{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:43:43Z","timestamp":1787165023706,"version":"build-2736575974"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,12,1]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Among the various cardiovascular diseases, heart failure (HF) is projected to have the largest increases in incidence over the coming decades; therefore, improving HF prediction is of significant value. We evaluated whether cardiac troponin T (cTnT) measured with a high-sensitivity assay and N-terminal pro\u2013B-type natriuretic peptide (NT-proBNP), biomarkers strongly associated with incident HF, improve HF risk prediction in the Atherosclerosis Risk in Communities (ARIC) study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Using sex-specific models, we added cTnT and NT-proBNP to age and race (\u201claboratory report\u201d model) and to the ARIC HF model (includes age, race, systolic blood pressure, antihypertensive medication use, current\/former smoking, diabetes, body mass index, prevalent coronary heart disease, and heart rate) in 9868 participants without prevalent HF; area under the receiver operating characteristic curve (AUC), integrated discrimination improvement, net reclassification improvement (NRI), and model fit were described.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Over a mean follow-up of 10.4 years, 970 participants developed incident HF. Adding cTnT and NT-proBNP to the ARIC HF model significantly improved all statistical parameters (AUCs increased by 0.040 and 0.057; the continuous NRIs were 50.7% and 54.7% in women and men, respectively). Interestingly, the simpler laboratory report model was statistically no different than the ARIC HF model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>cTnT and NT-proBNP have significant value in HF risk prediction. A simple sex-specific model that includes age, race, cTnT, and NT-proBNP (which can be incorporated in a laboratory report) provides a good model, whereas adding cTnT and NT-proBNP to clinical characteristics results in an excellent HF prediction model.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1373\/clinchem.2013.203638","type":"journal-article","created":{"date-parts":[[2013,9,13]],"date-time":"2013-09-13T23:33:45Z","timestamp":1379115225000},"page":"1802-1810","source":"Crossref","is-referenced-by-count":102,"title":["Troponin T and N-Terminal Pro\u2013B-Type Natriuretic Peptide: A Biomarker Approach to Predict Heart Failure Risk\u2014The Atherosclerosis Risk in Communities Study"],"prefix":"10.1093","volume":"59","author":[{"given":"Vijay","family":"Nambi","sequence":"first","affiliation":[{"name":"Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX"},{"name":"Department of Medicine, Baylor College of Medicine, Houston, TX"},{"name":"Center for Cardiovascular Disease Prevention, Methodist DeBakey Heart and Vascular Center, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxi","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Biostatistics, University of North Carolina, Chapel Hill, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lloyd E","family":"Chambless","sequence":"first","affiliation":[{"name":"Department of Biostatistics, University of North Carolina, Chapel Hill, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A","family":"de Lemos","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salim S","family":"Virani","sequence":"first","affiliation":[{"name":"Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX"},{"name":"Department of Medicine, Baylor College of Medicine, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Agarwal","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Boerwinkle","sequence":"first","affiliation":[{"name":"Human Genetics Center, University of Texas Health Science Center School of Public Health, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron C","family":"Hoogeveen","sequence":"first","affiliation":[{"name":"Department of Medicine, Baylor College of Medicine, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Aguilar","sequence":"first","affiliation":[{"name":"Department of Medicine, Baylor College of Medicine, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brad C","family":"Astor","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Wisconsin, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pothur R","family":"Srinivas","sequence":"first","affiliation":[{"name":"National Heart, Lung and Blood Institute, Bethesda, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Deswal","sequence":"first","affiliation":[{"name":"Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX"},{"name":"Department of Medicine, Baylor College of Medicine, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas H","family":"Mosley","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University of Mississippi Medical Center, Jackson, MS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Coresh","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron R","family":"Folsom","sequence":"first","affiliation":[{"name":"Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerardo","family":"Heiss","sequence":"first","affiliation":[{"name":"Department of Biostatistics, University of North Carolina, Chapel Hill, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christie M","family":"Ballantyne","sequence":"first","affiliation":[{"name":"Department of Medicine, Baylor College of Medicine, Houston, TX"},{"name":"Center for Cardiovascular Disease Prevention, Methodist DeBakey Heart and Vascular Center, Houston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,12,1]]},"reference":[{"key":"2020022705423661800_B1","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1161\/CIR.0b013e31820a55f5","article-title":"Forecasting the future of cardiovascular disease in the United States: a policy statement from the American Heart Association","volume":"123","author":"Heidenreich","year":"2011","journal-title":"Circulation"},{"key":"2020022705423661800_B2","first-page":"e2","article-title":"Heart disease and stroke statistics\u20132012 update: a report from the American Heart 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