{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T11:07:11Z","timestamp":1769166431382,"version":"3.49.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chest"],"published-print":{"date-parts":[[2008,9]]},"DOI":"10.1378\/chest.08-0350","type":"journal-article","created":{"date-parts":[[2008,7,19]],"date-time":"2008-07-19T00:54:28Z","timestamp":1216428868000},"page":"559-567","source":"Crossref","is-referenced-by-count":103,"title":["Increased Major Bleeding Complications Related to Triple Antithrombotic Therapy Usage in Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Artery Stenting"],"prefix":"10.1016","volume":"134","author":[{"given":"Sergio","family":"Manzano-Fern\u00e1ndez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco J.","family":"Pastor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Mar\u00edn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Cambronero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cesar","family":"Caro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domingo A.","family":"Pascual-Figal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris P.","family":"Garrido","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Pinar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariano","family":"Vald\u00e9s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory Y.H.","family":"Lip","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1378\/chest.08-0350_bib1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1067\/mhj.2001.115589","article-title":"Post-myocardial infarction risk stratification in elderly patients","volume":"142","author":"Alexander","year":"2001","journal-title":"Am Heart J"},{"key":"10.1378\/chest.08-0350_bib2","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/0002-9149(94)90363-8","article-title":"Prevalence of atrial fibrillation in elderly subjects (the Cardiovascular Health Study)","volume":"74","author":"Furberg","year":"1994","journal-title":"Am J Cardiol"},{"key":"10.1378\/chest.08-0350_bib3","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1161\/01.STR.30.6.1223","article-title":"Factors associated with ischemic stroke during aspirin therapy in atrial fibrillation: analysis of 2012 participants in the SPAF I-III clinical trials: the Stroke Prevention in Atrial Fibrillation (SPAF) Investigators","volume":"30","author":"Hart","year":"1999","journal-title":"Stroke"},{"key":"10.1378\/chest.08-0350_bib4","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1093\/eurheartj\/ehm265","article-title":"Major bleeding after PCI: where is our crystal ball?","volume":"28","author":"Spencer","year":"2007","journal-title":"Eur Heart J"},{"key":"10.1378\/chest.08-0350_bib5","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1001\/jama.288.19.2411","article-title":"Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial","volume":"288","author":"Steinhubl","year":"2002","journal-title":"JAMA"},{"key":"10.1378\/chest.08-0350_bib6","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1056\/NEJM199812033392303","article-title":"A clinical trial comparing three antithrombotic drug regimens after coronary-artery stenting: Stent Anticoagulation Restenosis Study Investigators","volume":"339","author":"Leon","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.08-0350_bib7","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1016\/S0140-6736(06)68845-4","article-title":"Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial Fibrillation Clopidogrel Trial With Irbesartan for Prevention of Vascular Events (ACTIVE W): a randomised controlled trial","volume":"367","author":"Connolly","year":"2006","journal-title":"Lancet"},{"key":"10.1378\/chest.08-0350_bib8","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.jacc.2007.11.035","article-title":"Anticoagulant and antiplatelet therapy use in 426 patients with atrial fibrillation undergoing percutaneous coronary intervention and stent implantation: implications for bleeding risk and prognosis","volume":"51","author":"Ruiz-Nodar","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"10.1378\/chest.08-0350_bib9","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1093\/eurheartj\/ehl488","article-title":"Safety and efficacy of combined antiplatelet-warfarin therapy after coronary stenting","volume":"28","author":"Karjalainen","year":"2007","journal-title":"Eur Heart J"},{"key":"10.1378\/chest.08-0350_bib10","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1097\/MCA.0b013e328012a964","article-title":"Periprocedural and medium-term antithrombotic strategies in patients with an indication for long-term anticoagulation undergoing coronary angiography and intervention","volume":"18","author":"Rubboli","year":"2007","journal-title":"Coron Artery Dis"},{"key":"10.1378\/chest.08-0350_bib11","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1592\/phco.27.5.691","article-title":"Risk of major bleeding with concomitant dual antiplatelet therapy after percutaneous coronary intervention in patients receiving long-term warfarin therapy","volume":"27","author":"DeEugenio","year":"2007","journal-title":"Pharmacotherapy"},{"key":"10.1378\/chest.08-0350_bib12","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/ccd.20733","article-title":"Short-term triple therapy with aspirin, warfarin, and a thienopyridine among patients undergoing percutaneous coronary intervention","volume":"68","author":"Porter","year":"2006","journal-title":"Catheter Cardiovasc Interv"},{"key":"10.1378\/chest.08-0350_bib13","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.ahj.2003.06.004","article-title":"Safety and efficacy of aspirin, clopidogrel, and warfarin after coronary stent placement in patients with an indication for anticoagulation","volume":"147","author":"Orford","year":"2004","journal-title":"Am Heart J"},{"key":"10.1378\/chest.08-0350_bib14","first-page":"162","article-title":"Combination therapy with aspirin, clopidogrel and warfarin following coronary stenting is associated with a significant risk of bleeding","volume":"18","author":"Khurram","year":"2006","journal-title":"J