{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T16:16:16Z","timestamp":1782836176097,"version":"3.54.5"},"reference-count":40,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chest"],"published-print":{"date-parts":[[2009,11]]},"DOI":"10.1378\/chest.09-0604","type":"journal-article","created":{"date-parts":[[2009,7,18]],"date-time":"2009-07-18T01:45:26Z","timestamp":1247881526000},"page":"1301-1307","source":"Crossref","is-referenced-by-count":56,"title":["Changes in Exhaled Nitric Oxide Related to Estrogen and Progesterone During the Menstrual Cycle"],"prefix":"10.1016","volume":"136","author":[{"given":"Piush J.","family":"Mandhane","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven E.","family":"Hanna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark D.","family":"Inman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne M.","family":"Duncan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justina M.","family":"Greene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm R.","family":"Sears","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1378\/chest.09-0604_bib1","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1136\/thx.2004.033928","article-title":"Relation between phase of the menstrual cycle and asthma presentations in the emergency department","volume":"60","author":"Brenner","year":"2005","journal-title":"Thorax"},{"key":"10.1378\/chest.09-0604_bib2","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1164\/ajrccm.155.4.9105066","article-title":"Modulation of airway reactivity and peak flow variability in asthmatics receiving the oral contraceptive pill","volume":"155","author":"Tan","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.09-0604_bib3","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/j.1365-2222.1995.tb01078.x","article-title":"Influence of the menstrual cycle on skin-prick test reactions to histamine, morphine and allergen","volume":"25","author":"Kalogeromitros","year":"1995","journal-title":"Clin Exp Allergy"},{"key":"10.1378\/chest.09-0604_bib4","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.jaci.2006.02.004","article-title":"Endogenous and exogenous sex steroid hormones and asthma and wheeze in young women","volume":"117","author":"Salam","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1378\/chest.09-0604_bib5","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/S0140-6736(88)92837-1","article-title":"Severe premenstrual exacerbations of asthma: effect of intramuscular progesterone","volume":"2","author":"Beynon","year":"1988","journal-title":"Lancet"},{"key":"10.1378\/chest.09-0604_bib6","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1378\/chest.116.1.252","article-title":"A case of menstruation-associated asthma: treatment with oral contraceptives","volume":"116","author":"Matsuo","year":"1999","journal-title":"Chest"},{"key":"10.1378\/chest.09-0604_bib7","first-page":"197","article-title":"Premenstrual asthma: report of a case with hormonal studies","volume":"31","author":"Lam","year":"1998","journal-title":"J Microbiol Immunol Infect"},{"key":"10.1378\/chest.09-0604_bib8","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1378\/chest.106.1.318","article-title":"Should supplemental estrogens be used as steroid-sparing agents in asthmatic women?","volume":"106","author":"Myers","year":"1994","journal-title":"Chest"},{"key":"10.1378\/chest.09-0604_bib9","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/j.1875-9114.1997.tb03703.x","article-title":"Premenstrual asthma: the effect of estrogen on symptoms, pulmonary function, and \u03b22-receptors","volume":"17","author":"Chandler","year":"1997","journal-title":"Pharmacotherapy"},{"key":"10.1378\/chest.09-0604_bib10","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1165\/rcmb.2004-0331OC","article-title":"Estrogen reduces carbachol-induced constriction of asthmatic airways by stimulating large-conductance voltage and calcium-dependent potassium channels","volume":"32","author":"Dimitropoulou","year":"2005","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1378\/chest.09-0604_bib11","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1164\/rccm.200509-1493OC","article-title":"Spontaneous airway hyperresponsiveness in estrogen receptor-\u03b1-deficient mice","volume":"175","author":"Carey","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.09-0604_bib12","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1046\/j.1365-2222.2003.01743.x","article-title":"Progesterone increases airway eosinophilia and hyper-responsiveness in a murine model of allergic asthma","volume":"33","author":"Hellings","year":"2003","journal-title":"Clin Exp Allergy"},{"key":"10.1378\/chest.09-0604_bib13","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1183\/09031936.96.09040687","article-title":"Variations in the prevalence of respiratory symptoms, self-reported asthma attacks, and use of asthma medication in the European Community Respiratory Health Survey (ECRHS)","volume":"9","author":"European Community Respiratory Health Survey","year":"1996","journal-title":"Eur Respir J"},{"key":"10.1378\/chest.09-0604_bib14","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1034\/j.1399-3003.1999.14d29.x","article-title":"Development and validation of a questionnaire to measure asthma control","volume":"14","author":"Juniper","year":"1999","journal-title":"Eur Respir J"},{"key":"10.1378\/chest.09-0604_bib15","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1053\/rmed.2001.1034","article-title":"Measuring asthma control in group studies: do we need airway calibre and rescue \u03b22-agonist use?","volume":"95","author":"Juniper","year":"2001","journal-title":"Respir Med"},{"key":"10.1378\/chest.09-0604_bib16","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1164\/ajrccm.152.3.7663792","article-title":"Standardization of spirometry: 1994 update","volume":"152","author":"American Thoracic Society","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.09-0604_bib17","first-page":"169","article-title":"NAEPP updates guidelines for the diagnosis and management of asthma","volume":"68","author":"Ressel","year":"2003","journal-title":"Am Fam Physician"},{"key":"10.1378\/chest.09-0604_bib18","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1046\/j.1365-2362.1996.163311.x","article-title":"The effect of the menstrual cycle on exhaled nitric oxide and urinary nitrate concentration","volume":"26","author":"Morris","year":"1996","journal-title":"Eur J Clin