{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T08:55:11Z","timestamp":1770972911100,"version":"3.50.1"},"reference-count":43,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chest"],"published-print":{"date-parts":[[2009,10]]},"DOI":"10.1378\/chest.09-0493","type":"journal-article","created":{"date-parts":[[2009,7,10]],"date-time":"2009-07-10T20:34:06Z","timestamp":1247258046000},"page":"1055-1062","source":"Crossref","is-referenced-by-count":25,"title":["Obesity-Asthma Association"],"prefix":"10.1016","volume":"136","author":[{"given":"Akshay","family":"Sood","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clifford","family":"Qualls","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Arynchyn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William S.","family":"Beckett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myron D.","family":"Gross","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael W.","family":"Steffes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lewis J.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Holvoet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bharat","family":"Thyagarajan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"David R.","family":"Jacobs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1378\/chest.09-0493_bib1","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1164\/rccm.200303-403WS","article-title":"Obesity and asthma: directions for research","volume":"169","author":"Weiss","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.09-0493_bib2","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1373\/clinchem.2004.037630","article-title":"Plasma F2-isoprostanes and coronary artery calcification: the CARDIA Study","volume":"51","author":"Gross","year":"2005","journal-title":"Clin Chem"},{"key":"10.1378\/chest.09-0493_bib3","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1161\/01.ATV.0000058402.34138.11","article-title":"Obesity and systemic oxidative stress: clinical correlates of oxidative stress in the Framingham study","volume":"23","author":"Keaney","year":"2003","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1378\/chest.09-0493_bib4","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/sj.ijo.0803177","article-title":"Biomarkers and potential mechanisms of obesity-induced oxidant stress in humans","volume":"30","author":"Vincent","year":"2006","journal-title":"Int J Obes (Lond)"},{"key":"10.1378\/chest.09-0493_bib5","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1136\/thorax.2002.002477","article-title":"Oxidants and asthma","volume":"59","author":"Caramori","year":"2004","journal-title":"Thorax"},{"key":"10.1378\/chest.09-0493_bib6","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1164\/ajrccm.160.6.9903064","article-title":"Allergen-induced synthesis of F(2)-isoprostanes in atopic asthmatics: evidence for oxidant stress","volume":"160","author":"Dworski","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.09-0493_bib7","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1067\/mai.2003.17","article-title":"Increased oxidative stress and altered levels of antioxidants in asthma","volume":"111","author":"Nadeem","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1378\/chest.09-0493_bib8","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.rmed.2004.10.013","article-title":"Lack of systemic oxidative stress during PAF challenge in mild asthma","volume":"99","author":"Echazarreta","year":"2005","journal-title":"Respir Med"},{"key":"10.1378\/chest.09-0493_bib9","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1007\/s11745-000-0607-x","article-title":"Lipid peroxidation as determined by plasma isoprostanes is related to disease severity in mild asthma","volume":"35","author":"Wood","year":"2000","journal-title":"Lipids"},{"key":"10.1378\/chest.09-0493_bib10","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.jaci.2008.03.004","article-title":"Obesity and asthma: possible mechanisms","volume":"121","author":"Shore","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"10.1378\/chest.09-0493_bib11","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1465-9921-8-32","article-title":"Body mass index is associated with reduced exhaled nitric oxide and higher exhaled 8-isoprostanes in asthmatics","volume":"8","author":"Komakula","year":"2007","journal-title":"Respir Res"},{"key":"10.1378\/chest.09-0493_bib12","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0891-5849(99)00264-6","article-title":"Measurement of F(2)-isoprostanes as an index of oxidative stress in vivo","volume":"28","author":"Roberts","year":"2000","journal-title":"Free Radic Biol Med"},{"key":"10.1378\/chest.09-0493_bib13","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1089\/ars.2006.8.1379","article-title":"Isoprostanes and related compounds: update 