{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T17:04:19Z","timestamp":1771002259319,"version":"3.50.1"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Background: Variability among assays used to measure intact parathyroid hormone (iPTH) is of particular concern because of the routine use of iPTH assay results to guide management of osteodystrophy and calcium metabolism in patients with end-stage renal disease (ESRD). The aim of this study was to determine the extent to which results from commercially available iPTH assays diverge from results obtained with the Nichols Allegro\u00ae Intact PTH immunoradiometric assay (IRMA), which was used as evidence in the development of the National Kidney Foundation\u2019s Kidney Disease Outcomes Quality Initiative Clinical Practice Guidelines.<\/jats:p>\n               <jats:p>Methods: We divided EDTA plasma from 46 dialysis patients with ESRD and measured iPTH values with the following commercially available iPTH assays: Nichols\u2019 Allegro iPTH IRMA, Nichols Advantage\u00ae iPTH immunochemiluminescent assay (ICMA), Scantibodies\u2019 Total Intact PTH\u2122 IRMA, DiaSorin\u2019s N-tact\u00ae iPTH IRMA, DPC\u2019s Coat-A-Count\u00ae iPTH IRMA, Roche\u2019s Elecsys\u00ae iPTH ICMA, and DSL\u2019s Active\u00ae iPTH IRMA.<\/jats:p>\n               <jats:p>Results: Method comparison showed considerable interassay differences in the measurement of iPTH in ESRD patients. IPTH values assessed by other methods ranged, on average, from 60% to 152% of the Nichols Allegro IRMA values. Of the 6 iPTH assays tested, only the Scantibodies Total Intact PT IRMA (P = 0.7554) and the Roche Elecsys iPTH ICMA (P = 0.1327) resulted in iPTH values not statistically different from those obtained with the Nichols Allegro iPTH IRMA.<\/jats:p>\n               <jats:p>Conclusions: Noncomparability among iPTH assays remains a distinct problem for the management of ESRD patients. These results should be taken into consideration when determining the course of medical treatment based on measured iPTH concentrations<\/jats:p>","DOI":"10.1373\/clinchem.2006.071589","type":"journal-article","created":{"date-parts":[[2006,7,21]],"date-time":"2006-07-21T01:04:43Z","timestamp":1153443883000},"page":"1771-1776","source":"Crossref","is-referenced-by-count":66,"title":["Lack of Comparability of Intact Parathyroid Hormone Measurements among Commercial Assays for End-Stage Renal Disease Patients: Implication for Treatment Decisions"],"prefix":"10.1093","volume":"52","author":[{"given":"Tom","family":"Cantor","sequence":"first","affiliation":[{"name":"Scantibodies Laboratory, Inc., Santee, CA"},{"name":"Scantibodies Clinical Laboratory, Inc., Santee, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zan","family":"Yang","sequence":"first","affiliation":[{"name":"Scantibodies Laboratory, Inc., Santee, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolae","family":"Caraiani","sequence":"first","affiliation":[{"name":"Suffolk Nephrology Consultants, Stony Brook, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ekambaram","family":"Ilamathi","sequence":"first","affiliation":[{"name":"Suffolk Nephrology Consultants, Stony Brook, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2006,9,1]]},"reference":[{"key":"2020022801253661700_R1","unstructured":". 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