{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:04:51Z","timestamp":1773291891326,"version":"3.50.1"},"reference-count":45,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T00:00:00Z","timestamp":1193875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chest"],"published-print":{"date-parts":[[2007,11]]},"DOI":"10.1378\/chest.07-0389","type":"journal-article","created":{"date-parts":[[2007,10,2]],"date-time":"2007-10-02T00:24:38Z","timestamp":1191284678000},"page":"1532-1539","source":"Crossref","is-referenced-by-count":15,"title":["Platelet Activation in Coronary Artery Disease"],"prefix":"10.1016","volume":"132","author":[{"given":"Rumi J.","family":"Jaumdally","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chetan","family":"Varma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew D.","family":"Blann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"MacFadyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory Y.H.","family":"Lip","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1378\/chest.07-0389_bib1","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/j.jacc.2005.01.034","article-title":"Resistance to clopidogrel: a review of the evidence","volume":"45","author":"Nguyen","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"10.1378\/chest.07-0389_bib2","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1056\/NEJM199808133390704","article-title":"Inhibition of platelet glycoprotein IIb\/IIIa with eptifibatide in patients with acute coronary syndromes","volume":"339","author":"PURSUIT Trial Investigators","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.07-0389_bib3","first-page":"1488","article-title":"Inhibition of the platelet glycoprotein IIb\/IIIa receptor with tirofiban in unstable angina and non-Q-wave myocardial infarction [published correction appears in N Engl J Med 1998; 339:415]","volume":"38","author":"PRISM-PLUS Study Investigators","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.07-0389_bib4","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1056\/NEJM199404073301402","article-title":"Use of a monoclonal antibody directed against the platelet glycoprotein IIb\/IIIa receptor in high-risk coronary angioplasty","volume":"330","author":"The EPIC Investigators","year":"1994","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.07-0389_bib5","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.ahj.2005.08.002","volume":"151","author":"Schuhlen","year":"2006","journal-title":"Am Heart J"},{"key":"10.1378\/chest.07-0389_bib6","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1001\/jama.295.13.joc60034","article-title":"Abciximab in patients with acute coronary syndromes undergoing percutaneous coronary intervention after clopidogrel pretreatment: the ISAR-REACT 2 randomized trial","volume":"295","author":"Kastrati","year":"2006","journal-title":"JAMA"},{"key":"10.1378\/chest.07-0389_bib7","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1093\/eurheartj\/16.suppl_L.63","article-title":"Prevention and management of thrombotic complications during coronary interventions: combination therapy with antithrombins, anti-platelets, and\/or thrombolytics; risks and benefits","volume":"16","author":"Neuhaus","year":"1995","journal-title":"Eur Heart J"},{"key":"10.1378\/chest.07-0389_bib8","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/0092-8674(93)80055-J","article-title":"Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice","volume":"74","author":"Mayadas","year":"1993","journal-title":"Cell"},{"key":"10.1378\/chest.07-0389_bib9","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1016\/j.ehj.2003.08.021","article-title":"The adhesion molecule P-selectin and cardiovascular disease","volume":"24","author":"Blann","year":"2003","journal-title":"Eur Heart J"},{"key":"10.1378\/chest.07-0389_bib10","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1161\/01.CIR.0000033220.97592.9A","article-title":"Plasma von Willebrand factor and soluble p-selectin as indices of endothelial damage and platelet activation in 1321 patients with nonvalvular atrial fibrillation: relationship to stroke risk factors","volume":"106","author":"Conway","year":"2002","journal-title":"Circulation"},{"key":"10.1378\/chest.07-0389_bib11","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1080\/07853890410018916-1","article-title":"Platelet adhesion in hypertension: application of a novel assay of platelet adhesion","volume":"37","author":"Nadar","year":"2005","journal-title":"Ann Med"},{"key":"10.1378\/chest.07-0389_bib12","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1161\/01.CIR.0000129773.70647.94","article-title":"Soluble CD40 ligand, soluble P-selectin, interleukin-6, and tissue factor in diabetes mellitus: relationships to cardiovascular disease and risk factor intervention","volume":"109","author":"Lim","year":"2004","journal-title":"Circulation"},{"key":"10.1378\/chest.07-0389_bib13","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1161\/01.ATV.0000029781.31325.66","article-title":"Interrelationships among circulating interleukin-6, C-reactive protein, and traditional cardiovascular risk factors in women","volume":"22","author":"Bermudez","year":"2002","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1378\/chest.07-0389_bib14","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1182\/blood.V98.4.1047","article-title":"The inflammatory action of CD40 ligand (CD154) expressed on activated human platelets is temporarily limited by coexpressed CD40","volume":"98","author":"Henn","year":"2001","journal-title":"Blood"},{"key":"10.1378\/chest.07-0389_bib15","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1080\/09537100075760","article-title":"Shape change in human platelets: measurement with a channelyzer and visualisation by electron microscopy","volume":"11","author":"Jagroop","year":"2000","journal-title":"Platelets"},{"key":"10.1378\/chest.07-0389_bib16","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/S0272-2712(18)30418-9","article-title":"Usefulness of the mean platelet volume","volume":"13","author":"Threatte","year":"1993","journal-title":"Clin Lab Med"},{"key":"10.1378\/chest.07-0389_bib17","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1053\/euhj.1997.0747","article-title":"Changes in platelet size and count in unstable angina compared to stable angina or non-cardiac chest pain","volume":"19","author":"Pizzulli","year":"1998","journal-title":"Eur Heart J"},{"key":"10.1378\/chest.07-0389_bib18","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1097\/00001721-199603000-00011","article-title":"Platelet size: measurement, physiology and vascular disease","volume":"7","author":"Bath","year":"1996","journal-title":"Blood Coagul Fibrinolysis"},{"key":"10.1378\/chest.07-0389_bib19","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.amjmed.2003.09.021","article-title":"Prediction of outcome after percutaneous coronary intervention for the acute coronary syndrome","volume":"115","author":"Kini","year":"2003","journal-title":"Am J Med"},{"key":"10.1378\/chest.07-0389_bib20","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.jacc.2005.03.065","article-title":"Mean platelet volume on admission predicts impaired reperfusion and long-term mortality in acute myocardial infarction treated with primary percutaneous coronary intervention","volume":"19; 46","author":"Huczek","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"10.1378\/chest.07-0389_bib21","doi-asserted-by":"crossref","first-page":"391","DOI":"10.2143\/AC.59.4.2005204","article-title":"The relationship between preprocedural platelet size and subsequent in-stent restenosis","volume":"59","author":"Norgaz","year":"2004","journal-title":"Acta Cardiol"},{"key":"10.1378\/chest.07-0389_bib22","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1053\/euhj.2000.2301","article-title":"Management of acute coronary syndromes: acute coronary syndromes without persistent ST segment elevation; recommendations of the Task Force of the European Society of Cardiology","volume":"21","author":"Bertrand","year":"2000","journal-title":"Eur Heart J"},{"issue":"suppl","key":"10.1378\/chest.07-0389_bib23","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1161\/01.CIR.51.4.5","article-title":"A reporting system on patients evaluated for coronary artery disease: report of the Ad Hoc Committee for Grading of Coronary Artery Disease, Council on Cardiovascular Surgery, American Heart Association","volume":"51","author":"Austen","year":"1975","journal-title":"Circulation"},{"key":"10.1378\/chest.07-0389_bib24","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1023\/A:1012927606107","article-title":"Platelet reactivity in coronary ostial blood: a reflection of the thrombotic state accompanying plaque rupture and of the adequacy of anti-thrombotic therapy","volume":"12","author":"Kabbani","year":"2001","journal-title":"J Thromb Thrombolysis"},{"key":"10.1378\/chest.07-0389_bib25","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1097\/00019501-199607000-00007","article-title":"Early detection of platelet activation after coronary angioplasty","volume":"7","author":"Inoue","year":"1996","journal-title":"Coron Artery Dis"},{"key":"10.1378\/chest.07-0389_bib26","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1378\/chest.128.1.36","article-title":"Percutaneous transluminal mitral valvuloplasty reduces circulating soluble CD40 ligand in rheumatic mitral stenosis","volume":"128","author":"Chen","year":"2005","journal-title":"Chest"},{"key":"10.1378\/chest.07-0389_bib27","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.amjcard.2003.09.003","article-title":"Increased coronary arterial release of interleukin-1 receptor antagonist and soluble CD40 ligand indicative of inflammation associated with culprit coronary plaques","volume":"93","author":"Aggarwal","year":"2004","journal-title":"Am J Cardiol"},{"key":"10.1378\/chest.07-0389_bib28","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1097\/00001721-200011020-00008","article-title":"Platelets and cytokines in concert with endothelial activation in patients with peripheral arterial occlusive disease","volume":"11","author":"Tsakiris","year":"2000","journal-title":"Blood Coagul Fibrinolysis"},{"key":"10.1378\/chest.07-0389_bib29","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1515\/CCLM.2004.232","article-title":"Time course of systemic markers of inflammation in patients presenting with acute coronary syndromes","volume":"42","author":"Brueckmann","year":"2004","journal-title":"Clin Chem Lab Med"},{"key":"10.1378\/chest.07-0389_bib30","doi-asserted-by":"crossref","first-page":"e162","DOI":"10.1161\/01.ATV.0000138073.91195.70","article-title":"CD40L-positive platelets induce CD40L expression de novo in endothelial cells: adding a loop to microvascular