2006","volume":"8","author":"Milne","year":"2006","journal-title":"Antioxid Redox Signal"},{"key":"10.1378\/chest.09-0493_bib14","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.freeradbiomed.2004.09.017","article-title":"Biomarkers of oxidative stress study II: are oxidation products of lipids, proteins, and DNA markers of CCl4 poisoning?","volume":"38","author":"Kadiiska","year":"2005","journal-title":"Free Radic Biol Med"},{"key":"10.1378\/chest.09-0493_bib15","article-title":"F(2)-isoprostanes and 2-arachidonylglycerol as biomarkers of lipid peroxidation in pigs with hepatic ischemia\/reperfusion injury","author":"Ishii","year":"2009","journal-title":"J Surg Res"},{"key":"10.1378\/chest.09-0493_bib16","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1161\/01.CIR.99.2.224","article-title":"In vivo formation of 8-iso-prostaglandin f2\u03b1 and platelet activation in diabetes mellitus: effects of improved metabolic control and vitamin E supplementation","volume":"99","author":"Davi","year":"1999","journal-title":"Circulation"},{"key":"10.1378\/chest.09-0493_bib17","doi-asserted-by":"crossref","first-page":"3230","DOI":"10.1161\/01.ATV.17.11.3230","article-title":"In vivo formation of 8-epi-prostaglandin F2 \u03b1 is increased in hypercholesterolemia","volume":"17","author":"Davi","year":"1997","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1378\/chest.09-0493_bib18","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1161\/hc3501.095287","article-title":"Oxidative stress and platelet activation in homozygous homocystinuria","volume":"104","author":"Davi","year":"2001","journal-title":"Circulation"},{"key":"10.1378\/chest.09-0493_bib19","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1164\/ajrccm.162.4.9911071","article-title":"In vivo lipid peroxidation and platelet activation in cystic fibrosis","volume":"162","author":"Ciabattoni","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.09-0493_bib20","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1080\/10715760100301461","article-title":"Supplementation with vitamin E but not with vitamin C lowers lipid peroxidation in vivo in mildly hypercholesterolemic men","volume":"35","author":"Kaikkonen","year":"2001","journal-title":"Free Radic Res"},{"key":"10.1378\/chest.09-0493_bib21","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.annepidem.2003.10.006","article-title":"Serum adiponectin in young adults: interactions with central adiposity, circulating levels of glucose, and insulin resistance: the CARDIA study","volume":"14","author":"Steffes","year":"2004","journal-title":"Ann Epidemiol"},{"key":"10.1378\/chest.09-0493_bib22","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1002\/(SICI)1099-0496(199912)28:6<394::AID-PPUL2>3.0.CO;2-6","article-title":"Race, socioeconomic factors, and area of residence are associated with asthma prevalence","volume":"28","author":"Litonjua","year":"1999","journal-title":"Pediatr Pulmonol"},{"key":"10.1378\/chest.09-0493_bib23","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1046\/j.1365-2222.2002.01524.x","article-title":"High prevalence of current asthma and active smoking effect among the elderly","volume":"32","author":"Kim","year":"2002","journal-title":"Clin Exp Allergy"},{"key":"10.1378\/chest.09-0493_bib24","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1471-2466-6-10","article-title":"Smoking, respiratory symptoms and likely asthma in young people: evidence from postal questionnaire surveys in the Wythenshawe Community Asthma Project (WYCAP)","volume":"6","author":"Frank","year":"2006","journal-title":"BMC Pulm Med"},{"key":"10.1378\/chest.09-0493_bib25","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1164\/ajrccm.164.11.2004235","article-title":"Asthma is associated with weight gain in females but not males, independent of physical activity","volume":"164","author":"Beckett","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.09-0493_bib26","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1136\/thx.2007.090803","article-title":"Association between asthma and serum adiponectin concentration in women","volume":"63","author":"Sood","year":"2008","journal-title":"Thorax"},{"key":"10.1378\/chest.09-0493_bib27","doi-asserted-by":"crossref","first-page":"L350","DOI":"10.1152\/ajplung.2000.279.2.L350","article-title":"Mice that overexpress Cu\/Zn superoxide dismutase are resistant to allergen-induced changes in airway control","volume":"279","author":"Larsen","year":"2000","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1378\/chest.09-0493_bib28","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0891-5849(02)00919-X","article-title":"Inhibition of airway inflammation and hyperreactivity by an antioxidant mimetic","volume":"33","author":"Chang","year":"2002","journal-title":"Free Radic Biol