{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T12:04:56Z","timestamp":1772021096994,"version":"3.50.1"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Background: C-reactive protein (CRP), a sensitive marker of the acute-phase response, has been associated with future cardiovascular endpoints independently of other risk factors. A joint analysis of the role of risk factors in predicting mean concentrations and variation of high-sensitivity CRP (hsCRP) in serum has not been carried out previously.<\/jats:p>\n               <jats:p>Methods: We used data from 1003 myocardial infarction (MI) survivors who had hsCRP measured monthly up to 8 times and multivariate mixed effects statistical models to study the role of time-variant and -invariant factors on the geometric mean of and the intraindividual variation in hsCRP concentrations.<\/jats:p>\n               <jats:p>Results: Patients with \u22656.5% glycosylated hemoglobin (HbA1c) had 26.2% higher hsCRP concentrations (95% CI, 7.2%\u201348.6%) and 20.7% greater variation in hsCRP values (P = 0.0034) than patients with lower baseline Hb A1c values (&amp;lt;6.5%). Similar but less pronounced differences were seen in patients with a self-reported diagnosis of type 2 diabetes. hsCRP concentrations showed less variation in patients who reported angina pectoris, congestive heart failure, or emphysema (\u221211.0%, \u221224.9%, and \u221241.6%, respectively, vs patients without these conditions) but greater variation in males and smokers (+24.8% and +27.3%, respectively, vs females and nonsmokers). Exposures in the 24 h before blood sampling, including exposure to environmental tobacco smoke, alcohol consumption, and extreme stress, did not have a major impact.<\/jats:p>\n               <jats:p>Conclusions: One or 2 hsCRP measurements may not be sufficient to adequately characterize different patient groups after MI with similar precisions. We found hsCRP concentrations to be especially variable in males, smokers, and patients with increased Hb A1c values.<\/jats:p>","DOI":"10.1373\/clinchem.2008.112334","type":"journal-article","created":{"date-parts":[[2008,12,19]],"date-time":"2008-12-19T01:35:39Z","timestamp":1229650539000},"page":"322-335","source":"Crossref","is-referenced-by-count":18,"title":["Determinants of the Acute-Phase Protein C-Reactive Protein in Myocardial Infarction Survivors: The Role of Comorbidities and Environmental Factors"],"prefix":"10.1093","volume":"55","author":[{"given":"Regina","family":"Ru\u0308ckerl","sequence":"first","affiliation":[{"name":"Helmholtz Zentrum Mu\u0308nchen, German Research Center for Environmental Health, Institute of Epidemiology, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annette","family":"Peters","sequence":"first","affiliation":[{"name":"Helmholtz Zentrum Mu\u0308nchen, German Research Center for Environmental Health, Institute of Epidemiology, Munich, Germany"},{"name":"Helmholtz Zentrum Mu\u0308nchen, German Research Center for Environmental Health, Focus-Network Nanoparticles and Health (NanoHealth), Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie","family":"Khuseyinova","sequence":"first","affiliation":[{"name":"Department of Internal Medicine II, Cardiology, University of Ulm Medical Center, Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariarita","family":"Andreani","sequence":"first","affiliation":[{"name":"Local Health Authority RM E, Department of Epidemiology ASL RME, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Koenig","sequence":"first","affiliation":[{"name":"Department of Internal Medicine II, Cardiology, University of Ulm Medical Center, Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christa","family":"Meisinger","sequence":"first","affiliation":[{"name":"Helmholtz Zentrum Mu\u0308nchen, German Research Center for Environmental Health, Institute of Epidemiology, Munich, Germany"},{"name":"Central Hospital of Augsburg, MONICA\/KORA Myocardial Infarction Registry, Augsburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantina","family":"Dimakopoulou","sequence":"first","affiliation":[{"name":"Department of Hygiene and Epidemiology, University of Athens Medical School, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordi","family":"Sunyer","sequence":"first","affiliation":[{"name":"Center