{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:18:22Z","timestamp":1760188702727},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Background: Third-generation parathyroid hormone (PTH) assays have been reported to measure only intact PTH(1\u201384), in contrast to second-generation assays, which also detect PTH(7\u201384) fragments. Higher PTH measurements were observed with third- than with second-generation PTH assays in a few patients with either severe primary hyperparathyroidism or parathyroid carcinoma.<\/jats:p>\n               <jats:p>Methods: We analyzed biological data [second- and third-generation PTH assays, 25-hydroxyvitamin D (25-OHD), calcium, and phosphate concentrations] obtained before and after surgery for 2 groups of patients selected from a large series of consecutive patients with primary hyperparathyroidism (PHPT): 7 female patients with surgically and histologically confirmed PHPT (group 1) and a matched group (group 2).<\/jats:p>\n               <jats:p>Results: For group 1 but not group 2, PTH concentrations measured by third-generation PTH assays before surgery were higher than those measured by the second-generation assays. Circulating 25-OHD, calcium, and phosphate concentrations were similar in both groups. In addition, PTH values measured with the third-generation PTH assays in group 1 decreased after surgery.<\/jats:p>\n               <jats:p>Conclusions: Our results confirm that third-generation PTH assays do not measure only PTH(1\u201384). The frequency of this unexpected finding of markedly lower PTH concentrations than previously reported was \u223c5% in patients with PHPT without malignancy. We do not know whether the presence of this unexpected profile is predictive of malignancy.<\/jats:p>","DOI":"10.1373\/clinchem.2005.060962","type":"journal-article","created":{"date-parts":[[2006,2,23]],"date-time":"2006-02-23T20:59:09Z","timestamp":1140728349000},"page":"757-760","source":"Crossref","is-referenced-by-count":16,"title":["Unexpected Serum Parathyroid Hormone Profiles in Some Patients with Primary Hyperparathyroidism"],"prefix":"10.1093","volume":"52","author":[{"given":"Philippe","family":"Boudou","sequence":"first","affiliation":[{"name":"(Departments of Hormonal Biology and Endocrine Surgery,"},{"name":"(Departments of Hormonal Biology and Endocrine Surgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fidaa","family":"Ibrahim","sequence":"first","affiliation":[{"name":"(Departments of Hormonal Biology and Endocrine Surgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Cormier","sequence":"first","affiliation":[{"name":"Department of Rhumatologie, Ho\u0302pital Cochin, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emile","family":"Sarfati","sequence":"first","affiliation":[{"name":"Ho\u0302pital Saint-Louis, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Claude","family":"Souberbielle","sequence":"first","affiliation":[{"name":"Physiology Laboratory, Ho\u0302pital Necker-Enfants Malades, Assistance Publique, Ho\u0302pitaux de Paris, Paris, France; INSERM U 671, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2006,4,1]]},"reference":[{"key":"2020022801311882800_R1","doi-asserted-by":"crossref","unstructured":"Lepage R, Roy L, Brossard JH, Rousseau L, Dorais C, Lazure C, et al. A non-(1\u201384) circulating parathyroid hormone (PTH) fragment interferes significantly with intact PTH commercial assay measurements in uremic samples. Clin Chem1998;44:805-809.","DOI":"10.1093\/clinchem\/44.4.805"},{"key":"2020022801311882800_R2","doi-asserted-by":"crossref","unstructured":"Gao P, Scheibel S, D\u2019Amour P, John M, Rao