{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T09:57:49Z","timestamp":1775210269823,"version":"3.50.1"},"reference-count":15,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2012,2,21]],"date-time":"2012-02-21T00:00:00Z","timestamp":1329782400000},"content-version":"unspecified","delay-in-days":1481,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Twin Res Hum Genet"],"published-print":{"date-parts":[[2008,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We test the hypothesis that parents who conceived twins by assisted reproduction technology (ART), but experienced loss of one twin, have a different parental\u2013child relationship compared with ART parents following a singleton pregnancy. We used the 1994\u20132005 ART database of the Centre for Infertility of the Arcispedale Santa Maria Nuova in Reggio Emilia, Italy to identify families of 53 singleton births after the \u2018vanishing\u2019 twin syndrome. The controls comprised 106 families who conceived and delivered singletons, matched for gestational age (\u2265 28 \u2264 31, \u2265 32 \u2264 36, \u2265 37 weeks), maternal age (&lt; 35, \u2265 35 \u2264 40, &gt; 40 years), child's age (1\u20133, 4\u20136, and 7\u201311 years) and child's gender. We completed 3 tests: a sociodemographic questionnaire, the QUIT \u2014 Italian Questionnaires of Temperament \u2014 motor scale, and the Child Vulnerability Scale. We found that children in the study had significantly more difficulties at the beginning of nursery school (<jats:italic>p<\/jats:italic>= .002) and kindergarten (<jats:italic>p<\/jats:italic>= .0005), with more frequent anxiety of separation from the parents (nursery school,<jats:italic>p<\/jats:italic>= .009; kindergarten,<jats:italic>p<\/jats:italic>= .001). We found a lower mean QUIT motor score for the 7- to 11-year-old children when compared to the general Italian normative values, suggesting that parents perceived their children as having more motor difficulties. In contrast, analysis of the Child Vulnerability Scale showed that significantly more parents (15.1%) from the controls perceived their child as vulnerable compared to those from the study group (3.8%),<jats:italic>p<\/jats:italic>= .034. We conclude that despite the perceived motor difficulties and the difficulties in the process of individuation\u2013separation that appear at the beginning of the different educational circumstances, parents of singletons following the \u2018vanishing\u2019 twin syndrome perceive their children as \u2018invincible\u2019, and thus less vulnerable compared to controls.<\/jats:p>","DOI":"10.1375\/twin.11.1.93","type":"journal-article","created":{"date-parts":[[2008,2,5]],"date-time":"2008-02-05T15:47:22Z","timestamp":1202226442000},"page":"93-98","source":"Crossref","is-referenced-by-count":5,"title":["Psychological Vulnerability of Singleton Children After the \u2018Vanishing\u2019 of a Co-Twin Following Assisted Reproduction"],"prefix":"10.1017","volume":"11","author":[{"given":"Leonardo","family":"De Pascalis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiorella","family":"Monti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Agostini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piergiuseppina","family":"Fagandini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni B.","family":"La Sala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isaac","family":"Blickstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2012,2,21]]},"reference":[{"key":"p_1_279","doi-asserted-by":"publisher","DOI":"10.1375\/twin.10.1.202"},{"key":"p_2_280","unstructured":"Axia, G. (2002 ). QUIT: questionari italiani del temperamento. Trento: Erikson."},{"key":"p_3_281","first-page":"13","volume":"49","author":"Baor L","year":"2004","journal-title":"International Journal of Fertility and Womens Medicine"},{"key":"p_4_282","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2004.10.007"},{"key":"p_5_283","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1111\/j.1469-8749.1998.tb15390.x","volume":"40","author":"Blickstein I.","year":"1998","journal-title":"Developmental Medicine and Child Neurology"},{"key":"p_6_284","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/21.1.89"},{"key":"p_7_285","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0002-7138(09)61442-4","volume":"14","author":"Fraiberg S.","year":"1975","journal-title":"Journal of the American Academy of Child Psychiatry"},{"key":"p_8_286","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1017\/S0001566000008278","volume":"1","author":"Landy H. J.","year":"1982","journal-title":"Acta Geneticae Medicae et Gemellologiae"},{"key":"p_9_287","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/4.2.177"},{"key":"p_10_288","first-page":"113","volume":"49","author":"La Sala G. B.","year":"2004","journal-title":"International Journal of Fertility and Womens Medicine"},{"key":"p_11_289","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2005.11.073"},{"key":"p_12_290","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1542\/peds.83.1.26","volume":"83","author":"Perrin E. C.","year":"1989","journal-title":"Pediatrics"},{"key":"p_13_291","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/j.1469-8749.1997.tb07434.x","volume":"39","author":"Pharoah P. O.","year":"1997","journal-title":"Developmental Medicine and Child Neurology"},{"key":"p_14_292","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dei142"},{"key":"p_15_293","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem225"}],"container-title":["Twin Research and Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S183242740000880X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T23:07:37Z","timestamp":1708556857000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S183242740000880X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,2,1]]}},"alternative-id":["S183242740000880X"],"URL":"https:\/\/doi.org\/10.1375\/twin.11.1.93","relation":{},"ISSN":["1832-4274","1839-2628"],"issn-type":[{"value":"1832-4274","type":"print"},{"value":"1839-2628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,2,1]]}}}