Invasive Cardiol"},{"key":"10.1378\/chest.08-0350_bib15","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1540-8183.2005.04065.x","article-title":"Evaluation of safety of warfarin in combination with antiplatelet therapy for patients treated with coronary stents for acute myocardial infarction","volume":"18","author":"Mattichak","year":"2005","journal-title":"J Interv Cardiol"},{"key":"10.1378\/chest.08-0350_bib16","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1016\/S0735-1097(01)01586-8","volume":"38","year":"2001","journal-title":"J Am Coll Cardiol"},{"key":"10.1378\/chest.08-0350_bib17","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1001\/jama.285.22.2864","article-title":"Validation of clinical classification schemes for predicting stroke: results from the National Registry of Atrial Fibrillation","volume":"285","author":"Gage","year":"2001","journal-title":"JAMA"},{"key":"10.1378\/chest.08-0350_bib18","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1056\/NEJM199805213382102","volume":"338","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.08-0350_bib19","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/S0002-8703(03)00165-0","article-title":"Combining enoxaparin and glycoprotein IIb\/IIIa antagonists for the treatment of acute coronary syndromes: final results of the National Investigators Collaborating on Enoxaparin-3 (NICE-3) study","volume":"146","author":"Ferguson","year":"2003","journal-title":"Am Heart J"},{"key":"10.1378\/chest.08-0350_bib20","first-page":"45","article-title":"Enoxaparin vs unfractionated heparin in high-risk patients with non-ST-segment elevation acute coronary syndromes managed with an intended early invasive strategy: primary results of the SYNERGY randomized trial","volume":"292","author":"Ferguson","year":"2004","journal-title":"JAMA"},{"key":"10.1378\/chest.08-0350_bib21","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1093\/eurheartj\/ehl038","article-title":"Quality of life after coronary revascularization in the elderly","volume":"27","author":"Graham","year":"2006","journal-title":"Eur Heart J"},{"key":"10.1378\/chest.08-0350_bib22","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S0003-4975(01)03576-7","article-title":"Morbidity after procurement of radial arteries in diabetic patients and the elderly undergoing coronary revascularization","volume":"73","author":"Reddy","year":"2002","journal-title":"Ann Thorac Surg"},{"key":"10.1378\/chest.08-0350_bib23","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ahj.2004.06.003","article-title":"GRACE Investigators: impact of age on management and outcome of acute coronary syndrome: observations from the Global Registry of Acute Coronary Events (GRACE)","volume":"149","author":"Avezum","year":"2005","journal-title":"Am Heart J"},{"key":"10.1378\/chest.08-0350_bib24","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0002-9149(02)03247-2","article-title":"Interactions between age, outcome of acute coronary syndromes, and tirofiban therapy","volume":"91","author":"Januzzi","year":"2003","journal-title":"Am J Cardiol"},{"key":"10.1378\/chest.08-0350_bib25","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1093\/eurheartj\/ehm186","article-title":"Combining warfarin and antiplatelet therapy after coronary stenting in the Global Registry of Acute Coronary Events: is it safe and effective to use just one antiplatelet agent?","volume":"28","author":"Nguyen","year":"2007","journal-title":"Eur Heart J"},{"key":"10.1378\/chest.08-0350_bib26","first-page":"231","article-title":"Hemorrhagic complications of oral anticoagulant therapy: results of a prospective multicenter study ISCOAT (Italian Study on Complications of Oral Anticoagulant Therapy)","volume":"27","author":"Palareti","year":"1997","journal-title":"G Ital Cardiol"},{"key":"10.1378\/chest.08-0350_bib27","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.amjcard.2004.06.058","article-title":"Impact of anemia on outcomes of patients undergoing percutaneous coronary interventions","volume":"94","author":"Nikolsky","year":"2004","journal-title":"Am J Cardiol"},{"key":"10.1378\/chest.08-0350_bib28","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.jacc.2004.03.080","article-title":"Impact of anemia in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention: analysis from the Controlled Abciximab and Device Investigation to Lower Late Angioplasty Complications (CADILLAC) Trial","volume":"44","author":"Nikolsky","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"10.1378\/chest.08-0350_bib29","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/j.amjcard.2007.01.027","article-title":"Effect of anemia on hemorrhagic complications and mortality following percutaneous coronary intervention","volume":"99","author":"Voeltz","year":"2007","journal-title":"Am J Cardiol"},{"key":"10.1378\/chest.08-0350_bib30","doi-asserted-by":"crossref","first-page":"e107","DOI":"10.1161\/STROKEAHA.107.492488","article-title":"Combining antiplatelet drugs and oral anticoagulant therapy in atrial fibrillation: acute coronary syndromes and\/or percutaneous coronary intervention\/stenting revisited","volume":"38","author":"Watson","year":"2007","journal-title":"Stroke"},{"key":"10.1378\/chest.08-0350_bib31","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1056\/NEJM198504043121437","article-title":"The Thrombolysis in Myocardial Infarction (TIMI) trial: phase I findings","volume":"312","author":"TIMI Study Group","year":"1985","journal-title":"N Engl J Med"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369208602561?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369208602561?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T04:59:19Z","timestamp":1545886759000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369208602561"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,9]]}},"alternative-id":["S0012369208602561"],"URL":"https:\/\/doi.org\/10.1378\/chest.08-0350","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[2008,9]]}}}