{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T04:31:16Z","timestamp":1789446676613,"version":"build-2803163510"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background: The aim of the present study was to assess the utility of amino-terminal pro-A-type natriuretic peptide (NT-proANP) measurements for the emergency diagnosis of acute destabilized heart failure (HF), using a novel sandwich immunoassay covering midregional epitopes (MR-proANP).<\/jats:p>\n                  <jats:p>Methods: The retrospective analysis comprised 251 consecutive patients presenting to the emergency department of a tertiary care hospital with dyspnea as a chief complaint. The diagnosis of acute destabilized HF was based on the Framingham score for HF plus echocardiographic evidence of systolic or diastolic dysfunction. A commercially available immunoluminometric assay was used for measurement of MR-proANP plasma concentrations.<\/jats:p>\n                  <jats:p>Results: Median MR-proANP plasma concentrations were significantly higher in patients with dyspnea attributable to acute destabilized HF (338 pmol\/L; n = 137) than in patients with dyspnea attributable to other reasons (98 pmol\/L; n = 114; P &amp;lt;0.001). The area under the curve for MR-proANP was 0.876 (SE = 0.022; 95% confidence interval, 0.829\u20130.914), and the cutoff concentration with the highest diagnostic accuracy was 169 pmol\/L (sensitivity, 89%; specificity, 76%; diagnostic accuracy, 83%). In the setting evaluated, diagnostic information obtained by MR-proANP measurements was similar to that obtained with B-type natriuretic peptide (BNP) and amino-terminal proBNP (NT-proBNP) measurements.<\/jats:p>\n                  <jats:p>Conclusions: MR-proANP measurements may be useful as an aid in the diagnosis of acute destabilized HF in short-of-breath patients presenting to an emergency department. The diagnostic value of MR-proANP appears to be comparable to that of BNP and NT-proBNP.<\/jats:p>","DOI":"10.1373\/clinchem.2005.065441","type":"journal-article","created":{"date-parts":[[2006,3,16]],"date-time":"2006-03-16T20:33:33Z","timestamp":1142541213000},"page":"827-831","source":"Crossref","is-referenced-by-count":84,"title":["Midregional Pro-A-Type Natriuretic Peptide Measurements for Diagnosis of Acute Destabilized Heart Failure in Short-of-Breath Patients: Comparison with B-Type Natriuretic Peptide (BNP) and Amino-Terminal proBNP"],"prefix":"10.1093","volume":"52","author":[{"given":"Alfons","family":"Gegenhuber","sequence":"first","affiliation":[{"name":"Departments of Internal Medicine and Laboratory Medicine, Konventhospital Barmherzige Brueder, Linz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Struck","sequence":"first","affiliation":[{"name":"Research Department, B.R.A.H.M.S AG, Hennigsdorf\/Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Poelz","sequence":"first","affiliation":[{"name":"Institute for Applied System Sciences and Statistics, University of Linz, Linz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Pacher","sequence":"first","affiliation":[{"name":"Department of Cardiology, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils G","family":"Morgenthaler","sequence":"first","affiliation":[{"name":"Research Department, B.R.A.H.M.S AG, Hennigsdorf\/Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Bergmann","sequence":"first","affiliation":[{"name":"Research Department, B.R.A.H.M.S AG, Hennigsdorf\/Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meinhard","family":"Haltmayer","sequence":"first","affiliation":[{"name":"Departments of Internal Medicine and Laboratory Medicine, Konventhospital Barmherzige Brueder, Linz, Austria"},{"name":"Paracelsus Private Medical University, Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Mueller","sequence":"first","affiliation":[{"name":"Departments of Internal Medicine and Laboratory Medicine, Konventhospital Barmherzige Brueder, Linz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,5,1]]},"reference":[{"key":"2020022801250200700_R1","doi-asserted-by":"crossref","unstructured":"Clerico A, Del Ry S, Giannessi D. Measurement of cardiac natriuretic hormones (atrial natriuretic peptide, brain natriuretic peptide, and related peptide) in clinical practice: the need for a new generation of immunoassay methods [Review]. Clin Chem2000;46:1529-1534.","DOI":"10.1093\/clinchem\/46.10.1529"},{"key":"2020022801250200700_R2","doi-asserted-by":"crossref","unstructured":"Cowie MR, Jourdain P, Maisel A, Dahlstrom U, Follath F, Isnard R, et al. Clinical applications of B-type natriuretic peptide (BNP) testing [Review]. Eur Heart J2003;24:1710-1718.","DOI":"10.1016\/S0195-668X(03)00476-7"},{"key":"2020022801250200700_R3","doi-asserted-by":"crossref","unstructured":"Mair J. Role of cardiac natriuretic peptide testing in heart failure [Editorial]. Clin Chem2002;48:977-978.","DOI":"10.1093\/clinchem\/48.7.977"},{"key":"2020022801250200700_R4","doi-asserted-by":"crossref","unstructured":"Ala-Kopsala M, Magga J, Peuhkurinen K, Leipala J, Ruskoaho H, Leppaluoto J, et al. 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Brain natriuretic peptide and n-terminal brain natriuretic peptide in the diagnosis of heart failure in patients with acute shortness of breath. J Am Coll Cardiol2003;42:728-735.","DOI":"10.1016\/S0735-1097(03)00787-3"},{"key":"2020022801250200700_R8","doi-asserted-by":"crossref","unstructured":"Mueller T, Gegenhuber A, Poelz W, Haltmayer M. Diagnostic accuracy of B type natriuretic peptide and amino terminal proBNP in the emergency diagnosis of heart failure. Heart2005;91:606-612.","DOI":"10.1136\/hrt.2004.037762"},{"key":"2020022801250200700_R9","doi-asserted-by":"crossref","unstructured":"Senni M, Tribouilloy CM, Rodeheffer RJ, Jacobsen SJ, Evans JM, Bailey KR, et al. Congestive heart failure in the community: a study of all incident cases in Olmsted County, Minnesota, in 1991. Circulation1998;98:2282-2289.","DOI":"10.1161\/01.CIR.98.21.2282"},{"key":"2020022801250200700_R10","doi-asserted-by":"crossref","unstructured":"Morgenthaler NG, Struck J, Thomas B, Bergmann A. 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