{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T23:29:38Z","timestamp":1776468578853,"version":"3.51.2"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Background: S-100B protein is an established serum marker of primary and secondary brain damage in head injury and stroke. Despite major progress in neurophysiologic monitoring, there are still difficulties in the early identification and quantification of evolving edema or trauma after craniotomy for tumor. In this study we aimed to correlate serum S-100B values with early postoperative neurologic course as well as late outcome in meningioma surgery.<\/jats:p><jats:p>Methods: We enrolled 50 consecutive patients who underwent meningioma resection. Serum S-100B was measured preoperatively and postcraniotomy for 7 consecutive days. Twenty-five patients (50%) developed immediate postoperative neurologic deterioration, and 15 (30%) had unfavorable 6-month outcomes. We used the Mann\u2013Whitney U-test to assess the association of S-100B with all variables of interest. We used multiple logistic regression to search for the most significant predictor of postoperative deterioration.<\/jats:p><jats:p>Results: Increased S-100B was highly correlated with larger tumors, intraoperative difficulties, postcraniotomy acute deterioration, and long-term poor outcome. In addition, multiple logistic regression showed that age, sex, site, preoperative edema, history of meningioma resection, extent of resection, and histologic type did not correlate with postoperative increases in S-100B. Furthermore, patients with postoperative S-100B values &amp;gt;0.4 \u03bcg\/L had increased risk of deterioration (relative risk = 9.0; 95% confidence interval, 2.4\u201334; P &amp;lt;0.0001) and of poor ultimate outcome (relative risk = 11; 95% confidence interval, 1.6\u201377; P = 0.002).<\/jats:p><jats:p>Conclusions: After meningioma excision, postcraniotomy increases in serum S-100B appear to be an early indicator of short-term postoperative neurologic deterioration and of a poor longer-term outcome.<\/jats:p>","DOI":"10.1373\/clinchem.2004.039719","type":"journal-article","created":{"date-parts":[[2004,11,19]],"date-time":"2004-11-19T01:13:50Z","timestamp":1100826830000},"page":"202-207","source":"Crossref","is-referenced-by-count":15,"title":["Serum S-100B as an Indicator of Early Postoperative Deterioration after Meningioma Surgery"],"prefix":"10.1093","volume":"51","author":[{"given":"George","family":"Stranjalis","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery, University of Athens,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefanos","family":"Korfias","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery, University of Athens,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Psachoulia","sequence":"first","affiliation":[{"name":"Biochemistry, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Efstathios","family":"Boviatsis","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery, University of Athens,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Kouyialis","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery, University of Athens,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Despina","family":"Protopappa","sequence":"first","affiliation":[{"name":"Pathology, Evangelismos Hospital, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damianos E","family":"Sakas","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery, University of Athens,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2005,1,1]]},"reference":[{"key":"2020022800541654700_R1","doi-asserted-by":"crossref","unstructured":"Bitzer M, Nagele T, Geist-Brath B, Klose U, Gronewaller E, Morgalla M, et al. Role of hydrodynamic processes in the pathogenesis of peritumoral edema in meningiomas. J Neurosurg2000;93:594-604.","DOI":"10.3171\/jns.2000.93.4.0594"},{"key":"2020022800541654700_R2","doi-asserted-by":"crossref","unstructured":"De Vries J, Wakhloo AK. Cerebral oedema associated with WHO I-II-III meningiomas. Acta Neurochir1993;125:34-40.","DOI":"10.1007\/BF01401825"},{"key":"2020022800541654700_R3","doi-asserted-by":"crossref","unstructured":"Mantle R, Lach B, Delgado MR, Baeesa S, Belanger G. Predicting the probability of meningioma recurrence based on the quantity of peritumoral brain edema on CT scan. J Neurosurg1994;91:375-383.","DOI":"10.3171\/jns.1999.91.3.0375"},{"key":"2020022800541654700_R4","doi-asserted-by":"crossref","unstructured":"Salpietro F, Alafaci C, Lucerna S, Iacopino DG, Todaro C, Tomasello F. Peritumoral edema in meningiomas. Neurosurgery1994;35:638-642.","DOI":"10.1227\/00006123-199410000-00009"},{"key":"2020022800541654700_R5","doi-asserted-by":"crossref","unstructured":"Tamiya T, Ono Y, Matsumoto K, Ohmoto T. Peritumoral brain edema in intracranial meningiomas: effects of radiological and histological factors. Neurosurgery2001;49:1046-1052.","DOI":"10.1097\/00006123-200111000-00003"},{"key":"2020022800541654700_R6","doi-asserted-by":"crossref","unstructured":"De Kruijk JR, Leffers