{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T21:49:38Z","timestamp":1769636978149,"version":"3.49.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chest"],"published-print":{"date-parts":[[2008,9]]},"DOI":"10.1378\/chest.08-0366","type":"journal-article","created":{"date-parts":[[2008,7,19]],"date-time":"2008-07-19T00:54:28Z","timestamp":1216428868000},"page":"552-558","source":"Crossref","is-referenced-by-count":26,"title":["Exercise-Induced Asthma May Be Associated With Diminished Sweat Secretion Rates in Humans"],"prefix":"10.1016","volume":"134","author":[{"given":"Chan","family":"Park","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Stafford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Warren","family":"Lockette","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1378\/chest.08-0366_bib1","first-page":"459","article-title":"Sensitivity to heat and water loss at rest and during exercise in asthmatic patients","volume":"63","author":"Anderson","year":"1982","journal-title":"Eur J Respir Dis"},{"key":"10.1378\/chest.08-0366_bib2","first-page":"239","article-title":"Influence of temperature and relative humidity of inhaled gas on exercise-induced asthma","volume":"63","author":"Bundgaarad","year":"1982","journal-title":"Eur J Respir Dis"},{"key":"10.1378\/chest.08-0366_bib3","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1378\/chest.121.6.1806","article-title":"Airway dehydration: a therapeutic target in asthma","volume":"121","author":"Moloney","year":"2002","journal-title":"Chest"},{"key":"10.1378\/chest.08-0366_bib4","doi-asserted-by":"crossref","first-page":"583","DOI":"10.2165\/00007256-200232090-00004","article-title":"Exercise-induced bronchospasm in the elite athlete","volume":"32","author":"Rundell","year":"2002","journal-title":"Sports Med"},{"key":"10.1378\/chest.08-0366_bib5","doi-asserted-by":"crossref","first-page":"41288","DOI":"10.1074\/jbc.M107257200","article-title":"Aquaporin-5 dependent fluid secretion in airway submucosal glands","volume":"276","author":"Song","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1378\/chest.08-0366_bib6","doi-asserted-by":"crossref","first-page":"9070","DOI":"10.1074\/jbc.275.12.9070","article-title":"Hypertonic induction of aquaporin-5 expression through an ERK-dependent pathway","volume":"275","author":"Hoffert","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1378\/chest.08-0366_bib7","doi-asserted-by":"crossref","first-page":"C1549","DOI":"10.1152\/ajpcell.1997.273.5.C1549","article-title":"Aquaporins in complex tissues: iI Subcellular distribution in respiratory and glandular tissues of the rat","volume":"273","author":"Nielson","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1378\/chest.08-0366_bib8","doi-asserted-by":"crossref","first-page":"14114","DOI":"10.1073\/pnas.231273398","article-title":"Aquaporin-5 deficient mouse lungs are hyperresponsive to cholinergic stimulation","volume":"98","author":"Krane","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1378\/chest.08-0366_bib9","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1073\/pnas.012588099","article-title":"Functional requirement of aquaporin-5 in plasma membranes of sweat glands","volume":"99","author":"Nejsum","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1378\/chest.08-0366_bib10","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1172\/JCI8258","article-title":"Lung fluid transport in aquaporin-5 knockout mice","volume":"105","author":"Ma","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1378\/chest.08-0366_bib11","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1085\/jgp.117.6.573","article-title":"Role of aquaporin water channels in airway fluid transport, humidification, and surface liquid hydration","volume":"117","author":"Song","year":"2001","journal-title":"J Gen Physiol"},{"key":"10.1378\/chest.08-0366_bib12","doi-asserted-by":"crossref","first-page":"20071","DOI":"10.1074\/jbc.274.29.20071","article-title":"Defective secretion of saliva in transgenic mice lacking aquaporin-5 water channels","volume":"274","author":"Ma","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1378\/chest.08-0366_bib13","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1378\/chest.125.2.453","article-title":"Methacholine challenge testing: comparison of the two American Thoracic Society-recommended methods","volume":"125","author":"Wubbel","year":"2004","journal-title":"Chest"},{"key":"10.1378\/chest.08-0366_bib14","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1172\/JCI106113","article-title":"Micropuncture studies of sweat formation in cystic fibrosis patients","volume":"48","author":"Schulz","year":"1969","journal-title":"J Clin Invest"},{"key":"10.1378\/chest.08-0366_bib15","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0190-9622(89)70063-3","article-title":"Biology of sweat glands and their disorders; normal sweat gland function","volume":"20","author":"Sato","year":"1989","journal-title":"J Am Acad Dermatol"},{"key":"10.1378\/chest.08-0366_bib16","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1007\/s00424-002-0856-3","article-title":"Antisense co-suppression of G\u03b1q and G\u03b111 demonstrates that both isoforms mediate M3-receptor activated Ca2+ signaling in intact epithelial cells","volume":"444","author":"Cummins","year":"2002","journal-title":"Pflugers