Invest"},{"key":"10.1378\/chest.09-0604_bib19","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/0024-3205(95)02311-9","article-title":"Sex differences in concentrations of exhaled nitric oxide and plasma nitrate","volume":"58","author":"Jilma","year":"1996","journal-title":"Life Sci"},{"key":"10.1378\/chest.09-0604_bib20","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1136\/hrt.72.3.243","article-title":"Peak expiratory nitric oxide differences in men and women: relation to the menstrual cycle","volume":"72","author":"Kharitonov","year":"1994","journal-title":"Br Heart J"},{"key":"10.1378\/chest.09-0604_bib21","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1081\/JAS-120004921","article-title":"Airway inflammation in premenstrual asthma","volume":"39","author":"Oguzulgen","year":"2002","journal-title":"J Asthma"},{"key":"10.1378\/chest.09-0604_bib22","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0002-9343(00)00615-X","article-title":"Asthma in pregnancy","volume":"109","author":"Tan","year":"2000","journal-title":"Am J Med"},{"key":"10.1378\/chest.09-0604_bib23","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S1081-1206(10)62082-0","article-title":"Variables affecting asthma course during pregnancy","volume":"89","author":"Kircher","year":"2002","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1378\/chest.09-0604_bib24","first-page":"197","article-title":"Is the menstrual cycle affecting the skin prick test reactivity?","volume":"22","author":"Kirmaz","year":"2004","journal-title":"Asian Pac J Allergy Immunol"},{"key":"10.1378\/chest.09-0604_bib25","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1111\/j.1398-9995.2008.01880.x","article-title":"Gender difference, sex hormones, and immediate type hypersensitivity reactions","volume":"63","author":"Chen","year":"2008","journal-title":"Allergy"},{"key":"10.1378\/chest.09-0604_bib26","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/jlb.59.3.442","article-title":"Progesterone inhibits inducible nitric oxide synthase gene expression and nitric oxide production in murine macrophages","volume":"59","author":"Miller","year":"1996","journal-title":"J Leukoc Biol"},{"key":"10.1378\/chest.09-0604_bib27","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0165-0378(97)00060-0","article-title":"Female steroid hormones regulate production of pro-inflammatory molecules in uterine leukocytes","volume":"35","author":"Hunt","year":"1997","journal-title":"J Reprod Immunol"},{"key":"10.1378\/chest.09-0604_bib28","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/S0006-291X(03)00477-7","article-title":"17 beta-estradiol increases inducible nitric oxide synthase expression in macrophages","volume":"303","author":"You","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1378\/chest.09-0604_bib29","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1681\/ASN.V881240","article-title":"Sex hormones and renal nitric oxide synthases","volume":"8","author":"Neugarten","year":"1997","journal-title":"J Am Soc Nephrol"},{"key":"10.1378\/chest.09-0604_bib30","first-page":"2226","article-title":"Endometrial and myometrial expression of nitric oxide synthase isoforms in pre- and postmenopausal women","volume":"84","author":"Khorram","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1378\/chest.09-0604_bib31","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1677\/joe.0.156R001","article-title":"Expression of oestrogen receptor alpha and beta in rat heart: role of local oestrogen synthesis","volume":"156","author":"Grohe","year":"1998","journal-title":"J Endocrinol"},{"key":"10.1378\/chest.09-0604_bib32","first-page":"H853","article-title":"17\u03b2-estradiol reduces vasoconstriction in endothelium-denuded rat aortas through inducible NOS","volume":"274","author":"Binko","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1378\/chest.09-0604_bib33","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1038\/sj.bjp.0701715","article-title":"Effect of 17\u03b2-oestradiol on cytokine-induced nitric oxide production in rat isolated aorta","volume":"123","author":"Kauser","year":"1998","journal-title":"Br J Pharmacol"},{"key":"10.1378\/chest.09-0604_bib34","doi-asserted-by":"crossref","first-page":"C337","DOI":"10.1152\/ajpcell.1999.276.2.C337","article-title":"Estrogen modulates paracellular permeability of human endothelial cells by eNOS- and iNOS-related mechanisms","volume":"276","author":"Cho","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1378\/chest.09-0604_bib35","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/sj.jcbfm.9600194","article-title":"Inducible nitric oxide synthase contributes to gender differences in ischemic brain injury","volume":"26","author":"Park","year":"2006","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1378\/chest.09-0604_bib36","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1080\/02770900802207279","article-title":"Premenstrual asthma: prevalence, cycle-to-cycle variability and relationship to oral contraceptive use and menstrual symptoms","volume":"45","author":"Murphy","year":"2008","journal-title":"J Asthma"},{"key":"10.1378\/chest.09-0604_bib37","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1136\/thx.39.11.833","article-title":"Premenstrual exacerbation of asthma","volume":"39","author":"Gibbs","year":"1984","journal-title":"Thorax"},{"key":"10.1378\/chest.09-0604_bib38","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S1081-1206(10)62820-7","article-title":"Exacerbation of premenstrual asthma caused by an oral contraceptive","volume":"81","author":"Derimanov","year":"1998","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1378\/chest.09-0604_bib39","first-page":"A37","article-title":"Airway inflammation in premenstrual asthma [abstract]","volume":"165","author":"Gibson","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.09-0604_bib40","first-page":"S1","article-title":"Canadian asthma consensus report, 1999: Canadian Asthma Consensus Group","volume":"161","author":"Boulet","year":"1999","journal-title":"Can Med Assoc J"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369209606863?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369209606863?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T08:54:29Z","timestamp":1710492869000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369209606863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["S0012369209606863"],"URL":"https:\/\/doi.org\/10.1378\/chest.09-0604","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[2009,11]]}}}