{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:02:51Z","timestamp":1792188171217,"version":"4.4.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,11,1]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Plasma concentrations of soluble urokinase plasminogen activator receptor (suPAR) predict mortality in several clinical settings, but the long-term prognostic importance of suPAR in chest pain patients admitted on suspicion of non\u2013ST-segment elevation acute coronary syndrome (NSTEACS) is uncertain.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>suPAR concentrations were measured on admission in 449 consecutive chest pain patients in a single center between January 3, 2005, and February 14, 2006. Patients were followed for all-cause mortality from discharge until July 28, 2011.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The diagnoses at discharge comprised high-risk NSTEACS [non\u2013ST elevation myocardial infarction or unstable angina with electrocardiogram (ECG) abnormalities] in 77 patients (17.2%) and low-risk NSTEACS without evidence of myocardial ischemia in 257 (57.2%) of patients. Another 115 (25.6%) of patients received other diagnoses. During a median follow-up of 5.7 years (range, 0.01\u20136.6 years) there were 162 (36.1%) deaths. suPAR was predictive of mortality independent of age, sex, smoking, final diagnosis for the hospitalization, comorbidities (diabetes, hypertension, previous myocardial infarction, and heart failure), and variables measured on the day of admission (renal function, inflammatory markers, and markers of myocardial ischemia) with a hazard ratio (95% CI) of 1.93 (1.48\u20132.51) per SD increase in log-transformed suPAR, P &amp;lt; 0.0001. The use of suPAR improved the predictive accuracy of abnormal ECG findings and increased troponin concentrations regarding all-cause mortality (c statistics, 0.751\u20130.805; P &amp;lt; 0.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>suPAR is a strong predictor of adverse long-term outcomes and improves risk stratification beyond traditional risk variables in chest pain patients admitted with suspected NSTEACS.<\/jats:p><\/jats:sec>","DOI":"10.1373\/clinchem.2013.203778","type":"journal-article","created":{"date-parts":[[2013,7,11]],"date-time":"2013-07-11T04:52:01Z","timestamp":1373518321000},"page":"1621-1629","source":"Crossref","is-referenced-by-count":50,"title":["Soluble Urokinase Plasminogen Activator Receptor for Risk Prediction in Patients Admitted with Acute Chest Pain"],"prefix":"10.1093","volume":"59","author":[{"given":"Stig","family":"Lyngb\u00e6k","sequence":"first","affiliation":[{"name":"Copenhagen University Hospital, Glostrup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Andersson","sequence":"first","affiliation":[{"name":"Copenhagen University Hospital Gentofte, Hellerup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob L","family":"Marott","sequence":"first","affiliation":[{"name":"Copenhagen City Heart Study, Copenhagen University Hospital, Frederiksberg, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dani\u00e9l V","family":"M\u00f8ller","sequence":"first","affiliation":[{"name":"Statens Serum Institut, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Christiansen","sequence":"first","affiliation":[{"name":"Statens Serum Institut, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasper K","family":"Iversen","sequence":"first","affiliation":[{"name":"Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Clemmensen","sequence":"first","affiliation":[{"name":"Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper","family":"Eugen-Olsen","sequence":"first","affiliation":[{"name":"Clinical Research Centre, Copenhagen University Hospital, Hvidovre, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter R","family":"Hansen","sequence":"first","affiliation":[{"name":"Copenhagen University Hospital Gentofte, Hellerup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rgen L","family":"Jeppesen","sequence":"first","affiliation":[{"name":"Copenhagen University Hospital, Glostrup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,11,1]]},"reference":[{"key":"2020022705421585600_B1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/qjmed\/hcl133","article-title":"Risk prediction in patients presenting with suspected cardiac pain: the GRACE and TIMI risk scores versus clinical evaluation","volume":"100","author":"Ramsay","year":"2007","journal-title":"QJM"},{"key":"2020022705421585600_B2","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1016\/S0735-1097(00)00943-8","article-title":"Ability of troponin I to predict cardiac events in patients admitted from the emergency department","volume":"36","author":"Kontos","year":"2000","journal-title":"J Am Coll Cardiol"},{"key":"2020022705421585600_B3","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1155\/2009\/504294","article-title":"suPAR: the molecular crystal ball","volume":"27","author":"Thuno","year":"2009","journal-title":"Dis Markers"},{"key":"2020022705421585600_B4","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/j.1365-2796.2010.02252.x","article-title":"Circulating soluble urokinase plasminogen activator receptor predicts cancer, cardiovascular disease, diabetes and mortality in the general population","volume":"268","author":"Eugen-Olsen","year":"2010","journal-title":"J Intern Med"},{"key":"2020022705421585600_B5","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.atherosclerosis.2011.01.049","article-title":"Soluble urokinase plasminogen activator receptor is associated with subclinical organ damage and cardiovascular events","volume":"216","author":"Sehestedt","year":"2011","journal-title":"Atherosclerosis"},{"key":"2020022705421585600_B6","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.atherosclerosis.2011.10.039","article-title":"Soluble urokinase plasminogen activator receptor in plasma is associated with incidence of CVD. 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