{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T22:27:04Z","timestamp":1770503224283,"version":"3.49.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chest"],"published-print":{"date-parts":[[2008,10]]},"DOI":"10.1378\/chest.08-0763","type":"journal-article","created":{"date-parts":[[2008,10,8]],"date-time":"2008-10-08T16:38:14Z","timestamp":1223483894000},"page":"733-739","source":"Crossref","is-referenced-by-count":47,"title":["Usefulness of Exhaled Nitric Oxide and Sputum Eosinophils in the Long-term Control of Eosinophilic Asthma"],"prefix":"10.1016","volume":"134","author":[{"given":"Mario","family":"Malerba","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatrice","family":"Ragnoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Radaeli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Tantucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1378\/chest.08-0763_bib1","first-page":"84","article-title":"Pathophysiology of asthma","volume":"23","author":"Barnes","year":"2003","journal-title":"Eur Respir J"},{"key":"10.1378\/chest.08-0763_bib2","author":"Global Initiative for Asthma"},{"key":"10.1378\/chest.08-0763_bib3","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1136\/thx.53.2.91","article-title":"Correlation between exhaled nitric oxide, sputum eosinophils, and methacholine responsiveness in patients with mild asthma","volume":"53","author":"Jatakanon","year":"1998","journal-title":"Thorax"},{"key":"10.1378\/chest.08-0763_bib4","first-page":"883","article-title":"Relationship of exhaled nitric oxide to clinical and inflammatory markers of persistent asthma in children","volume":"112","author":"Strunk","year":"2003","journal-title":"Am Acad Allergy Asthma Immunol"},{"key":"10.1378\/chest.08-0763_bib5","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1183\/09031936.93.06091368","article-title":"Increased amount of nitric oxide in exhaled air of asthmatics","volume":"6","author":"Alving","year":"1993","journal-title":"Eur Respir J"},{"key":"10.1378\/chest.08-0763_bib6","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1164\/ajrccm.159.3.9805103","article-title":"Expired nitric oxide and airway obstruction in asthma patients with an acute exacerbation","volume":"159","author":"Crater","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.08-0763_bib7","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1164\/ajrccm.153.1.8542158","article-title":"Inhaled antileukotrienes decrease nitric oxide in exhaled air of asthmatic patients","volume":"153","author":"Kharitonov","year":"1996","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.08-0763_bib8","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1164\/ajrccm.152.2.7633745","article-title":"Expired nitric oxide levels during treatment of acute asthma","volume":"152","author":"Massaro","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.08-0763_bib9","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1136\/thx.47.1.25","article-title":"Use of induced sputum cell counts to investigate airway inflammation in asthma","volume":"47","author":"Pin","year":"1992","journal-title":"Thorax"},{"key":"10.1378\/chest.08-0763_bib10","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1183\/09031936.99.13101599","article-title":"Prednisone-dependent asthma: inflammatory indices in induced sputum","volume":"13","author":"Pizzichini","year":"1999","journal-title":"Eur Respir J"},{"key":"10.1378\/chest.08-0763_bib11","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1183\/09031936.98.12051084","article-title":"An inhaled steroid improves markers of airway inflammation in patients with mild asthma","volume":"12","author":"Jatakanon","year":"1998","journal-title":"Eur Respir J"},{"key":"10.1378\/chest.08-0763_bib12","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1056\/NEJMoa043596","article-title":"Use of exhaled nitric oxide measurements to guide treatment in chronic asthma","volume":"352","author":"Smith","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.08-0763_bib13","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1164\/rccm.200503-458OC","article-title":"Titrating steroids on exhaled nitric oxide in children with asthma: a randomized controlled trial","volume":"172","author":"Pijnenburg","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.08-0763_bib14","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1164\/rccm.200610-1427OC","article-title":"The use of exhaled nitric oxide to guide asthma management: a randomized controlled