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We hypothesized that common single nucleotide polymorphisms (SNPs) in the <jats:italic>FGF2<\/jats:italic> gene may alter angiogenic potential and thereby susceptibility to ovarian cancer. We analyzed 25 <jats:italic>FGF2<\/jats:italic> tgSNPs using five independent study populations from the United States and Australia. Analysis was restricted to non-Hispanic White women with serous ovarian carcinoma (1269 cases and 2829 controls). There were no statistically significant associations between any <jats:italic>FGF2<\/jats:italic> SNPs and ovarian cancer risk. There were two nominally statistically significant associations between heterozygosity for two <jats:italic>FGF2<\/jats:italic> SNPs (rs308379 and rs308447; <jats:italic>p<\/jats:italic> &lt; .05) and serous ovarian cancer risk in the combined dataset, but rare homozygous estimates did not achieve statistical significance, nor were they consistent with the log additive model of inheritance. Overall genetic variation in <jats:italic>FGF2<\/jats:italic> does not appear to play a role in susceptibility to ovarian cancer.<\/jats:p>","DOI":"10.1375\/twin.12.3.269","type":"journal-article","created":{"date-parts":[[2009,5,20]],"date-time":"2009-05-20T15:01:51Z","timestamp":1242831711000},"page":"269-275","source":"Crossref","is-referenced-by-count":8,"title":["Polymorphisms in the <i>FGF2<\/i> Gene and Risk of Serous Ovarian Cancer: Results From the Ovarian Cancer Association Consortium"],"prefix":"10.1017","volume":"12","author":[{"given":"Sharon E.","family":"Johnatty","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Beesley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda B.","family":"Spurdle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"DeFazio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Penelope M.","family":"Webb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Australian Ovarian Cancer Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Australian Cancer Study (Ovarian Cancer)","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen L.","family":"Goode","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David N.","family":"Rider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A.","family":"Vierkant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna H.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malcolm","family":"Pike","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Van Den Berg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten","family":"Moysich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Ness","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Doherty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary-Anne","family":"Rossing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celeste Leigh","family":"Pearce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgia","family":"Chenevix-Trench","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2012,2,21]]},"reference":[{"key":"p_1_351","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600625"},{"key":"p_2_352","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bth457"},{"key":"p_3_353","doi-asserted-by":"publisher","DOI":"10.1210\/er.18.1.26"},{"key":"p_4_354","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1996.4572"},{"key":"p_5_355","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199311183292108"},{"key":"p_6_356","doi-asserted-by":"publisher","DOI":"10.1086\/381000"},{"key":"p_7_357","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1994.1290"},{"key":"p_8_358","doi-asserted-by":"publisher","DOI":"10.1038\/ng1669"},{"key":"p_9_359","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207979"},{"key":"p_10_360","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(00)00457-X"},{"key":"p_11_361","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-9-174"},{"key":"p_12_362","doi-asserted-by":"publisher","DOI":"10.1126\/science.2432664"},{"key":"p_13_363","first-page":"4513","volume":"60","author":"Gayther S. 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