{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:35:27Z","timestamp":1787164527796,"version":"build-2736575974"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2005,8,1]],"date-time":"2005-08-01T00:00:00Z","timestamp":1122854400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background: Heart-type fatty acid\u2013binding protein (H-FABP) is proposed as an early biomarker for acute myocardial infarction (AMI), but its prognostic value is unclear in acute coronary syndrome (ACS). We evaluated the prognostic value of the H-FABP concentration relative to cardiac troponin T (cTnT) in the early hours of ACS.<\/jats:p>\n                  <jats:p>Methods: Serum concentrations of H-FABP and cTnT were measured on admission in 328 consecutive patients hospitalized for ACS within 6 h after the onset of chest pain [AMI, 241 (73.5%) patients; ST-segment elevation myocardial infarction, 154 (47.0%) patients; and emergent coronary angiography within 24 h after admission, 287 (87.5%) patients]. Cardiac events, which were defined as cardiac death or subsequent nonfatal AMI, were monitored for 6 months after admission.<\/jats:p>\n                  <jats:p>Results: During the 6-month follow-up period, there were 25 cardiac events, including 15 cardiac deaths and 10 subsequent nonfatal AMIs. Stepwise multivariate analyses including clinical, electrocardiographic, and biochemical variables revealed that increased H-FABP (above the median of 9.8 \u03bcg\/L), but not increased cTnT (above the median of 0.02 \u03bcg\/L), was independently associated with cardiac events in all patients [relative risk (RR) = 8.96; P = 0.0004], the subgroup of patients with ST-segment elevation myocardial infarction (RR = 11.3; P = 0.02), and the subgroup of patients with unstable angina and non-ST-segment elevation myocardial infarction (RR = 8.31; P = 0.007). The area under the ROC curve was higher for H-FABP than for cTnT (0.711 vs 0.578; P = 0.08), suggesting that H-FABP concentrations have a greater predictive capacity for cardiac events than cTnT.<\/jats:p>\n                  <jats:p>Conclusion: Serum H-FABP is a potential independent predictor of cardiac events within 6 months of patient admission and may provide prognostic information superior to cTnT in the early hours of ACS.<\/jats:p>","DOI":"10.1373\/clinchem.2004.047662","type":"journal-article","created":{"date-parts":[[2005,6,10]],"date-time":"2005-06-10T20:13:54Z","timestamp":1118434434000},"page":"1397-1404","source":"Crossref","is-referenced-by-count":62,"title":["Prognostic Value of Serum Concentration of Heart-Type Fatty Acid\u2013Binding Protein Relative to Cardiac Troponin T on Admission in the Early Hours of Acute Coronary Syndrome"],"prefix":"10.1093","volume":"51","author":[{"given":"Junnichi","family":"Ishii","sequence":"first","affiliation":[{"name":"Division of Critical Care, Fujita Health University Graduate School of Health Sciences, Toyoake, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Ozaki","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Fujita Health University School of Medicine, Toyoake, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingchao","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Fujita Health University School of Medicine, Toyoake, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumihiko","family":"Kitagawa","sequence":"first","affiliation":[{"name":"Department of Joint Research Laboratory of Clinical Medicine, Fujita Health University Hospital, Toyoake, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Kuno","sequence":"first","affiliation":[{"name":"Department of Joint Research Laboratory of Clinical Medicine, Fujita Health University Hospital, Toyoake, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Nakano","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Fujita Health University School of Medicine, Toyoake, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuu","family":"Nakamura","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Fujita Health University School of Medicine, Toyoake, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Naruse","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Fujita Health University School of Medicine, Toyoake, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihisa","family":"Mori","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Fujita Health University School of Medicine, Toyoake, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Matsui","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Fujita Health University School of Medicine, Toyoake, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisaji","family":"Oshima","sequence":"first","affiliation":[{"name":"Department of Joint Research Laboratory of Clinical Medicine, Fujita Health University Hospital, Toyoake, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Nomura","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Fujita Health University School of Medicine, Toyoake, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouji","family":"Ezaki","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Fujita Health University School of Medicine, Toyoake, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Hishida","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Fujita Health University School of Medicine, Toyoake, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,8,1]]},"reference":[{"key":"2020022800542870300_R1","doi-asserted-by":"crossref","unstructured":"Lin L, Sylve\u0301n C, Sotonyi P, Somogyi E, Kaijser L, Jansson E. 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