{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T14:21:33Z","timestamp":1717597293646},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Background: Screening for fetal chromosome abnormalities in the first trimester includes analysis of the serological markers pregnancy-associated plasma protein A (PAPP-A) and free \u03b2 human choriogonadotropin (free \u03b2 hCG). The blood sample is traditionally taken around week 12 of gestation, but the performance of earlier blood sampling is not well documented.<\/jats:p>\n               <jats:p>Methods: We studied 44 537 singleton pregnancies. Complete first-trimester screening took place between November 2003 and March 2009, and blood samples were taken between 7 weeks + 5 days and 13 weeks + 6 days.<\/jats:p>\n               <jats:p>Results: Of 120 cases of trisomy 21, 108 were diagnosed in the first-trimester screening (detection rate 90%). When the blood sample was taken before gestational week 10, the detection rate of trisomy 21 was 97% (70 of 72), whereas 80% were detected (38 of 48) after week 10 (\u03c72 = 0.0035). For trisomy 18, trisomy 13, and triploidy, 65% (13 of 20) were detected before gestational week 10, and 73% (11 of 15) after (not significant). All 6 cases of triploidy before and after gestational week 10 were detected. The screen positive rate and the maternal age were similar before and after week 10 of gestation.<\/jats:p>\n               <jats:p>Conclusions: Screening for fetal aneuploidy can be performed with good results with the blood sample taken as early as week 7 of gestation. Blood samples taken before gestational week 10 showed a high detection rate of fetal trisomy 21, with no difference in the detection of fetal trisomy 18, trisomy 13, or triploidy.<\/jats:p>","DOI":"10.1373\/clinchem.2009.125922","type":"journal-article","created":{"date-parts":[[2009,6,19]],"date-time":"2009-06-19T01:52:26Z","timestamp":1245376346000},"page":"1564-1567","source":"Crossref","is-referenced-by-count":14,"title":["Performance of First-Trimester Screening between Gestational Weeks 7 and 13"],"prefix":"10.1093","volume":"55","author":[{"given":"Niels","family":"T\u00f8rring","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry, Aarhus University Hospital, Skejby, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2009,8,1]]},"reference":[{"key":"2020022800324911500_R1","first-page":"50","volume":"170","year":"2008","journal-title":"Ugeskr Laeger"},{"key":"2020022800324911500_R2","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/ajmg.c.30119","volume":"145C","year":"2007","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"2020022800324911500_R3","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1002\/uog.5331","volume":"31","year":"2008","journal-title":"Ultrasound Obstet Gynecol"},{"key":"2020022800324911500_R4","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1002\/(SICI)1097-0223(199906)19:6<505::AID-PD572>3.0.CO;2-6","volume":"19","year":"1999","journal-title":"Prenat Diagn"},{"key":"2020022800324911500_R5","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/j.ajog.2005.03.021","volume":"192","year":"2005","journal-title":"Am J Obstet Gynecol"},{"key":"2020022800324911500_R6","first-page":"363","volume":"71","year":"2006","journal-title":"Ceska Gynekol"},{"key":"2020022800324911500_R7","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1002\/pd.420","volume":"22","year":"2002","journal-title":"Prenat Diagn"},{"key":"2020022800324911500_R8","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1002\/(SICI)1097-0223(200005)20:5<411::AID-PD822>3.0.CO;2-2","volume":"20","year":"2000","journal-title":"Prenat Diagn"}],"container-title":["Clinical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/clinchem\/article-pdf\/55\/8\/1564\/32676034\/clinchem1564.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/clinchem\/article-pdf\/55\/8\/1564\/32676034\/clinchem1564.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T05:33:47Z","timestamp":1582868027000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/clinchem\/article\/55\/8\/1564\/5629238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8,1]]},"references-count":8,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2009,8,1]]},"published-print":{"date-parts":[[2009,8,1]]}},"URL":"https:\/\/doi.org\/10.1373\/clinchem.2009.125922","relation":{},"ISSN":["0009-9147","1530-8561"],"issn-type":[{"value":"0009-9147","type":"print"},{"value":"1530-8561","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2009,8,1]]},"published":{"date-parts":[[2009,8,1]]}}}