trial","volume":"176","author":"Shaw","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.08-0763_bib15","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1016\/S0140-6736(02)11679-5","article-title":"Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial","volume":"360","author":"Green","year":"2002","journal-title":"Lancet"},{"key":"10.1378\/chest.08-0763_bib16","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1183\/09031936.06.00137704","article-title":"Determining asthma treatment by monitoring sputum cell counts: effect on exacerbations","volume":"27","author":"Jayaram","year":"2006","journal-title":"Eur Respir J"},{"key":"10.1378\/chest.08-0763_bib17","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1177\/147323000603400202","article-title":"Strategy aimed at reduction of sputum eosinophils decreases exacerbation rate in patients with asthma","volume":"34","author":"Chlumsky","year":"2006","journal-title":"J Int Med Res"},{"key":"10.1378\/chest.08-0763_bib18","article-title":"Tailored interventions based on sputum eosinophils versus clinical symptoms for asthma in children and adults","volume":"2","author":"Petsky","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1378\/chest.08-0763_bib19","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.rmed.2005.08.012","article-title":"Identifying \u201cwell controlled\u201d and \u201cnot well-controlled\u201d asthma using the Asthma Control Questionnaire","volume":"100","author":"Juniper","year":"2005","journal-title":"Respir Med"},{"key":"10.1378\/chest.08-0763_bib20","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1183\/09031936.97.10061205","article-title":"Measurement of lung volumes in humans: review and recommendations from an ATS\/ERS workshop","volume":"10","author":"Clausen","year":"1997","journal-title":"Eur Respir J"},{"key":"10.1378\/chest.08-0763_bib21","first-page":"309","article-title":"Guidelines for methacholine and exercise challenge testing","volume":"161","author":"American Thoracic Society","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.08-0763_bib22","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1164\/rccm.200406-710ST","article-title":"ATS\/ERS recommendations for standardized procedures for online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005","volume":"171","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.08-0763_bib23","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/1465-9921-7-94","article-title":"Reference values for exhaled nitric oxide (REVENO) study","volume":"7","author":"Olivieri","year":"2006","journal-title":"Respir Res"},{"key":"10.1378\/chest.08-0763_bib24","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1136\/thx.2005.043471","article-title":"Neutrophilic inflammation and IL-8 levels in induced sputum of \u03b1-1-antitrypsin PiMZ subjects","volume":"61","author":"Malerba","year":"2006","journal-title":"Thorax"},{"key":"10.1378\/chest.08-0763_bib25","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1183\/09031936.00112306","article-title":"Bronchoalveolar lavage, sputum and exhaled clinically relevant inflammatory markers: values in healthy adults","volume":"30","author":"Balbi","year":"2007","journal-title":"Eur Respir J"},{"key":"10.1378\/chest.08-0763_bib26","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1164\/ajrccm.164.5.2012125","article-title":"The predictive value of exhaled nitric oxide measurements in assessing changes in asthma control","volume":"164","author":"Jones","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.08-0763_bib27","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1378\/chest.07-1587","article-title":"Effects of montelukast treatment and withdrawal on exhaled nitric oxide and lung function in children with asthma","volume":"132","author":"Montuschi","year":"2007","journal-title":"Chest"},{"key":"10.1378\/chest.08-0763_bib28","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1183\/09031936.99.13613919","article-title":"Exhaled nitric oxide and sputum eosinophil markers of inflammation in asthmatic children","volume":"13","author":"Piacentini","year":"1999","journal-title":"Eur Respir J"},{"key":"10.1378\/chest.08-0763_bib29","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1136\/thx.53.9.744","article-title":"Asthma control during long-term treatment with regular inhaled salbutamol and salmeterol","volume":"53","author":"Taylor","year":"1998","journal-title":"Thorax"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369208603025?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369208603025?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T09:55:12Z","timestamp":1684576512000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369208603025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["S0012369208603025"],"URL":"https:\/\/doi.org\/10.1378\/chest.08-0763","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[2008,10]]}}}