{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T15:25:43Z","timestamp":1790522743056,"version":"4.1.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Background: Breastfeeding may protect children from developing metabolic syndrome and other diseases later in life. We investigated novel proteins in human breast milk that might play a role in this process.<\/jats:p><jats:p>Methods: We used ELISA to measure adiponectin, adipocyte and epidermal fatty acid binding proteins (AFABP, EFABP), and leptin concentrations in human breast milk obtained from 59 mothers 48 h after initiation of lactation. Using a questionnaire and medical records, we collected information about the mothers and newborns.<\/jats:p><jats:p>Results: Mean (SE) adiponectin concentrations in breast milk were 13.7 (0.8), range 3.9\u201330.4 \u03bcg\/L; AFABP concentrations 26.7 (4.4), range 1.2\u2013137.0 \u03bcg\/L; EFABP concentrations 18.1 (1.4), range 0.8\u201347.0 \u03bcg\/L; and leptin concentrations 0.50 (0.05), range 0\u20131.37 \u03bcg\/L. We found a significant correlation between AFABP and EFABP concentrations (r = 0.593, P &amp;lt;0.0001). Maternal EFABP concentrations were significantly higher in mothers who delivered boys than in those who delivered girls [21.7 (2.3) vs 15.4 (1.7) \u03bcg\/L, P = 0.028] and correlated with newborn birth weight (r = 0.266, P = 0.045). Maternal leptin correlated with body weight before pregnancy (r = 0.272, P = 0.043) and at delivery (r = 0.370, P = 0.005), body mass index before pregnancy (r = 0.397, P = 0.003) and at delivery (r = 0.498, P &amp;lt;0.0001), body weight gain during pregnancy (r = 0.267, P = 0.047), and newborn gestational age (r = 0.266, P = 0.048). Leptin was significantly lower in mothers who delivered preterm vs term babies [0.30 (0.09) vs 0.60 (0.05) ug\/L, P = 0.026].<\/jats:p><jats:p>Conclusions: Concentrations of adiponectin, AFABP, and EFABP in human breast milk are related to nutritional variables of mothers and newborns and thus may play a role in the protective effects of breastfeeding.<\/jats:p>","DOI":"10.1373\/clinchem.2005.063032","type":"journal-article","created":{"date-parts":[[2006,7,28]],"date-time":"2006-07-28T00:54:28Z","timestamp":1154048068000},"page":"1763-1770","source":"Crossref","is-referenced-by-count":61,"title":["Adiponectin, Adipocyte Fatty Acid Binding Protein, and Epidermal Fatty Acid Binding Protein: Proteins Newly Identified in Human Breast Milk"],"prefix":"10.1093","volume":"52","author":[{"given":"Jir\u030ci\u0301","family":"Bronsky\u0301","sequence":"first","affiliation":[{"name":"Pediatric Gastroenterology Unit, Pediatric Clinic, 2nd Medical Faculty, Charles University and University Hospital Motol, Prague, Czech Republic"},{"name":"Department of Clinical Biochemistry and Pathobiochemistry, 2nd Medical Faculty, Charles University and University Hospital Motol, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Karpi\u0301s\u030cek","sequence":"first","affiliation":[{"name":"Department of Human Pharmacology and Toxicology, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Bronska\u0301","sequence":"first","affiliation":[{"name":"National Institute of Public Health and 3rd Medical Faculty, Charles University and University Hospital Bulovka, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Pechova\u0301","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry and Pathobiochemistry, 2nd Medical Faculty, Charles University and University Hospital Motol, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbora","family":"Janc\u030ci\u0301kova\u0301","sequence":"first","affiliation":[{"name":"Department of Neonatology, 2nd Medical Faculty, Charles University and University Hospital Motol, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hana","family":"Kotolova\u0301","sequence":"first","affiliation":[{"name":"Department of Human Pharmacology and Toxicology, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Stejskal","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Hospital S\u030cternberk, S\u030cternberk, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Pru\u030as\u030ca","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry and Pathobiochemistry, 2nd Medical Faculty, Charles University and University Hospital Motol, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jir\u030ci\u0301","family":"Nevoral","sequence":"first","affiliation":[{"name":"Pediatric Gastroenterology Unit, Pediatric Clinic, 2nd Medical Faculty, Charles University and University Hospital Motol, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,9,1]]},"reference":[{"key":"2020022801250785100_R1","doi-asserted-by":"crossref","unstructured":"Barker DJP, Clark PM. 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