Arch"},{"key":"10.1378\/chest.08-0366_bib17","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s00424-002-0985-8","article-title":"Pharmacological investigation of the role of ion channels in salivary secretion","volume":"446","author":"Stummann","year":"2003","journal-title":"Pflugers Arch"},{"key":"10.1378\/chest.08-0366_bib18","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1006\/bbrc.1998.8395","article-title":"Acetylcholine acts on M3 muscarinic receptors and induces the translocation of aquaporin-5 water channel via cytosolic Ca2+ elevation in rat parotid glands","volume":"245","author":"Ishikawa","year":"1998","journal-title":"Biochem Biophys Res Comm"},{"key":"10.1378\/chest.08-0366_bib19","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0014-5793(00)01763-4","article-title":"Persistent increase in the amount of aquaporin-5 in the apical plasma membrane of rat parotid acinar cells induced by a muscarinic agonist SNI-2011","volume":"477","author":"Ishikawa","year":"2000","journal-title":"FEBS Lett"},{"key":"10.1378\/chest.08-0366_bib20","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/BF00843768","article-title":"Changes in the concentrations of Na+, K+, and Cl- in secretion from the skin during progressive increases in exercise intensity","volume":"64","author":"Tanaka","year":"1992","journal-title":"Eur J Appl Physiol"},{"key":"10.1378\/chest.08-0366_bib21","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1378\/chest.123.5.1467","article-title":"Measurement of nasal potential difference in mild asthmatics","volume":"123","author":"Chung","year":"2003","journal-title":"Chest"},{"key":"10.1378\/chest.08-0366_bib22","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1111\/j.1745-7254.2007.00608.x","article-title":"Decreased expression of human aquaporin-5 correlated with mucus overproduction in airways of chronic obstructive pulmonary disease","volume":"28","author":"Wang","year":"2007","journal-title":"Acta Pharmacol Sin"},{"key":"10.1378\/chest.08-0366_bib23","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1172\/JCI102448","article-title":"Studies on the combined use of measurements of sweat electrolyte composition and rate of sweating as an index of adrenal cortical activity","volume":"30","author":"Locke","year":"1951","journal-title":"J Clin Invest"},{"key":"10.1378\/chest.08-0366_bib24","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1152\/jappl.1986.61.3.967","article-title":"Plasma aldosterone and sweat sodium concentrations after exercise and heat acclimation","volume":"61","author":"Kirby","year":"1986","journal-title":"J Appl Physiol"},{"key":"10.1378\/chest.08-0366_bib25","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1152\/japplphysiol.00150.2002","article-title":"Decreased airway narrowing and smooth muscle contraction in hyperresponsive pigs","volume":"93","author":"Turner","year":"2002","journal-title":"J Appl Physiol"},{"key":"10.1378\/chest.08-0366_bib26","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1177\/154405910308200614","article-title":"Age-related decreases in the response of aquaporin-5 to acetylcholine in rat parotid glands","volume":"82","author":"Inoue","year":"2003","journal-title":"J Dent Res"},{"key":"10.1378\/chest.08-0366_bib27","doi-asserted-by":"crossref","first-page":"32173","DOI":"10.1074\/jbc.M305149200","article-title":"Cyclic AMP regulates aquaporin-5 expression at both transcriptional and post-transcriptional levels through a protein kinase A pathway","volume":"278","author":"Yang","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1378\/chest.08-0366_bib28","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1093\/hmg\/ddg208","article-title":"Chromosome 12q harbors multiple genetic loci related to asthma and asthma-related phenotypes","volume":"12","author":"Raby","year":"2003","journal-title":"Hum Mol Genet"},{"key":"10.1378\/chest.08-0366_bib29","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1046\/j.1365-2222.2000.00954.x","article-title":"Studies on linkage and association of atopy with chromosomal region 12q13\u201324","volume":"30","author":"Heinzmann","year":"2000","journal-title":"Clin Exp Allergy"},{"key":"10.1378\/chest.08-0366_bib30","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0091-6749(99)70398-2","article-title":"Dense mapping of chromosome 12q13.12q23.3 and linkage to asthma and atopy","volume":"104","author":"Barnes","year":"1999","journal-title":"J Allergy Clin Immunol"},{"key":"10.1378\/chest.08-0366_bib31","doi-asserted-by":"crossref","first-page":"8599","DOI":"10.1074\/jbc.271.15.8599","article-title":"Human Aquaporin-5 gene: molecular characterization and chromosomal localization","volume":"271","author":"Lee","year":"1996","journal-title":"J Biol Chem"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001236920860255X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001236920860255X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,12]],"date-time":"2019-05-12T19:54:28Z","timestamp":1557690868000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001236920860255X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,9]]}},"alternative-id":["S001236920860255X"],"URL":"https:\/\/doi.org\/10.1378\/chest.08-0366","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[2008,9]]}}}