{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T15:47:47Z","timestamp":1772812067744,"version":"3.50.1"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>Cardiac troponin T concentrations measured with high-sensitivity assays (hs-cTnT) provide important prognostic information for patients with stable coronary artery disease (CAD). However, whether hs-cTnT concentrations mainly reflect left ventricular (LV) remodeling or recurrent myocardial ischemia in this population is not known.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>We measured hs-cTnT concentrations in 619 subjects with suspected stable CAD in a prospectively designed multicenter study. We identified associations with indices of LV remodeling, as assessed by cardiac MRI and echocardiography, and evidence of myocardial ischemia diagnosed by single positron emission computed tomography.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Median hs-cTnT concentration was 7.8 ng\/L (interquartile range, 4.8\u201311.6 ng\/L), and 111 patients (18%) had hs-cTnT concentrations above the upper reference limit (&amp;gt;14 ng\/L). Patients with hs-cTnT &amp;gt;14 ng\/L had increased LV mass (144 \u00b1 40 g vs 116 \u00b1 34 g; P &amp;lt; 0.001) and volume (179 \u00b1 80 mL vs 158 \u00b1 44 mL; P = 0.006), lower LV ejection fraction (LVEF) (59 \u00b1 14 vs 62 \u00b1 11; P = 0.006) and global longitudinal strain (14.1 \u00b1 3.4% vs 16.9 \u00b1 3.2%; P &amp;lt; 0.001), and more reversible perfusion defects (P = 0.001) and reversible wall motion abnormalities (P = 0.008). Age (P = 0.009), estimated glomerular filtration rate (P = 0.01), LV mass (P = 0.003), LVEF (P = 0.03), and evidence of reversible myocardial ischemia (P = 0.004 for perfusion defects and P = 0.02 for LV wall motion) were all associated with increasing hs-cTnT concentrations in multivariate analysis. We found analogous results when using the revised US upper reference limit of 19 ng\/L.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>hs-cTnT concentrations reflect both LV mass and reversible myocardial ischemia in patients with suspected stable CAD.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1373\/clinchem.2018.288894","type":"journal-article","created":{"date-parts":[[2018,6,29]],"date-time":"2018-06-29T14:34:57Z","timestamp":1530282897000},"page":"1370-1379","source":"Crossref","is-referenced-by-count":17,"title":["Cardiac Troponin T Concentrations, Reversible Myocardial Ischemia, and Indices of Left Ventricular Remodeling in Patients with Suspected Stable Angina Pectoris: a DOPPLER-CIP Substudy"],"prefix":"10.1093","volume":"64","author":[{"given":"Peder L","family":"Myhre","sequence":"first","affiliation":[{"name":"Division of Medicine, Akershus University Hospital, L\u00f8renskog, Norway and Center for Heart Failure Research, University of Oslo, Oslo, Norway"},{"name":"Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torbj\u00f8rn","family":"Omland","sequence":"first","affiliation":[{"name":"Division of Medicine, Akershus University Hospital, L\u00f8renskog, Norway and Center for Heart Failure Research, University of Oslo, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian I","family":"Sarvari","sequence":"first","affiliation":[{"name":"Department of Cardiology, Oslo University Hospital, Rikshospitalet and Center for Heart Failure Research, University of Oslo, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heikki","family":"Ukkonen","sequence":"first","affiliation":[{"name":"Department of Medicine, Turku University Hospital, Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Rademakers","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Sciences, University Hospitals Leuven and KU Leuven, Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan E","family":"Engvall","sequence":"first","affiliation":[{"name":"Department of Clinical Physiology Link\u00f6ping University, Link\u00f6ping, Sweden and Center for Medical Image Science and Visualization (CMIV), Link\u00f6ping University, Link\u00f6ping, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tor-Arne","family":"Hagve","sequence":"first","affiliation":[{"name":"Division of Diagnostics and Technology, Akershus University Hospital, L\u00f8renskog and Institute of Clinical Medicine, University of Oslo, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eike","family":"Nagel","sequence":"first","affiliation":[{"name":"Kings College Hospital, Department of Non-invasive Cardiology, Denmark Hill, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Sicari","sequence":"first","affiliation":[{"name":"CNR, Istituto di Fisiologia Clinica, Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose L","family":"Zamorano","sequence":"first","affiliation":[{"name":"Hospital Universitario Ram\u00f3n y Cajal, Cardiovascular Imaging Unit, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Monaghan","sequence":"first","affiliation":[{"name":"Kings College Hospital, Department of Non-invasive Cardiology, Denmark Hill, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"D'hooge","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Sciences, University Hospitals Leuven and KU Leuven, Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thor","family":"Edvardsen","sequence":"first","affiliation":[{"name":"Department of Cardiology, Oslo University Hospital, Rikshospitalet and Center for Heart Failure Research, University of Oslo, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of the DOPPLER-CIP Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helge","family":"R\u00f8sj\u00f8","sequence":"additional","affiliation":[{"name":"Division of Medicine, Akershus University Hospital, L\u00f8renskog, Norway and Center for Heart Failure Research, University of Oslo, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,9,1]]},"reference":[{"key":"2020022606070102700_B1","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/0735-1097(90)90201-Y","article-title":"Mode of death, 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