Med"},{"key":"10.1378\/chest.09-0493_bib29","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s10753-006-8965-3","article-title":"Increased oxidative stress and altered levels of antioxidants in chronic obstructive pulmonary disease","volume":"29","author":"Nadeem","year":"2005","journal-title":"Inflammation"},{"key":"10.1378\/chest.09-0493_bib30","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1164\/rccm.200502-180OC","article-title":"Correlation of systemic superoxide dismutase deficiency to airflow obstruction in asthma","volume":"172","author":"Comhair","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.09-0493_bib31","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.freeradbiomed.2006.12.005","article-title":"Alternate day calorie restriction improves clinical findings and reduces markers of oxidative stress and inflammation in overweight adults with moderate asthma","volume":"42","author":"Johnson","year":"2007","journal-title":"Free Radic Biol Med"},{"key":"10.1378\/chest.09-0493_bib32","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.jaci.2003.10.046","article-title":"Leukotrienes and 8-isoprostane in exhaled breath condensate of children with stable and unstable asthma","volume":"113","author":"Zanconato","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1378\/chest.09-0493_bib33","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1136\/thorax.57.10.889","article-title":"Dose-dependent onset and cessation of action of inhaled budesonide on exhaled nitric oxide and symptoms in mild asthma","volume":"57","author":"Kharitonov","year":"2002","journal-title":"Thorax"},{"key":"10.1378\/chest.09-0493_bib34","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1164\/rccm.200405-611PP","article-title":"Diet and asthma","volume":"170","author":"McKeever","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.09-0493_bib35","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1081\/JAS-200044774","article-title":"Increased oxidative stress in acute exacerbations of asthma","volume":"42","author":"Nadeem","year":"2005","journal-title":"J Asthma"},{"key":"10.1378\/chest.09-0493_bib36","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1155\/2007\/342618","article-title":"Symposium on obesity and asthma, November 2, 2006","volume":"14","author":"Boulet","year":"2007","journal-title":"Can Respir J"},{"key":"10.1378\/chest.09-0493_bib37","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1080\/02770900701840261","article-title":"The value of sputum 8-isoprostane in detecting oxidative stress in mild asthma","volume":"45","author":"Louhelainen","year":"2008","journal-title":"J Asthma"},{"key":"10.1378\/chest.09-0493_bib38","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1038\/oby.2008.280","article-title":"Fat infiltration in muscle: new evidence for familial clustering and associations with diabetes","volume":"16","author":"Miljkovic-Gacic","year":"2008","journal-title":"Obesity (Silver Spring)"},{"key":"10.1378\/chest.09-0493_bib39","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1042\/cs0810249","article-title":"Muscle composition in relation to age and sex","volume":"81","author":"Forsberg","year":"1991","journal-title":"Clin Sci (Lond)"},{"key":"10.1378\/chest.09-0493_bib40","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1183\/09031936.00112407","article-title":"The effect of adiposity measured by dual-energy x-ray absorptiometry on lung function","volume":"32","author":"Sutherland","year":"2008","journal-title":"Eur Respir J"},{"key":"10.1378\/chest.09-0493_bib41","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.jaci.2005.02.033","article-title":"Does obesity weigh heavily on the health of the human airway?","volume":"115","author":"Sood","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.1378\/chest.09-0493_bib42","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1136\/thorax.58.12.1036","article-title":"Association of body mass with pulmonary function in the Childhood Asthma Management Program (CAMP)","volume":"58","author":"Tantisira","year":"2003","journal-title":"Thorax"},{"key":"10.1378\/chest.09-0493_bib43","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1503\/cmaj.081332","article-title":"Overdiagnosis of asthma in obese and non-obese adults","volume":"179","author":"Aaron","year":"2008","journal-title":"CMAJ"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369209606048?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369209606048?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T07:01:08Z","timestamp":1558422068000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369209606048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,10]]}},"alternative-id":["S0012369209606048"],"URL":"https:\/\/doi.org\/10.1378\/chest.09-0493","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[2009,10]]}}}