{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:52:54Z","timestamp":1791381174357,"version":"4.3.3"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T00:00:00Z","timestamp":1117584000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Background: Oxidative stress and neuronal cell death have been implicated in the pathogenesis of Alzheimer disease (AD). Considering that the glutathione transferase (GST) supergene family encodes isoenzymes that appear to be critical in protection against oxidative stress, we aimed at determining the various GSTP1, GSTM1, and GSTT1 polymorphisms and ApoE genotypes to investigate their role as susceptibility genes for late-onset AD (LOAD).<\/jats:p>\n               <jats:p>Methods: We included 210 LOAD patients and 228 healthy controls matched for age, sex, and educational level in our case\u2013control genetic association study. GSTM1 and GSTT1 genotypes were studied by conventional PCR, whereas GSTP1 and ApoE genotypes were determined by real-time PCR on the LightCycler.<\/jats:p>\n               <jats:p>Results: We found a significant association between LOAD and the GSTP1*C allelic variant [odds ratio (OR) = 1.9; P &amp;lt;0.05], but no association between the GSTM1 and GSTT1 deleted genotypes and LOAD. In addition, a preliminary result suggested that carriers of both the GSTP1*C and ApoE \u03b54 allelic variants were at increased risk of LOAD (OR = 19.98; P &amp;lt;0.0001).<\/jats:p>\n               <jats:p>Conclusion: The GSTP1*C allelic variant should be considered a candidate for LOAD, particularly in persons having the ApoE \u03b54 allelic variant, because the GSTP1 and ApoE gene products are implicated in oxidative stress and apoptosis processes leading to \u03b2-amyloid-mediated neurodegeneration.<\/jats:p>","DOI":"10.1373\/clinchem.2004.045955","type":"journal-article","created":{"date-parts":[[2005,4,2]],"date-time":"2005-04-02T01:14:09Z","timestamp":1112404449000},"page":"944-951","source":"Crossref","is-referenced-by-count":42,"title":["Glutathione S-Transferase P1 *C Allelic Variant Increases Susceptibility for Late-Onset Alzheimer Disease: Association Study and Relationship with Apolipoprotein E \u03b54 Allele"],"prefix":"10.1093","volume":"51","author":[{"given":"Sergio","family":"Bernardini","sequence":"first","affiliation":[{"name":"Departments of Internal Medicine and Laboratory Medicine-PTV, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenza","family":"Bellincampi","sequence":"first","affiliation":[{"name":"Departments of Internal Medicine and Laboratory Medicine-PTV, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Ballerini","sequence":"first","affiliation":[{"name":"Departments of Internal Medicine and Laboratory Medicine-PTV, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Federici","sequence":"first","affiliation":[{"name":"Departments of Internal Medicine and Laboratory Medicine-PTV, and"},{"name":"Bambino Gesu\u0300-Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Hospital, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Iori","sequence":"first","affiliation":[{"name":"Departments of Internal Medicine and Laboratory Medicine-PTV, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Trequattrini","sequence":"first","affiliation":[{"name":"ASL Citta\u0300 di Castello, Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Ciappi","sequence":"first","affiliation":[{"name":"ASL Citta\u0300 di Castello, Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Baldinetti","sequence":"first","affiliation":[{"name":"Istituto di Ricovero e Cura a Carattere Scientifico Fondazione Santa Lucia, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Bossu\u0300","sequence":"first","affiliation":[{"name":"Istituto di Ricovero e Cura a Carattere Scientifico Fondazione Santa Lucia, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Caltagirone","sequence":"first","affiliation":[{"name":"Istituto di Ricovero e Cura a Carattere Scientifico Fondazione Santa Lucia, Rome, Italy"},{"name":"Department of Neuroscience, University of Rome \u201cTor Vergata\u201d, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Spalletta","sequence":"first","affiliation":[{"name":"Istituto di Ricovero e Cura a Carattere Scientifico Fondazione Santa Lucia, Rome, Italy"},{"name":"Department of Neuroscience, University of Rome \u201cTor Vergata\u201d, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,6,1]]},"reference":[{"key":"2020022800550756200_R1","doi-asserted-by":"crossref","unstructured":"Khachaturian AS, Corcoran CD, Mayer LS, Zandi PP, Breitner JC. 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