{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T15:50:30Z","timestamp":1772812230294,"version":"3.50.1"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"K.G. Jebsen Foundation"},{"DOI":"10.13039\/501100004056","name":"Akershus University College of Applied Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004056","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>We examined whether secretoneurin (SN), a biomarker associated with cardiomyocyte Ca2+ handling, provides prognostic information in patients with acute respiratory failure (ARF).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>We included 490 patients with ARF, defined as ventilatory support &amp;gt;6 h, with blood samples available on admission to the intensive care unit (ICU). SN concentrations were measured by RIA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>A total of 209 patients (43%) were hospitalized with cardiovascular (CV)-related ARF, and 90-day mortality rates were comparable between CV- and non\u2013CV-related ARF (n = 281): 31% vs 24%, P = 0.11. Admission SN concentrations were higher in nonsurvivors than in survivors in both CV-related (median 148 [quartile 1\u20133, 117\u2013203] vs 108 [87\u2013143] pmol\/L, P &amp;lt; 0.001) and non\u2013CV-related ARF (139 [115\u2013184] vs 113 [91\u2013139] pmol\/L, P &amp;lt; 0.001). In patients with CV-related ARF, SN concentrations on ICU admission were associated with 90-day mortality [odds ratio (OR) 1.97 (95% CI, 1.04\u20133.73, P = 0.04)] after adjusting for established risk indices, including N-terminal-pro-B-type natriuretic peptide (NT-proBNP) concentrations. SN also improved patient classification in CV-related ARF as assessed by the net reclassification index: 0.32 (95% CI, 0.04\u20130.59), P = 0.03. The area under the curve (AUC) of SN to predict mortality in patients with CV-related ARF was 0.72 (95% CI, 0.65\u20130.79), and the AUC of NT-proBNP was 0.64 (0.56\u20130.73). In contrast, SN concentrations on ICU admission did not provide incremental prognostic value to established risk indices in patients with non\u2013CV-related ARF, and the AUC was 0.67 (0.60\u20130.75).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>SN concentrations measured on ICU admission provided incremental prognostic information to established risk indices in patients with CV-related ARF, but not in patients with non\u2013CV-related ARF.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1373\/clinchem.2016.258764","type":"journal-article","created":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T23:09:12Z","timestamp":1471561752000},"page":"1380-1389","source":"Crossref","is-referenced-by-count":17,"title":["Prognostic Value of Secretoneurin in Patients with Acute Respiratory Failure: Data from the FINNALI Study"],"prefix":"10.1093","volume":"62","author":[{"given":"Peder L","family":"Myhre","sequence":"first","affiliation":[{"name":"Division of Medicine, Akershus University Hospital, L\u00f8renskog, Norway and Center for Heart Failure Research, University of Oslo, Oslo, Norway"},{"name":"Center for Clinical Heart Research, Oslo University Hospital Ullev\u00e5l, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anett H","family":"Ottesen","sequence":"first","affiliation":[{"name":"Division of Medicine, Akershus University Hospital, L\u00f8renskog, Norway and Center for Heart Failure Research, University of Oslo, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marjatta","family":"Okkonen","sequence":"first","affiliation":[{"name":"Division of Intensive Care Medicine, Department of Anesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Linko","sequence":"first","affiliation":[{"name":"Division of Intensive Care Medicine, Department of Anesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mats","family":"Stridsberg","sequence":"first","affiliation":[{"name":"Department of Medical Sciences, Uppsala University, Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e5le","family":"Nyg\u00e5rd","sequence":"first","affiliation":[{"name":"Bioinformatics Core Facility, Oslo University Hospital and the University of Oslo, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geir","family":"Christensen","sequence":"first","affiliation":[{"name":"Institute for Experimental Medical Research, Oslo University Hospital, Ullev\u00e5l, Oslo, Norway and Center for Heart Failure Research, University of Oslo, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ville","family":"Pettil\u00e4","sequence":"first","affiliation":[{"name":"Division of Intensive Care Medicine, Department of Anesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland"},{"name":"Department of Intensive Care Medicine, Bern University Hospital, University of Bern, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torbj\u00f8rn","family":"Omland","sequence":"first","affiliation":[{"name":"Division of Medicine, Akershus University Hospital, L\u00f8renskog, Norway and Center for Heart Failure Research, University of Oslo, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helge","family":"R\u00f8sj\u00f8","sequence":"first","affiliation":[{"name":"Division of Medicine, Akershus University Hospital, L\u00f8renskog, 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