for Research in Environmental Epidemiology (CREAL)"},{"name":"Municipal Institute of Medical Research (IMIM-Hospital del Mar)"},{"name":"CIBER Epidemiologi\u0300a y Salud Pu\u0301blica (CIBERESP), and"},{"name":"Universitat Pompeu Fabra (UPF), Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timo","family":"Lanki","sequence":"first","affiliation":[{"name":"Environmental Epidemiology Unit, National Public Health Institute (KTL), Kuopio, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fredrik","family":"Nyberg","sequence":"first","affiliation":[{"name":"Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden"},{"name":"AstraZeneca R&D, Mo\u0308lndal, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Schneider","sequence":"first","affiliation":[{"name":"Helmholtz Zentrum Mu\u0308nchen, German Research Center for Environmental Health, Institute of Epidemiology, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2009,2,1]]},"reference":[{"key":"2020022800261132400_R1","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/S0140-6736(96)07591-5","volume":"349","year":"1997","journal-title":"Lancet"},{"key":"2020022800261132400_R2","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1056\/NEJM199704033361401","volume":"336","year":"1997","journal-title":"N Engl J Med"},{"key":"2020022800261132400_R3","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1161\/01.CIR.99.2.237","volume":"99","year":"1999","journal-title":"Circulation"},{"key":"2020022800261132400_R4","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1161\/01.CIR.0000053731.05365.5A","volume":"107","year":"2003","journal-title":"Circulation"},{"key":"2020022800261132400_R5","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1161\/01.CIR.0000052939.59093.45","volume":"107","year":"2003","journal-title":"Circulation"},{"key":"2020022800261132400_R6","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1016\/j.ehj.2004.09.032","volume":"25","year":"2004","journal-title":"Eur Heart J"},{"key":"2020022800261132400_R7","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1111\/j.1464-5491.2006.01912.x","volume":"23","year":"2006","journal-title":"Diabet Med"},{"key":"2020022800261132400_R8","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1161\/01.CIR.100.8.793","volume":"100","year":"1999","journal-title":"Circulation"},{"key":"2020022800261132400_R9","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0021-9150(00)00590-6","volume":"155","year":"2001","journal-title":"Atherosclerosis"},{"key":"2020022800261132400_R10","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1161\/01.CIR.103.9.1191","volume":"103","year":"2001","journal-title":"Circulation"},{"key":"2020022800261132400_R11","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/S0195-668X(03)00260-4","volume":"24","year":"2003","journal-title":"Eur Heart J"},{"key":"2020022800261132400_R12","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1161\/01.CIR.0000130640.77501.79","volume":"109","year":"2004","journal-title":"Circulation"},{"key":"2020022800261132400_R13","first-page":"303","volume":"26","year":"2007","journal-title":"J Sports Sci"},{"key":"2020022800261132400_R14","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1139\/h05-115","volume":"30","year":"2005","journal-title":"Can J Appl Physiol"},{"key":"2020022800261132400_R15","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.atherosclerosis.2005.04.011","volume":"184","year":"2006","journal-title":"Atherosclerosis"},{"key":"2020022800261132400_R16","doi-asserted-by":"crossref","first-page":"3914","DOI":"10.1210\/jc.2004-2346","volume":"90","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"2020022800261132400_R17","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.1055\/s-2005-858241","volume":"67","year":"2005","journal-title":"Gesundheitswesen"},{"key":"2020022800261132400_R18","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1053\/euhj.2000.2305","volume":"21","year":"2000","journal-title":"Eur Heart J"},{"key":"2020022800261132400_R19","first-page":"161","volume":"19 Suppl 1","year":"2007","journal-title":"Inhal Toxicol"},{"key":"2020022800261132400_R20","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1177\/096228029900800204","volume":"8","year":"1999","journal-title":"Stat Methods Med