{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:33:13Z","timestamp":1792715593477,"version":"4.5.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KFO252"],"award-info":[{"award-number":["KFO252"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["LE3660\/1-2"],"award-info":[{"award-number":["LE3660\/1-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Union Horizon 2020 Program","award":["ENS@T-HT - #633983-2"],"award-info":[{"award-number":["ENS@T-HT - #633983-2"]}]},{"DOI":"10.13039\/501100003042","name":"Else Kr\u00f6ner-Promotionskolleg or Else Kr\u00f6ner-Fresenius-Stiftung","doi-asserted-by":"publisher","award":["2013_A182"],"award-info":[{"award-number":["2013_A182"]}],"id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KFO252"],"award-info":[{"award-number":["KFO252"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["LE3660\/1-2"],"award-info":[{"award-number":["LE3660\/1-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ZonMW","award":["171002102"],"award-info":[{"award-number":["171002102"]}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["RE752\/20\u20131"],"award-info":[{"award-number":["RE752\/20\u20131"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KFO252"],"award-info":[{"award-number":["KFO252"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["LE3660\/1-2"],"award-info":[{"award-number":["LE3660\/1-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>Differentiating patients with primary aldosteronism caused by aldosterone-producing adenomas (APAs) from those with bilateral adrenal hyperplasia (BAH), which is essential for choice of therapeutic intervention, relies on adrenal venous sampling (AVS)-based measurements of aldosterone and cortisol. We assessed the utility of LC-MS\/MS\u2013based steroid profiling to stratify patients with primary aldosteronism.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Fifteen adrenal steroids were measured by LC-MS\/MS in peripheral and adrenal venous plasma from AVS studies for 216 patients with primary aldosteronism at 3 tertiary referral centers. Ninety patients were diagnosed with BAH and 126 with APAs on the basis of immunoassay-derived adrenal venous aldosterone lateralization ratios.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Among 119 patients confirmed to have APAs at follow-up, LC-MS\/MS\u2013derived lateralization ratios of aldosterone normalized to cortisol, dehydroepiandrosterone, and androstenedione were all higher (P &amp;lt; 0.0001) than immunoassay-derived ratios. The hybrid steroids, 18-oxocortisol and 18-hydroxycortisol, also showed lateralized secretion in 76% and 35% of patients with APAs. Adrenal venous concentrations of glucocorticoids and androgens were bilaterally higher in patients with BAH than in those with APAs. Consequently, peripheral plasma concentrations of 18-oxocortisol were 8.5-fold higher, whereas concentrations of cortisol, corticosterone, and dehydroepiandrosterone were lower in patients with APAs than in those with BAH. Correct classification of 80% of cases of APAs vs BAH was thereby possible by use of a combination of steroids in peripheral plasma.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>LC-MS\/MS\u2013based steroid profiling during AVS achieves higher aldosterone lateralization ratios in patients with APAs than immunoassay. LC-MS\/MS also enables multiple measures for discriminating unilateral from bilateral aldosterone excess, with potential use of peripheral plasma for subtype classification.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1373\/clinchem.2015.251199","type":"journal-article","created":{"date-parts":[[2016,1,19]],"date-time":"2016-01-19T23:44:09Z","timestamp":1453247049000},"page":"514-524","source":"Crossref","is-referenced-by-count":146,"title":["Mass Spectrometry\u2013Based Adrenal and Peripheral Venous Steroid Profiling for Subtyping Primary Aldosteronism"],"prefix":"10.1093","volume":"62","author":[{"given":"Graeme","family":"Eisenhofer","sequence":"first","affiliation":[{"name":"Institute of Clinical Chemistry and Laboratory Medicine and"},{"name":"Department of Internal Medicine III, Technische Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Dekkers","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirko","family":"Peitzsch","sequence":"first","affiliation":[{"name":"Institute of Clinical Chemistry and Laboratory Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna S","family":"Dietz","sequence":"first","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Bidlingmaier","sequence":"first","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Treitl","sequence":"first","affiliation":[{"name":"Klinische Radiologie, Klinikum der Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy A","family":"Williams","sequence":"first","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV and"},{"name":"Division of Internal Medicine and Hypertension, Department of Medical Sciences, University of Turin, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan R","family":"Bornstein","sequence":"first","affiliation":[{"name":"Department of Internal Medicine III, Technische Universit\u00e4t Dresden, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Haase","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Diabetes, and Metabolism and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L C","family":"Rump","sequence":"first","affiliation":[{"name":"Department of Nephrology, University Dusseldorf, Medical Faculty, Dusseldorf, Germany; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger 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