{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T13:46:44Z","timestamp":1781531204255,"version":"3.54.5"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Background: Evidence is accumulating that vitamin D supplementation of patients with low 25-hydroxyvitamin D concentrations is associated with lower cardiovascular morbidity and total mortality during long-term follow-up. Little is known, however, about the effect of low concentrations of the vitamin D hormone calcitriol on total mortality. We therefore evaluated the predictive value of circulating calcitriol for midterm mortality in patients of a specialized heart center.<\/jats:p>\n               <jats:p>Methods: This prospective cohort study included 510 patients, 67.7% with heart failure (two-thirds in end stage), 64.3% hypertension, 33.7% coronary heart disease, 20.2% diabetes, and 17.3% renal failure. We followed the patients for up to 1 year after blood collection. For data analysis, the study cohort was stratified into quintiles of circulating calcitriol concentrations.<\/jats:p>\n               <jats:p>Results: Patients in the lowest calcitriol quintile were more likely to have coronary heart disease, heart failure, hypertension, diabetes, and renal failure compared to other patients. They also had low 25-hydroxyvitamin D concentrations and high concentrations of creatinine, C-reactive protein, and tumor necrosis factor \u03b1. Eighty-two patients (16.0%) died during follow-up. Probability of 1-year survival was 66.7% in the lowest calcitriol quintile, 82.2% in the second quintile, 86.7% in the intermediate quintile, 88.8% in the fourth quintile, and 96.1% in the highest quintile (P &amp;lt; 0.001). Discrimination between survivors and nonsurvivors was best when a cutoff value of 25 ng\/L was applied (area under the ROC curve 0.72; 95% CI 0.66\u20130.78).<\/jats:p>\n               <jats:p>Conclusions: Decreased calcitriol levels are linked to excess midterm mortality in patients of a specialized heart center. .<\/jats:p>","DOI":"10.1373\/clinchem.2008.120006","type":"journal-article","created":{"date-parts":[[2009,4,9]],"date-time":"2009-04-09T22:02:06Z","timestamp":1239314526000},"page":"1163-1170","source":"Crossref","is-referenced-by-count":82,"title":["Circulating Calcitriol Concentrations and Total Mortality"],"prefix":"10.1093","volume":"55","author":[{"given":"Armin","family":"Zittermann","sequence":"first","affiliation":[{"name":"Department of Cardio-Thoracic Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie S","family":"Schleithoff","sequence":"first","affiliation":[{"name":"Department of Cardio-Thoracic Surgery 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