{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T14:28:00Z","timestamp":1648823280122},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Deficiency of 25-hydroxyvitamin D in serum is endemic in the general population, and testing for this hormone is useful in accessing a patient's overall health and well-being.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We obtained blood from 216 hospitalized patients and outpatients divided into 4 groups thought to be at high risk of 25-hydroxyvitamin D deficiency: homeless, recreational drug abusers, psychiatric patients with limited access to the outdoors, and those infected with HIV. The 25-hydroxyvitamin D concentrations from these patients were determined with 2 different methodologies (immunoassay and mass spectrometry) and compared against 25-hydroxyvitamin D concentrations in apparently healthy controls. We hypothesized that these groups may be at higher risk for vitamin D deficiency because of poor nutrition, inadequate housing, restricted access to outdoors, or the presence of chronic disease.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>For each of the patient groups including healthy controls, the median concentration of 25-hydroxyvitamin D was below 30 ng\/mL, indicating deficiency. Comparisons between the healthy controls and the other groups were not statistically significant with either methodology, except for the homeless patients in whom a higher number of individuals had 25-hydroxyvitamin D concentrations below 20 ng\/mL. Results between the 2 testing platforms demonstrated that only 52% of the specimens analyzed by immunoassay agreed within \u00b110% of the LC-MS\/MS results, with an overall correlation coefficient to 0.920. The degree of concordance for deficiency with 2 published cutoffs of 20 and 30 ng\/mL was 91% and 91%, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Vitamin D deficiency is a common finding in all the populations studied. The Lumipulse\u00ae G vitamin D immunoassay is an alternative for detecting vitamin D deficiency.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1373\/jalm.2018.028316","type":"journal-article","created":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T22:44:12Z","timestamp":1555541052000},"page":"61-68","source":"Crossref","is-referenced-by-count":0,"title":["Serum 25-Hydroxyvitamin D Concentrations from Patient Groups at High Risk for Deficiency"],"prefix":"10.1093","volume":"4","author":[{"given":"Alan H B","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohit","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chui","family":"Mei Ong","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah","family":"French","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,7,1]]},"reference":[{"key":"2022020118554039200_B1","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1056\/NEJMra070553","article-title":"Vitamin D deficiency","volume":"357","author":"Holick","year":"2007","journal-title":"N Engl J Med"},{"key":"2022020118554039200_B2","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1093\/ajcn\/84.1.18","article-title":"Estimation of optimal concentrations of 25-hydroxyvitamin D for multiple health outcomes","volume":"84","author":"Bischoff-Ferrari","year":"2006","journal-title":"Am J Clin Nutr"},{"key":"2022020118554039200_B3","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1210\/jc.2011-0385","article-title":"Evaluation, treatment and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline","volume":"96","author":"Holick","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"2022020118554039200_B4","volume-title":"Institute of Medicine (US) Committee to Review Dietary Reference Intakes for Calcium and Vitamin D","author":"Ross","year":"2011"},{"key":"2022020118554039200_B5","doi-asserted-by":"crossref","first-page":"g2035","DOI":"10.1136\/bmj.g2035","article-title":"Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analysis of observational studies and randomized trials","volume":"348","author":"Theodoratou","year":"2014","journal-title":"BMJ"},{"key":"2022020118554039200_B6","unstructured":"Centers for Disease Control. CDC second national report on biochemical indicators of diet and nutrition in the U.S. population 2012. https:\/\/www.cdc.gov\/nutritionreport\/pdf\/Nutrition_Book_complete508_final.pdf (Accessed September 2018). p. 175."