{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:53:13Z","timestamp":1790250793825,"version":"4.1.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100011033","name":"Thermo Fisher Scientific","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004337","name":"Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004337","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>The release pattern of copeptin during the initial 36 h of spontaneous acute myocardial infarction (AMI) has received relatively little investigation but may provide important information on optimal timing of diagnostic measurements.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>We investigated the release pattern of copeptin and cardiac troponin T in patients with suspected acute coronary syndrome (ACS). Blood samples were collected in the ambulance, at admission, and after 2, 4, 6, and 12\u201336 h. Copeptin and high-sensitivity cardiac troponin T (hs-cTnT) were measured in heparin plasma samples.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Of 93 patients studied, 37 (39.8%) had ST-elevation myocardial infarction (STEMI), 20 (21.5%) non-STEMI, 20 (21.5%) unstable angina pectoris (UAP), and 16 (17.2%) non-ACS diagnoses. Peak copeptin concentrations were detected during ambulance transport for NSTEMI patients [median 94.0 pmol\/L, interquartile range (IQR) 53.3\u2013302.1 pmol\/L] and at admission for patients with STEMI (70.0 pmol\/L, 22.0\u2013144.8 pmol\/L). In patients with AMI, copeptin decreased significantly over time (P &amp;lt; 0.0001). This was true for patients with STEMI (P = 0.005) and non-STEMI (P = 0.021). The diagnostic performance during ambulance transport was similar for hs-cTnT (area under the ROC curve 0.75, 95% CI 0.62\u20130.88) and copeptin (0.81, 0.69\u20130.92). In early presenters (n = 52), no patient with AMI was initially (in ambulance or at admission) negative for copeptin, resulting in an area under the ROC curve of 0.963 for ambulance values and a negative predictive value of 100%. In late presenters, the negative predictive value of copeptin was 50% in ambulance and at admission.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Our analysis is the first to show a consistent early increase in copeptin at first medical contact in the ambulance and a decrease to routine values within 12\u201336 h in patients presenting early with spontaneous AMI.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1373\/clinchem.2015.240580","type":"journal-article","created":{"date-parts":[[2015,9,4]],"date-time":"2015-09-04T22:19:27Z","timestamp":1441405167000},"page":"1273-1282","source":"Crossref","is-referenced-by-count":46,"title":["Temporal Release Pattern of Copeptin and Troponin T in Patients with Suspected Acute Coronary Syndrome and Spontaneous Acute Myocardial Infarction"],"prefix":"10.1093","volume":"61","author":[{"given":"Anna","family":"Slagman","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Searle","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"M\u00fcller","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Charit\u00e9 University Hospital, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"M\u00f6ckel","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,10,1]]},"reference":[{"key":"2020022605252085100_B1","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1093\/eurheartj\/ehs184","article-title":"Third universal definition of myocardial infarction","volume":"33","author":"Thygesen","year":"2012","journal-title":"Eur Heart J"},{"key":"2020022605252085100_B2","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.1093\/eurheartj\/ehr236","article-title":"ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. The Task Force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC)","volume":"32","author":"Hamm","year":"2011","journal-title":"Eur Heart J"},{"key":"2020022605252085100_B3","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.1111\/j.1751-7133.2010.00177.x","article-title":"Copeptin: a biomarker of cardiovascular and renal function","volume":"16","author":"Morgenthaler","year":"2010","journal-title":"Congest Heart Fail"},{"key":"2020022605252085100_B4","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jacc.2009.01.076","article-title":"Incremental value of copeptin for rapid rule out of acute myocardial infarction","volume":"54","author":"Reichlin","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"2020022605252085100_B5","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1373\/clinchem.2010.161265","article-title":"Combined testing of high-sensitivity troponin T and copeptin on presentation at prespecified cutoffs improves rapid rule-out of non-ST-segment elevation myocardial infarction","volume":"57","author":"Giannitsis","year":"2011","journal-title":"Clin Chem"},{"key":"2020022605252085100_B6","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1016\/j.jacc.2010.01.029","article-title":"Copeptin improves early diagnosis of acute myocardial infarction","volume":"55","author":"Keller","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"2020022605252085100_B7","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.acvd.2010.11.002","article-title":"Combination of copeptin and high-sensitivity cardiac troponin T assay in unstable angina and non-ST-segment elevation myocardial infarction: a pilot study","volume":"104","author":"Meune","year":"2011","journal-title":"Arch Cardiovasc 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infarction: primary results of the CHOPIN trial (Copeptin Helps in the early detection Of Patients with acute myocardial INfarction)","volume":"62","author":"Maisel","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"2020022605252085100_B11","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/clc.22244","article-title":"Diagnostic performance of copeptin in patients with acute nontraumatic chest pain: BWH-TIMI ED chest pain study","volume":"37","author":"Sukul","year":"2014","journal-title":"Clin Cardiol"},{"key":"2020022605252085100_B12","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1007\/s00392-011-0343-y","article-title":"Comparison of the temporal release pattern of copeptin with conventional biomarkers in acute myocardial infarction","volume":"100","author":"Gu","year":"2011","journal-title":"Clin Res 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