{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T22:42:06Z","timestamp":1791153726532,"version":"4.1.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000862","name":"Doris Duke Charitable Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000862","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001674","name":"Fondation Leducq","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001674","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002429","name":"Amgen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002429","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The primary aim of the Women\u2019s Genome Health Study (WGHS) is to create a comprehensive, fully searchable genome-wide database of &amp;gt;360 000 single nucleotide polymorphisms among at least 25 000 initially healthy American women participating in the ongoing NIH-funded Women\u2019s Health Study (WHS). These women have already been followed over a 12-year period for major incident health events including but not limited to myocardial infarction, stroke, cancer, diabetes, osteoporosis, venous-thromboembolism, cognitive decline, and common visual disorders such as age- related macular degeneration and cataracts. Investigations within the WGHS will seek to identify relevant patterns of genetic polymorphism that predict future disease states in otherwise healthy American women, and to evaluate patterns of genetic polymorphism that relate to multiple intermediate phenotypes including blood-based determinants of disease that were measured at baseline for each study participant. By linking genome-wide data to the existing epidemiologic databank of the parent WHS, which includes comprehensive dietary, behavioral, and traditional exposure data on each participant since cohort inception in 1992, the WGHS will also allow exploration of gene-environment and gene-gene interactions as they relate to incident disease states. Thus, with continued follow-up of the WHS, the WGHS provides a unique scientific resource\u2014a full-cohort, prospective, genome-wide association study among initially healthy American women.<\/jats:p>","DOI":"10.1373\/clinchem.2007.099366","type":"journal-article","created":{"date-parts":[[2007,12,10]],"date-time":"2007-12-10T20:24:46Z","timestamp":1197318286000},"page":"249-255","source":"Crossref","is-referenced-by-count":150,"title":["Rationale, Design, and Methodology of the Women\u2019s Genome Health Study: A Genome-Wide Association Study of More Than 25 000 Initially Healthy American Women"],"prefix":"10.1093","volume":"54","author":[{"given":"Paul M","family":"Ridker","sequence":"first","affiliation":[{"name":"Center for Cardiovascular Disease Prevention, Brigham and Women\u2019s Hospital, Boston"},{"name":"Donald W Reynolds Center for Cardiovascular Research, Harvard Medical School, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel I","family":"Chasman","sequence":"first","affiliation":[{"name":"Center for Cardiovascular Disease Prevention, Brigham and Women\u2019s Hospital, Boston"},{"name":"Donald W Reynolds Center for Cardiovascular Research, Harvard Medical School, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert Y L","family":"Zee","sequence":"first","affiliation":[{"name":"Center for Cardiovascular Disease Prevention, Brigham and Women\u2019s Hospital, Boston"},{"name":"Donald W Reynolds Center for Cardiovascular Research, Harvard Medical School, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Parker","sequence":"first","affiliation":[{"name":"Amgen, Inc, Cambridge, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynda","family":"Rose","sequence":"first","affiliation":[{"name":"Center for Cardiovascular Disease Prevention, Brigham and Women\u2019s Hospital, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy R","family":"Cook","sequence":"first","affiliation":[{"name":"Center for Cardiovascular Disease Prevention, Brigham and Women\u2019s Hospital, Boston"},{"name":"Donald W Reynolds Center for Cardiovascular Research, Harvard Medical School, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie E","family":"Buring","sequence":"first","affiliation":[{"name":"Center for Cardiovascular Disease Prevention, Brigham and Women\u2019s Hospital, Boston"},{"name":"Donald W Reynolds Center for Cardiovascular Research, Harvard Medical School, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Women\u2019s Genome Health Study Working Group","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,2,1]]},"reference":[{"key":"2020022800133488300_R1","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1056\/NEJMp068126","volume":"356","year":"2007","journal-title":"N Engl J Med"},{"key":"2020022800133488300_R2","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1126\/science.274.5287.536","volume":"274","year":"1996","journal-title":"Science (Wash DC)"},{"key":"2020022800133488300_R3","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/nrg1521","volume":"6","year":"2005","journal-title":"Nature (Lond) Rev Genet"},{"key":"2020022800133488300_R4","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nature05911","volume":"447","year":"2007","journal-title":"Nature (Lond)"},{"key":"2020022800133488300_R5","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1126\/science.1142382","volume":"316","year":"2007","journal-title":"Science (Wash DC)"},{"key":"2020022800133488300_R6","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1126\/science.1142358","volume":"316","year":"2007","journal-title":"Science (Wash DC)"},{"key":"2020022800133488300_R7","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1056\/NEJMoa072366","volume":"357","year":"2007","journal-title":"N Engl J Med"},{"key":"2020022800133488300_R8","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1126\/science.1142447","volume":"316","year":"2007","journal-title":"Science (Wash DC)"},{"key":"2020022800133488300_R9","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1126\/science.1142842","volume":"316","year":"2007","journal-title":"Science (Wash DC)"},{"key":"2020022800133488300_R10","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1038\/nature04226","volume":"437","year":"2005","journal-title":"Nature (Lond)"},{"key":"2020022800133488300_R11","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1089\/152460900318911","volume":"9","year":"2000","journal-title":"J Womens Health Gend Based Med"},{"key":"2020022800133488300_R12","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1056\/NEJMoa050613","volume":"352","year":"2005","journal-title":"N Engl J Med"},{"key":"2020022800133488300_R13","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1001\/jama.294.1.56","volume":"294","year":"2005","journal-title":"JAMA"},{"key":"2020022800133488300_R14","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1001\/jama.294.1.47","volume":"294","year":"2005","journal-title":"JAMA"},{"key":"2020022800133488300_R15","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1001\/jama.286.3.327","volume":"286","year":"2001","journal-title":"JAMA"},{"key":"2020022800133488300_R16","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.1001\/jama.290.22.2945","volume":"290","year":"2003","journal-title":"JAMA"},{"key":"2020022800133488300_R17","first-page":"987","volume":"12","year":"2007","journal-title":"BMJ"},{"key":"2020022800133488300_R18"},{"key":"2020022800133488300_R19","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1001\/jama.297.6.611","volume":"297","year":"2007","journal-title":"JAMA"},{"key":"2020022800133488300_R20","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1001\/jama.294.3.326","volume":"294","year":"2005","journal-title":"JAMA"},{"key":"2020022800133488300_R21","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1001\/jama.298.3.309","volume":"298","year":"2007","journal-title":"JAMA"},{"key":"2020022800133488300_R22","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1056\/NEJMoa021993","volume":"347","year":"2002","journal-title":"N Engl J Med"},{"key":"2020022800133488300_R23","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1001\/jama.296.11.1363","volume":"296","year":"2006","journal-title":"JAMA"},{"key":"2020022800133488300_R24","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1373\/clinchem.2006.083881","volume":"53","year":"2007","journal-title":"Clin Chem"},{"key":"2020022800133488300_R25","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1161\/CIRCULATIONAHA.106.634089","volume":"114","year":"2006","journal-title":"Circulation"},{"key":"2020022800133488300_R26","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1056\/NEJM200003233421202","volume":"342","year":"2000","journal-title":"N Engl J Med"},{"key":"2020022800133488300_R27","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0076-6879(06)10017-8","volume":"410","year":"2006","journal-title":"Methods Enzymol"},{"key":"2020022800133488300_R28","doi-asserted-by":"crossref","first-page":"641","DOI":"10.2217\/14622416.7.4.641","volume":"7","year":"2006","journal-title":"Pharmacogenomics"},{"key":"2020022800133488300_R29","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/nrg1522","volume":"6","year":"2005","journal-title":"Nature (Lond) Rev Genetics"},{"key":"2020022800133488300_R30","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/nrg1916","volume":"7","year":"2006","journal-title":"Nature (Lond) Rev Genetics"},{"key":"2020022800133488300_R31","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/447655a","volume":"447","year":"2007","journal-title":"Nature (Lond)"}],"container-title":["Clinical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/clinchem\/article-pdf\/54\/2\/249\/32671808\/clinchem0249.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/clinchem\/article-pdf\/54\/2\/249\/32671808\/clinchem0249.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T00:14:47Z","timestamp":1582848887000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/clinchem\/article\/54\/2\/249\/5628724"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2,1]]},"references-count":31,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2008,2,1]]},"published-print":{"date-parts":[[2008,2,1]]}},"URL":"https:\/\/doi.org\/10.1373\/clinchem.2007.099366","relation":{},"ISSN":["0009-9147","1530-8561"],"issn-type":[{"value":"0009-9147","type":"print"},{"value":"1530-8561","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2008,2,1]]},"published":{"date-parts":[[2008,2,1]]}}}