S, Schmdt-Gayk H, et al. Development of a novel immunoradiometric assay exclusively for biologically active whole parathyroid hormone 1\u201384: implications for improvement of accurate assessment of parathyroid function. J Bone Miner Res2001;16:605-614.","DOI":"10.1359\/jbmr.2001.16.4.605"},{"key":"2020022801311882800_R3","doi-asserted-by":"crossref","unstructured":"John M, Goodman W, Gao P, Cantor T, Salusky I, Ju\u0308ppner H. A novel immunoradiometric assay detects full-length human PTH but not amino-terminally truncated fragments: implication for PTH measurements in renal failure. J Clin Endocrinol Metab1999;84:4287-4290.","DOI":"10.1210\/jcem.84.11.6236"},{"key":"2020022801311882800_R4","doi-asserted-by":"crossref","unstructured":"Boudou P, Ibrahim F, Cormier C, Chabas A, Sarfati E, Souberbielle JC. Third- or second-generation PTH assays: a remaining debate in the diagnosis of primary hyperparathyroidism. J Clin Endocrinol Metab2005;90:6370-6372.","DOI":"10.1210\/jc.2005-0715"},{"key":"2020022801311882800_R5","doi-asserted-by":"crossref","unstructured":"Inaba M, Nakatsuka K, Imananishi Y, Watanabe M, Mamiya Y, Ishimura E, et al. Technical and clinical characterization of the Bio-PTH (1\u201384) immunochemiluminometric assay and comparison with a second generation assay for parathyroid hormone. Clin Chem2004;50:385-390.","DOI":"10.1373\/clinchem.2003.026831"},{"key":"2020022801311882800_R6","doi-asserted-by":"crossref","unstructured":"Carnevale V, Dionisi S, Nofroni I, Romagnoli E, Paglia F, De Geronimo S, et al. Potential utility of a new IRMA for parathyroid hormone in postmenopausal patients with primary hyperparathyroidism. Clin Chem2004;50:626-631.","DOI":"10.1373\/clinchem.2003.026328"},{"key":"2020022801311882800_R7","doi-asserted-by":"crossref","unstructured":"Silverberg S, Gao P, Brown I, LoGerfo P, Cantor T, Bilezikian J. Clinical utility of an immunoradiometric assay for parathyroid hormone (1\u201384) in primary hyperparathyroidism. J Clin Endocrinol Metab2003;88:4725-4730.","DOI":"10.1210\/jc.2002-021266"},{"key":"2020022801311882800_R8","doi-asserted-by":"crossref","unstructured":"Koller H, Zitt E, Staudacher G, Neyer U, Mayer G, Rosenkranz A. Variable parathyroid hormone (1\u201384)\/carboxyl-terminal PTH ratios detected by 4 novel parathyroid hormone assays. Clin Nephrol2004;61:337-343.","DOI":"10.5414\/CNP61337"},{"key":"2020022801311882800_R9","unstructured":"Rubin M, D\u2019Amour P, Cantor T, Bilezikian J, Silverberg S. A molecular form of PTH distinct from PTH (1\u201384) is produced in parathyroid carcinoma. J Bone Miner Res2004;19(Suppl 1):S327."},{"key":"2020022801311882800_R10","doi-asserted-by":"crossref","unstructured":"Ra\u0308kel A, Brossard JH, Patenaude JV, Albert C, Nassif E, Cantor T, et al. Overproduction of an amino-terminal form of PTH distinct from human PTH(1\u201384) in a case of severe primary hyperparathyroidism: influence of medical treatment and surgery. Clin Endocrinol2005;62:721-727.","DOI":"10.1111\/j.1365-2265.2005.02286.x"},{"key":"2020022801311882800_R11","doi-asserted-by":"crossref","unstructured":"Reichel H, Esser A, Roth HJ, Schmidt-Gayk H. Influence of PTH assay methodology on differential diagnosis of renal bone disease. Nephrol Dial Transplant2003;18:759-768.","DOI":"10.1093\/ndt\/gfg144"},{"key":"2020022801311882800_R12","doi-asserted-by":"crossref","unstructured":"D\u2019Amour P, Brossard JH, Rousseau L, Roy L, Gao P, Cantor T. Amino-terminal form of parathyroid hormone (PTH) with immunologic similarities to hPTH(1\u201384) is overproduced in primary and secondary hyperparathyroidism. 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