24% more likely among those with high vs low concentrations of F2-isoprostanes [odds ratio (OR) = 1.24 per 92.2 pmol\/L (32.7 ng\/L; 1 SD of F2-isoprostanes); 95% confidence interval (CI), 1.09\u20131.41]. The OR was only slightly attenuated [1.18 per 92.2 pmol\/L (32.7 ng\/L); CI, 1.02\u20131.38] after further adjustment for body mass index, smoking, serum lipids, C-reactive protein, antioxidant supplementation use, diabetes, and blood pressure. As a continuous variable, the Agatston score increased by 6.9% per 92.2 pmol\/L (32.7 ng\/L) of F2-isoprostane concentration (P &amp;lt;0.01). Whereas CAC prevalence was lower in women than men, mean (SD), F2-isoprostanes were higher in women {190 (108.9) pmol\/L [67.4 (38.6) ng\/L]} than in men {140.4 (55.6) pmol\/L [49.8 (19.7) ng\/L]}. Nevertheless, F2-isoprostanes were associated with an increased risk of CAC in both sexes.<\/jats:p><jats:p>Conclusion: This association between increased concentrations of circulating F2-isoprostanes and CAC in young healthy adults supports the hypothesis that oxidative damage is involved in the early development of atherosclerosis.<\/jats:p>","DOI":"10.1373\/clinchem.2004.037630","type":"journal-article","created":{"date-parts":[[2004,10,29]],"date-time":"2004-10-29T00:25:54Z","timestamp":1099009554000},"page":"125-131","source":"Crossref","is-referenced-by-count":117,"title":["Plasma F2-Isoprostanes and Coronary Artery Calcification: The CARDIA Study"],"prefix":"10.1093","volume":"51","author":[{"given":"Myron","family":"Gross","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, School of Medicine, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Steffes","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, School of Medicine, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"David R","family":"Jacobs","sequence":"first","affiliation":[{"name":"Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN"},{"name":"The Department of Nutrition, University of Oslo, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinhua","family":"Yu","sequence":"first","affiliation":[{"name":"Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Lewis","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, School of Medicine, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cora E","family":"Lewis","sequence":"first","affiliation":[{"name":"Division of Preventive Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine M","family":"Loria","sequence":"first","affiliation":[{"name":"National Heart, Lung, and Blood Institute, Division of Epidemiology and Clinical Applications, Bethesda, MD"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2005,1,1]]},"reference":[{"key":"2020022800540158500_R1","doi-asserted-by":"crossref","unstructured":"Steinberg D, Parthasarathy S, Carew TE, Khoo JC, Witztum JL. 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