{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T07:15:37Z","timestamp":1776323737815,"version":"3.50.1"},"reference-count":29,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chest"],"published-print":{"date-parts":[[2007,6]]},"DOI":"10.1378\/chest.06-2264","type":"journal-article","created":{"date-parts":[[2007,3,30]],"date-time":"2007-03-30T20:46:07Z","timestamp":1175287567000},"page":"1666-1671","source":"Crossref","is-referenced-by-count":71,"title":["High Prevalence of Proximal and Distal Gastroesophageal Reflux Disease in Advanced COPD"],"prefix":"10.1016","volume":"131","author":[{"given":"Robert R.","family":"Kempainen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kay","family":"Savik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy P.","family":"Whelan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordan M.","family":"Dunitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia S.","family":"Herrington","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne L.","family":"Billings","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1378\/chest.06-2264_bib1","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/0016-5085(90)90945-W","article-title":"Most asthmatics have gastroesophageal reflux with or without bronchodilator therapy","volume":"99","author":"Sontag","year":"1990","journal-title":"Gastroenterology"},{"key":"10.1378\/chest.06-2264_bib2","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1183\/09031936.06.00037005","article-title":"High prevalence of abnormal acid gastro-oesophageal reflux in idiopathic pulmonary fibrosis","volume":"27","author":"Raghu","year":"2006","journal-title":"Eur Respir J"},{"key":"10.1378\/chest.06-2264_bib3","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1016\/j.healun.2004.11.312","article-title":"Gastroesophageal reflux (symptomatic and silent): a potentially significant problem in patients with cystic fibrosis before and after lung transplantation","volume":"24","author":"Button","year":"2005","journal-title":"J Heart Lung Transplant"},{"key":"10.1378\/chest.06-2264_bib4","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0002-9343(97)89514-9","article-title":"Asthma and gastroesophageal reflux: acid suppressive therapy improves asthma outcome","volume":"100","author":"Harding","year":"1996","journal-title":"Am J Med"},{"key":"10.1378\/chest.06-2264_bib5","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1378\/chest.128.3.1128","article-title":"Effects of 24 weeks of lansoprazole therapy on asthma symptoms, exacerbations, quality of life, and pulmonary function in adult asthmatic patients with acid reflux symptoms","volume":"128","author":"Littner","year":"2005","journal-title":"Chest"},{"key":"10.1378\/chest.06-2264_bib6","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1164\/rccm.200507-1167OC","article-title":"Effects of esomeprazole 40 mg twice daily on asthma","volume":"173","author":"Kiljander","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.06-2264_bib7","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1378\/chest.129.3.794","article-title":"Sole treatment of acid gastroesophageal reflux in idiopathic pulmonary fibrosis: a case series","volume":"129","author":"Raghu","year":"2006","journal-title":"Chest"},{"key":"10.1378\/chest.06-2264_bib8","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.jtcvs.2005.10.014","article-title":"Laparoscopic fundoplication in patients with end-stage lung disease awaiting transplantation","volume":"131","author":"Linden","year":"2006","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1378\/chest.06-2264_bib9","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1067\/mtc.2003.166","article-title":"Improved lung allograft function after fundoplication in patients with gastroesophageal reflux disease undergoing lung transplantation","volume":"125","author":"Davis","year":"2003","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1378\/chest.06-2264_bib10","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1378\/chest.120.4.1184","article-title":"The effects of an inhaled \u03b22-adrenergic agonist on lower esophageal function","volume":"120","author":"Crowell","year":"2001","journal-title":"Chest"},{"key":"10.1378\/chest.06-2264_bib11","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1378\/chest.119.4.1043","article-title":"Increased prevalence of gastroesophageal reflux symptoms in patients with COPD","volume":"119","author":"Mokhlesi","year":"2001","journal-title":"Chest"},{"key":"10.1378\/chest.06-2264_bib12","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1164\/ajrccm.162.1.9907072","article-title":"The prevalence of gastroesophageal reflux in asthma patients without reflux symptoms","volume":"162","author":"Harding","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.06-2264_bib13","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1183\/09031936.04.00107004","article-title":"Increased gastro-oesophageal reflux disease in patients with severe COPD","volume":"23","author":"Casanova","year":"2004","journal-title":"Eur