inflammation","volume":"24","author":"Danese","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1378\/chest.07-0389_bib31","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0049-3848(88)90188-0","article-title":"Transcoronary platelet activation and consumption in coronary artery disease: studies at rest","volume":"50","author":"Mant","year":"1988","journal-title":"Thromb Res"},{"key":"10.1378\/chest.07-0389_bib32","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/ccd.1810110304","article-title":"Failure of percutaneous transluminal coronary angioplasty to stimulate platelet and prostaglandin activity","volume":"11","author":"Stine","year":"1985","journal-title":"Cathet Cardiovasc Diagn"},{"key":"10.1378\/chest.07-0389_bib33","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1152\/ajpheart.01086.2004","article-title":"Endothelial dysfunction occurs in peripheral circulation patients with acute and stable coronary artery disease","volume":"289","author":"Thanyasiri","year":"2005","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1378\/chest.07-0389_bib34","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1161\/01.CIR.0000137972.74120.12","article-title":"Loading with 600 mg clopidogrel in patients with coronary artery disease with and without chronic clopidogrel therapy","volume":"110","author":"Kastrati","year":"2004","journal-title":"Circulation"},{"key":"10.1378\/chest.07-0389_bib35","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1046\/j.1365-2796.2002.01027.x","article-title":"Individual variations of platelet inhibition after loading doses of clopidogrel","volume":"252","author":"Jaremo","year":"2002","journal-title":"J Intern Med"},{"key":"10.1378\/chest.07-0389_bib36","first-page":"251","article-title":"Decreased plasma soluble P-selectin level in coronary sinus after successful coronary angioplasty in patients with unstable angina","volume":"33","author":"Doi","year":"1999","journal-title":"J Cardiol"},{"key":"10.1378\/chest.07-0389_bib37","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1159\/000006917","article-title":"Serum levels of circulating adhesion molecules after coronary angioplasty","volume":"91","author":"Inoue","year":"1999","journal-title":"Cardiology"},{"key":"10.1378\/chest.07-0389_bib38","first-page":"180","article-title":"Intracoronary inflammatory markers after percutaneous coronary interventions","volume":"85","author":"Salgado Filho","year":"2005","journal-title":"Ar Qbras Cardiol"},{"key":"10.1378\/chest.07-0389_bib39","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0167-5273(00)00430-7","article-title":"Relationship between intracoronary and peripheral expression of soluble cell adhesion molecules","volume":"77","author":"Mulvihill","year":"2001","journal-title":"Int J Cardiol"},{"key":"10.1378\/chest.07-0389_bib40","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1067\/mhj.2002.119372","article-title":"Effect of 300- and 450-mg clopidogrel loading doses on membrane and soluble P-selectin in patients undergoing coronary stent implantation","volume":"143","author":"Seyfarth","year":"2002","journal-title":"Am Heart J"},{"key":"10.1378\/chest.07-0389_bib41","first-page":"23","article-title":"Effects of carbon-coated coronary stents on the markers of inflammation, thrombin generation and platelet and endothelial activation","volume":"4","author":"Tomai","year":"2003","journal-title":"Ital Heart J"},{"key":"10.1378\/chest.07-0389_bib42","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1097\/00019501-200412000-00003","article-title":"Soluble CD40 ligand is an early initiator of inflammation after coronary intervention","volume":"15","author":"Aggarwal","year":"2004","journal-title":"Coron Artery Dis"},{"key":"10.1378\/chest.07-0389_bib43","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.1161\/01.CIR.0000103700.05109.0D","article-title":"Preprocedural level of soluble CD40L is predictive of enhanced inflammatory response and restenosis after coronary angioplasty","volume":"108","author":"Cipollone","year":"2003","journal-title":"Circulation"},{"key":"10.1378\/chest.07-0389_bib44","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.clinthera.2006.06.010","article-title":"Randomized comparison of the effects of ASA plus clopidogrel versus ASA alone on early platelet activation in acute coronary syndromes with elevated high-sensitivity C-reactive protein and soluble CD40 ligand levels","volume":"28","author":"Vavuranakis","year":"2006","journal-title":"Clin Ther"},{"key":"10.1378\/chest.07-0389_bib45","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s11239-006-9048-x","article-title":"Effects of low osmolar contrast (iomeprol) on haemorheology and platelet activation in patients with coronary artery disease","volume":"23","author":"Jaumdally","year":"2007","journal-title":"J Thromb Thrombolysis"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215512683?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215512683?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T12:51:59Z","timestamp":1556887919000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369215512683"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11]]},"references-count":45,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,11]]}},"alternative-id":["S0012369215512683"],"URL":"https:\/\/doi.org\/10.1378\/chest.07-0389","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[2007,11]]}}}