{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T17:30:32Z","timestamp":1768843832289,"version":"3.49.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Sixth Framework Program","award":["LSHM-CT-2004-503485"],"award-info":[{"award-number":["LSHM-CT-2004-503485"]}]},{"name":"Sixth Framework Program","award":["201668"],"award-info":[{"award-number":["201668"]}]},{"name":"European Union and BioPersMed"},{"DOI":"10.13039\/501100004956","name":"Federal Ministry of Transport, Innovation and Technology","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004956","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Federal Ministry of Economics and Labour"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,5,1]]},"abstract":"<jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>Decreased circulating 25-hydroxy-vitamin D (25-OH-vitamin D) concentrations have been associated with mortality rates, but it is unclear whether this association is causal. We performed a Mendelian randomization study and analyzed whether 3 common single-nucleotide polymorphisms (SNPs) associated with 25-OH-vitamin D concentrations are causal for mortality rates.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Genotypes of SNPs in the group-specific component gene (GC, rs2282679), 7-dehydrocholesterol reductase gene (DHCR7, rs12785878), and cytochrome P450 IIR-1 gene (CYP2R1, rs10741657) were determined in a prospective cohort study of 3316 male and female participants [mean age 62.6 (10.6) years] scheduled for coronary angiography between 1997 and 2000. 25-OH-vitamin D concentrations were determined by RIA. The main outcome measures were all-cause deaths, cardiovascular deaths, and noncardiovascular deaths.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>In a linear regression model adjusting for month of blood sampling, age, and sex, vitamin D concentrations were predicted by GC genotype (P &amp;lt; 0.001), CYP2R1 genotype (P = 0.068), and DHCR7 genotype (P &amp;lt; 0.001), with a coefficient of determination (r2) of 0.175. During a median follow-up time of 9.9 years, 955 persons (30.0%) died, including 619 deaths from cardiovascular causes. In a multivariate Cox regression adjusted for classical risk factors, GC, CYP2R1, and DHCR7 genotypes were not associated with all-cause mortality, cardiovascular mortality, or noncardiovascular mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Genetic variants associated with 25-OH-vitamin D concentrations do not predict mortality. This suggests that low 25-OH-vitamin D concentrations are associated with, but unlikely to be causal for, higher mortality rates.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1373\/clinchem.2012.193185","type":"journal-article","created":{"date-parts":[[2013,1,14]],"date-time":"2013-01-14T23:54:26Z","timestamp":1358207666000},"page":"793-797","source":"Crossref","is-referenced-by-count":39,"title":["Vitamin D and Mortality: A Mendelian Randomization Study"],"prefix":"10.1093","volume":"59","author":[{"given":"Olivia","family":"Trummer","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical University of Graz, Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Pilz","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical University of Graz, Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael M","family":"Hoffmann","sequence":"first","affiliation":[{"name":"Department of Clinical Chemistry, University Medical Center, Freiburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard R","family":"Winkelmann","sequence":"first","affiliation":[{"name":"Cardiology Group Sachsenhausen, Frankfurt-Sachsenhausen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard O","family":"Boehm","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Diabetes, Ulm University, Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Winfried","family":"M\u00e4rz","sequence":"first","affiliation":[{"name":"Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria"},{"name":"Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany"},{"name":"Synlab Academy, Synlab Services LLC, Mannheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas R","family":"Pieber","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical University of Graz, Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Obermayer-Pietsch","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical University of Graz, Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilfried","family":"Renner","sequence":"first","affiliation":[{"name":"Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, 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