Res"},{"key":"2020022800261132400_R21","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3109\/10408368909106595","volume":"27","year":"1989","journal-title":"Crit Rev Clin Lab Sci"},{"key":"2020022800261132400_R22","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1093\/aje\/kwg135","volume":"158","year":"2003","journal-title":"Am J Epidemiol"},{"key":"2020022800261132400_R23","first-page":"p 201","year":"2006","journal-title":"Proceedings of the 21st International Workshop on Statistical Modelling; 2006 Jul 3\u20137; Galway, Ireland"},{"key":"2020022800261132400_R24","first-page":"i\u2013253","volume":"894","year":"2000","journal-title":"World Health Organ Tech Rep Ser"},{"key":"2020022800261132400_R25","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1038\/sj.ijo.0803182","volume":"30","year":"2006","journal-title":"Int J Obes (Lond)"},{"key":"2020022800261132400_R26","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1093\/clinchem\/46.7.934","volume":"46","year":"2000","journal-title":"Clin Chem"},{"key":"2020022800261132400_R27","doi-asserted-by":"crossref","first-page":"352","DOI":"10.5414\/CNP67352","volume":"67","year":"2007","journal-title":"Clin Nephrol"},{"key":"2020022800261132400_R28","doi-asserted-by":"crossref","first-page":"116S","DOI":"10.1378\/chest.121.5_suppl.116S","volume":"121","year":"2002","journal-title":"Chest"},{"key":"2020022800261132400_R29","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1172\/JCI200318921","volume":"111","year":"2003","journal-title":"J Clin Invest"},{"key":"2020022800261132400_R30","first-page":"1250","volume":"29","year":"2007","journal-title":"Eur Heart J"},{"key":"2020022800261132400_R31","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1056\/NEJM200011093431902","volume":"343","year":"2000","journal-title":"N Engl J Med"},{"key":"2020022800261132400_R32","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1161\/01.CIR.92.7.1720","volume":"92","year":"1995","journal-title":"Circulation"},{"key":"2020022800261132400_R33","doi-asserted-by":"crossref","first-page":"2684","DOI":"10.1161\/CIRCULATIONAHA.104.492215","volume":"111","year":"2005","journal-title":"Circulation"},{"key":"2020022800261132400_R34","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1136\/oem.2005.023911","volume":"63","year":"2006","journal-title":"Occup Environ Med"},{"key":"2020022800261132400_R35","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.1161\/01.CIR.103.23.2810","volume":"103","year":"2001","journal-title":"Circulation"},{"key":"2020022800261132400_R36","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1016\/S0140-6736(97)01211-7","volume":"349","year":"1997","journal-title":"Lancet"},{"key":"2020022800261132400_R37","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1097\/01.ede.0000112210.68754.fa","volume":"15","year":"2004","journal-title":"Epidemiology"},{"key":"2020022800261132400_R38","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1093\/gerona\/60.6.760","volume":"60","year":"2005","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"2020022800261132400_R39","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1136\/jcp.36.2.203","volume":"36","year":"1983","journal-title":"J Clin Pathol"},{"key":"2020022800261132400_R40","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.atherosclerosis.2005.12.028","volume":"189","year":"2006","journal-title":"Atherosclerosis"}],"container-title":["Clinical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/clinchem\/article-pdf\/55\/2\/322\/32674197\/clinchem0322.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/clinchem\/article-pdf\/55\/2\/322\/32674197\/clinchem0322.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T05:30:10Z","timestamp":1582867810000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/clinchem\/article\/55\/2\/322\/5631721"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2,1]]},"references-count":40,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2009,2,1]]},"published-print":{"date-parts":[[2009,2,1]]}},"URL":"https:\/\/doi.org\/10.1373\/clinchem.2008.112334","relation":{},"ISSN":["0009-9147","1530-8561"],"issn-type":[{"value":"0009-9147","type":"print"},{"value":"1530-8561","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2009,2,1]]},"published":{"date-parts":[[2009,2,1]]}}}