P, Menheere PP, Meerhoff S, Rutten J, Twijnstra A. Prediction of post-traumatic complaints after mild traumatic brain injury: early symptoms and biochemical markers. J Neurol Neurosurg Psychiatry2002;73:727-732.","DOI":"10.1136\/jnnp.73.6.727"},{"key":"2020022800541654700_R7","doi-asserted-by":"crossref","unstructured":"Ingebrigtsen T, Romner B, Kongstad P, Langbakk B. Increased serum concentrations of protein S-100 after minor head injury: a biochemical serum marker with prognostic value?. J Neurol Neurosurg Psychiatry1995;59:103-104.","DOI":"10.1136\/jnnp.59.1.103-a"},{"key":"2020022800541654700_R8","doi-asserted-by":"crossref","unstructured":"Ingebrigtsen T, Waterloo K, Jacobsen EA, Langbakk B, Romner B. Traumatic brain damage in minor head injury: relation of serum S-100 protein measurements to MRI and neurobehavioral outcome. Neurosurgery1999;45:468-476.","DOI":"10.1097\/00006123-199909000-00010"},{"key":"2020022800541654700_R9","doi-asserted-by":"crossref","unstructured":"Raabe A, Grolms S, Sorge O, Zimmermann M, Seifert V. Serum S-100B in severe head injury. Neurosurgery1999;45:477-483.","DOI":"10.1097\/00006123-199909000-00012"},{"key":"2020022800541654700_R10","doi-asserted-by":"crossref","unstructured":"Rothoerl RD, Woertgen C, Holzschuh M, Metz C, Brawanski A. S-100 serum levels after minor and major head injury. J Trauma1998;45:765-767.","DOI":"10.1097\/00005373-199810000-00025"},{"key":"2020022800541654700_R11","doi-asserted-by":"crossref","unstructured":"Savola O, Hillbom M. Early predictors of post-concussion symptoms in patients with mild head injury. Eur J Neurol2003;10:175-181.","DOI":"10.1046\/j.1468-1331.2003.00552.x"},{"key":"2020022800541654700_R12","doi-asserted-by":"crossref","unstructured":"Woertgen C. Comparison of serial S-100B and NSE serum measurement after severe head injury. J Trauma1999;6:1126-1130.","DOI":"10.1097\/00005373-199912000-00026"},{"key":"2020022800541654700_R13","unstructured":"Trittmacher S. Observations on preoperative and postoperative changes in brain tissue surrounding meningiomas. Schmiedek HH eds. Meningiomas and their surgical management1991:63-69 WB Saunders Philadelphia. ."},{"key":"2020022800541654700_R14","unstructured":"Kleihues P, Burger PC, Scheithauer BW. Histological typing of tumors of CNS, 2nd ed1993:28-31 Springer Verlag Berlin. ."},{"key":"2020022800541654700_R15","doi-asserted-by":"crossref","unstructured":"Jennett B, Bond M. Assessment of outcome after severe brain damage. A practical scale. Lancet1975;I:480-484.","DOI":"10.1016\/S0140-6736(75)92830-5"},{"key":"2020022800541654700_R16","unstructured":"Conover WJ. Practical nonparametric statistics, 2nd ed1980:584pp John Wiley & Sons Inc. New York. ."},{"key":"2020022800541654700_R17","unstructured":"Atkinson K. Elementary numerical analysis, 2nd ed1993:448pp John Wiley & Sons Inc. New York. ."},{"key":"2020022800541654700_R18","doi-asserted-by":"crossref","unstructured":"Albert A, Anderson JA. On the existence of maximum likelihood estimates in logistic regression models. Biometrika1984;71:1-10.","DOI":"10.1093\/biomet\/71.1.1"},{"key":"2020022800541654700_R19","doi-asserted-by":"crossref","unstructured":"Hanley JA, McNeil BJ. The meaning and use of the area under a receiver operating characteristic (ROC) curve. Radiology1982;143:29-36.","DOI":"10.1148\/radiology.143.1.7063747"},{"key":"2020022800541654700_R20","doi-asserted-by":"crossref","unstructured":"Jackson RG, Samra GS, Radcliffe J, Clark GH, Price CP. The early fall in levels of S-100 \u03b2 in traumatic brain injury. Clin Chem Lab Med2000;38:1165-1167.","DOI":"10.1515\/CCLM.2000.179"},{"key":"2020022800541654700_R21","doi-asserted-by":"crossref","unstructured":"Tatagiba M, Mirzai S, Samii M. Peritumoral blood flow in intracranial meningiomas. Neurosurgery1991;28:400-404.","DOI":"10.1227\/00006123-199103000-00010"},{"key":"2020022800541654700_R22","doi-asserted-by":"crossref","unstructured":"De Vries J. Perioperative levels of S-100 protein in serum: marker for surgical manipulation and postoperative complications. Minim Invasive Neurosurg2003;46:33-36.","DOI":"10.1055\/s-2003-37963"}],"container-title":["Clinical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/clinchem\/article-pdf\/51\/1\/202\/32682302\/clinchem0202.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/clinchem\/article-pdf\/51\/1\/202\/32682302\/clinchem0202.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,30]],"date-time":"2023-04-30T09:56:33Z","timestamp":1682848593000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/clinchem\/article\/51\/1\/202\/5629575"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1,1]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2005,1,1]]},"published-print":{"date-parts":[[2005,1,1]]}},"URL":"https:\/\/doi.org\/10.1373\/clinchem.2004.039719","relation":{},"ISSN":["0009-9147","1530-8561"],"issn-type":[{"value":"0009-9147","type":"print"},{"value":"1530-8561","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2005,1,1]]},"published":{"date-parts":[[2005,1,1]]}}}