Respir J"},{"key":"10.1378\/chest.06-2264_bib14","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1378\/chest.101.6.1521","article-title":"Esophageal function and gastroesophageal reflux during sleep and waking in patients with chronic obstructive pulmonary disease","volume":"101","author":"Orr","year":"1992","journal-title":"Chest"},{"key":"10.1378\/chest.06-2264_bib15","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.athoracsur.2005.03.106","article-title":"Prevalence of gastroesophageal reflux in end- stage lung disease candidates for lung transplant","volume":"80","author":"D'Ovidio","year":"2005","journal-title":"Ann Thorac Surg"},{"key":"10.1378\/chest.06-2264_bib16","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/BF01296157","article-title":"Esophageal manometry in 95 healthy adult volunteers: variability of pressures with age and frequency of \u201cabnormal\u201d contractions","volume":"32","author":"Richter","year":"1987","journal-title":"Dig Dis Sci"},{"key":"10.1378\/chest.06-2264_bib17","doi-asserted-by":"crossref","first-page":"130S","DOI":"10.1016\/S0002-9343(97)00338-0","article-title":"Ambulatory esophageal pH monitoring","volume":"103","author":"Richter","year":"1997","journal-title":"Am J Med"},{"key":"10.1378\/chest.06-2264_bib18","first-page":"G357","article-title":"Spatiotemporal characteristics of physiological gastroesophageal reflux","volume":"266","author":"Weusten","year":"1994","journal-title":"Am J Physiol"},{"key":"10.1378\/chest.06-2264_bib19","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1136\/gut.2004.051821","article-title":"Epidemiology of gastro-oesophageal reflux disease: a systematic review","volume":"54","author":"Dent","year":"2005","journal-title":"Gut"},{"key":"10.1378\/chest.06-2264_bib20","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1056\/NEJM199903183401101","article-title":"Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma","volume":"340","author":"Lagergren","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.06-2264_bib21","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/BF02090218","article-title":"Barrett's esophagus and other mucosal evidence of reflux in asymptomatic subjects with abnormal 24-hour esophageal pH monitoring","volume":"39","author":"Fass","year":"1994","journal-title":"Dig Dis Sci"},{"key":"10.1378\/chest.06-2264_bib22","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1111\/j.1572-0241.2004.40626.x","article-title":"Characteristics and clinical relevance of proximal esophageal pH monitoring","volume":"99","author":"Cool","year":"2004","journal-title":"Am J Gastroenterol"},{"key":"10.1378\/chest.06-2264_bib23","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1023\/A:1018802330957","article-title":"Dual-channel ambulatory esophageal pH monitoring: a useful diagnostic tool?","volume":"42","author":"Wo","year":"1997","journal-title":"Dig Dis Sci"},{"key":"10.1378\/chest.06-2264_bib24","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1572-0241.2000.01669.x","article-title":"Proximal migration of esophageal acid perfusions during waking and sleep","volume":"95","author":"Orr","year":"2000","journal-title":"Am J Gastroenterol"},{"key":"10.1378\/chest.06-2264_bib25","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1111\/j.1572-0241.2003.07398.x","article-title":"Ambulatory esophageal pH monitoring using a wireless system","volume":"98","author":"Pandolfino","year":"2003","journal-title":"Am J Gastroenterol"},{"key":"10.1378\/chest.06-2264_bib26","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1007\/BF01300382","article-title":"Normal 24-hr ambulatory esophageal pH values: influence of study center, pH electrode, age, and gender","volume":"37","author":"Richter","year":"1992","journal-title":"Dig Dis Sci"},{"key":"10.1378\/chest.06-2264_bib27","first-page":"81","article-title":"Respiratory function and gastro-esophageal reflux during chronic bronchitis","volume":"18","author":"David","year":"1982","journal-title":"Bull Eur Physiopathol Respir"},{"key":"10.1378\/chest.06-2264_bib28","first-page":"327","article-title":"Gastroesophageal reflux in patients with asthma and chronic bronchitis","volume":"135","author":"Duculone","year":"1987","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.06-2264_bib29","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1023\/B:DDAS.0000043372.98660.82","article-title":"Proximal sensor data from routine dual-sensor esophageal pH monitoring is often inaccurate","volume":"49","author":"McCollough","year":"2004","journal-title":"Dig Dis Sci"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001236921537495X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001236921537495X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T08:29:30Z","timestamp":1546936170000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001236921537495X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["S001236921537495X"],"URL":"https:\/\/doi.org\/10.1378\/chest.06-2264","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[2007,6]]}}}