},{"key":"2022020118554039200_B7","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1365-2265.2011.04320.x","article-title":"Prevalence of vitamin D deficiency and its determinants in Australian adults aged 25 years and older: a national, population-based study","volume":"77","author":"Daly","year":"2012","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2022020118554039200_B8","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.cca.2010.10.013","article-title":"Vitamin D status of county hospital patients assessed by the DiaSorin LIAISON\u00ae 25-hydroxyvitamin D assay","volume":"412","author":"French","year":"2011","journal-title":"Clin Chim Acta"},{"key":"2022020118554039200_B9","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1002\/ajhb.20780","article-title":"Dietary intake, overweight status, and perceptions of food insecurity among homeless Minnesotan youth","volume":"20","author":"Smith","year":"2008","journal-title":"Am J Hum Biol"},{"key":"2022020118554039200_B10","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.ecl.2014.05.005","article-title":"Vitamin D and calcium abnormalities in the HIV-infected population","volume":"43","author":"Escota","year":"2014","journal-title":"Endocrinol Metab Clin North Am"},{"key":"2022020118554039200_B11","unstructured":"Department of Health and Human Services. Office of Inspector General. Medicare payments for clinical laboratory tests in s2016: baseline data. https:\/\/oig.hhs.gov\/oei\/reports\/oei-09-17-00140.pdf (Accessed August 2018)."},{"key":"2022020118554039200_B12","article-title":"VITD-B 2017 College of American Pathologists proficiency testing survey","author":"College of American Pathologists","year":"2017"},{"key":"2022020118554039200_B13","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.cca.2012.10.026","article-title":"Implementation of liquid chromatography\/mass spectrometry into the clinical laboratory","volume":"420","author":"Wu","year":"2013","journal-title":"Clin Chim Acta"},{"key":"2022020118554039200_B14","article-title":"Fujirebio US, Inc. Lumipulse\u00ae G 25OH Vitamin D package insert"},{"key":"2022020118554039200_B15","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1097\/QAI.0b013e31821ae418","article-title":"Vitamin D deficiency in HIV infected and un-infected women in the US","volume":"57","author":"Adeyemi","year":"2011","journal-title":"J Acquir Immune Defic Syndr"},{"key":"2022020118554039200_B16","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1097\/QAD.0b013e32833c3281","article-title":"Efavirenz is associated with severe vitamin D deficiency and increased alkaline phosphatase","volume":"24","author":"Welz","year":"2010","journal-title":"AIDS"},{"key":"2022020118554039200_B17","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/j.mehy.2007.04.001","article-title":"Vitamin D deficiency may play a role in depression","volume":"69","author":"Berk","year":"2007","journal-title":"Med Hypotheses"},{"key":"2022020118554039200_B18","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.schres.2013.08.036","article-title":"Vitamin D deficiency in first episode psychosis: a case-control study","volume":"150","author":"Crews","year":"2013","journal-title":"Schizophr Res"},{"key":"2022020118554039200_B19","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ijcard.2011.01.032","article-title":"Vitamin D deficiency is associated with significant coronary stenoses in asymptomatic African American chronic cocaine users","volume":"158","author":"Lai","year":"2012","journal-title":"Int J Cardiol"},{"key":"2022020118554039200_B20","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.3390\/nu4081076","article-title":"Vitamin D and calcium status in South African adolescents with alcohol use disorders","volume":"4","author":"Naude","year":"2012","journal-title":"Nutrients"},{"key":"2022020118554039200_B21","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1017\/S0007114511007409","article-title":"Determinants of plasma 25-hydroxyvitamin D and development of prediction models in three US cohorts","volume":"108","author":"Bertrand","year":"2012","journal-title":"Br J Nutr"},{"key":"2022020118554039200_B22","unstructured":"National Institutes of Health. Vitamin D: fact sheet for health professionals. https:\/\/ods.od.nih.gov\/factsheets\/VitaminD-HealthProfessional\/#h3 (Accessed September 2018)."},{"key":"2022020118554039200_B23","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1079\/PHN200053","article-title":"Dietary inadequacies observed in homeless men visiting an emergency night shelter in Paris","volume":"4","author":"Darmon","year":"2001","journal-title":"Public Health Nutr"},{"key":"2022020118554039200_B24","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1373\/jalm.2017.023051","article-title":"The (sun)light and dark of 25-hydroxyvitamin D testing","volume":"3","author":"French","year":"2018","journal-title":"J Appl Lab Med"}],"container-title":["The Journal of Applied Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jalm\/article-pdf\/4\/1\/61\/42354069\/4_4_1_61.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jalm\/article-pdf\/4\/1\/61\/42354069\/4_4_1_61.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T19:08:24Z","timestamp":1643742504000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jalm\/article\/4\/1\/61\/5603077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,1]]},"references-count":24,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,7,1]]},"published-print":{"date-parts":[[2019,7,1]]}},"URL":"https:\/\/doi.org\/10.1373\/jalm.2018.028316","relation":{},"ISSN":["2576-9456","2475-7241"],"issn-type":[{"value":"2576-9456","type":"print"},{"value":"2475-7241","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,7,1]]},"published":{"date-parts":[[2019,7,1]]}}}