{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T12:12:51Z","timestamp":1770984771307,"version":"3.50.1"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100004362","name":"Schweizerische Herzstiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004362","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Prof. Dr. Max Cloetta Foundation"},{"DOI":"10.13039\/100008375","name":"Universit\u00e4t Basel","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008375","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Department of Internal Medicine at University Hospital Basel"},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["PASMP3-136995"],"award-info":[{"award-number":["PASMP3-136995"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["PP00B-102853"],"award-info":[{"award-number":["PP00B-102853"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005971","name":"Deutsche Herzstiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005971","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Brahms"},{"DOI":"10.13039\/100004337","name":"Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004337","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001316","name":"Abbott","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001316","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Nanosphere"},{"DOI":"10.13039\/501100004830","name":"Siemens","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004830","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007818","name":"Alere","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>Plaque erosion and plaque rupture occur early in the pathophysiology of acute myocardial infarction (AMI). We hypothesized that markers of plaque instability might be useful in the early diagnosis and risk stratification of AMI.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>In this multicenter study, we examined 4 markers of plaque instability, myeloperoxidase (MPO), myeloid-related protein 8\/14 (MRP-8\/14), pregnancy-associated plasma protein-A (PAPP-A), and C-reactive protein (CRP) in 398 consecutive patients presenting to the emergency department with acute chest pain and compared them to normal and high-sensitivity cardiac troponin T (cTnT and hs-cTnT). The final diagnosis was adjudicated by 2 independent cardiologists. Primary prognostic end point was death during a median follow-up of 27 months.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>The adjudicated final diagnosis was AMI in 76 patients (19%). At emergency department presentation, concentrations of all 4 biomarkers of plaque instability were significantly higher in patients with AMI than in patients with other diagnoses. However, their diagnostic accuracy as quantified by the area under the ROC curve (AUC) was low (MPO 0.63, MRP-8\/14 0.65, PAPP-A 0.62, CRP 0.59) and inferior to both normal and high-sensitivity cardiac troponin T (cTnT 0.88, hs-cTnT 0.96; P &amp;lt; 0.001 for all comparisons). Thirty-nine patients (10%) died during follow-up. Concentrations of MPO, MRP-8\/14, and CRP were higher in nonsurvivors than in survivors and predicted all-cause mortality with moderate accuracy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Biomarkers of plaque instability do not seem helpful in the early diagnosis of AMI but may provide some incremental value in the risk stratification of patients with acute chest pain.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1373\/clinchem.2011.172940","type":"journal-article","created":{"date-parts":[[2011,11,4]],"date-time":"2011-11-04T20:21:32Z","timestamp":1320438092000},"page":"246-256","source":"Crossref","is-referenced-by-count":51,"title":["Markers of Plaque Instability in the Early Diagnosis and Risk Stratification of Acute Myocardial Infarction"],"prefix":"10.1093","volume":"58","author":[{"given":"Nora","family":"Schaub","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Reichlin","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and"},{"name":"Department of Cardiology, University Hospital, Basel, Switzerland"},{"name":"Cardiovascular Division, Brigham and Women's Hospital, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"Meune","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raphael","family":"Twerenbold","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Haaf","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willibald","family":"Hochholzer","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadine","family":"Niederhauser","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piet","family":"Bosshard","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Stelzig","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Freese","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Reiter","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Gea","sequence":"first","affiliation":[{"name":"Servicio de Pneumologia, Hospital del Mar \u2013 IMIM, UPF, CIBERES, ISC III, and Servicio de Urgencias, and Hospital del Mar \u2013 IMIM, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Buser","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Mebazaa","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and"},{"name":"H\u00f4pital Lariboisi\u00e8re, APHP, University Paris 7, Inserm U942, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Osswald","sequence":"first","affiliation":[{"name":"Department of Cardiology, University Hospital, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Mueller","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and"},{"name":"Department of Cardiology, University Hospital, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2012,1,1]]},"reference":[{"key":"2020022705122475000_B1","first-page":"1","article-title":"National Hospital Ambulatory Medical Care Survey: 2005 Emergency Department Summary","volume":"386","author":"Nawar","year":"2007","journal-title":"Adv Data"},{"key":"2020022705122475000_B2","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1161\/01.CIR.101.22.2557","article-title":"Predictors of outcome in patients with acute coronary syndromes without persistent ST-segment elevation: results from an international trial of 9461 patients. 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