{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T07:04:52Z","timestamp":1789542292376,"version":"build-2803163510"},"reference-count":35,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal.chestnet.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chest"],"published-print":{"date-parts":[[2010,3]]},"DOI":"10.1378\/chest.09-0667","type":"journal-article","created":{"date-parts":[[2009,10,16]],"date-time":"2009-10-16T20:58:50Z","timestamp":1255726730000},"page":"658-664","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"title":["Determinants of Exhaled Nitric Oxide in Chronic Rhinosinusitis"],"prefix":"10.1016","volume":"137","author":[{"given":"Giuseppe","family":"Guida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Rolla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iuliana","family":"Badiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Marsico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Pizzimenti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Bommarito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"De Stefani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Usai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Bugiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei","family":"Malinovschi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Bucca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Heffler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl 57","key":"10.1378\/chest.09-0667_bib1","first-page":"13","article-title":"Epidemiological evidence of the occurrence of rhinitis and sinusitis in asthmatics","volume":"54","author":"Annesi-Maesano","year":"1999","journal-title":"Allergy"},{"issue":"5","key":"10.1378\/chest.09-0667_bib2","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0091-6749(74)90111-0","article-title":"Maxillary sinusitis and bronchial asthma: correlation of roentgenograms, cultures, and thermograms","volume":"53","author":"Berman","year":"1974","journal-title":"J Allergy Clin Immunol"},{"issue":"5","key":"10.1378\/chest.09-0667_bib3","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/0091-6749(78)90052-0","article-title":"Sinus disease in children with respiratory allergy","volume":"61","author":"Rachelefsky","year":"1978","journal-title":"J Allergy Clin Immunol"},{"issue":"5","key":"10.1378\/chest.09-0667_bib4","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/0091-6749(94)90146-5","article-title":"Screening for sinus disease in patients with asthma: a computed tomography-controlled comparison of A-mode ultrasonography and standard radiography","volume":"94","author":"Pfister","year":"1994","journal-title":"J Allergy Clin Immunol"},{"issue":"4","key":"10.1378\/chest.09-0667_bib5","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1067\/mai.2002.122458","article-title":"Chronic sinusitis in severe asthma is related to sputum eosinophilia","volume":"109","author":"ten Brinke","year":"2002","journal-title":"J Allergy Clin Immunol"},{"issue":"5","key":"10.1378\/chest.09-0667_bib6","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1378\/chest.06-2618","article-title":"Diagnostic classification of persistent rhinitis and its relationship to exhaled nitric oxide and asthma: a clinical study of a consecutive series of patients","volume":"131","author":"Rolla","year":"2007","journal-title":"Chest"},{"issue":"3","key":"10.1378\/chest.09-0667_bib7","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1378\/chest.123.3.751","article-title":"Prospective evaluation of the validity of exhaled nitric oxide for the diagnosis of asthma","volume":"123","author":"Dupont","year":"2003","journal-title":"Chest"},{"issue":"11","key":"10.1378\/chest.09-0667_bib8","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1016\/j.rmed.2006.02.019","article-title":"Exhaled nitric oxide as a diagnostic test for asthma in rhinitic patients with asthmatic symptoms","volume":"100","author":"Heffler","year":"2006","journal-title":"Respir Med"},{"issue":"9","key":"10.1378\/chest.09-0667_bib9","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1136\/thx.2005.056093","article-title":"Exhaled nitric oxide measurements: clinical application and interpretation","volume":"61","author":"Taylor","year":"2006","journal-title":"Thorax"},{"issue":"5","key":"10.1378\/chest.09-0667_bib10","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1378\/chest.130.5.1319","article-title":"Height, age, and atopy are associated with fraction of exhaled nitric oxide in a large adult general population sample","volume":"130","author":"Olin","year":"2006","journal-title":"Chest"},{"issue":"3","key":"10.1378\/chest.09-0667_bib11","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1164\/rccm.200609-1346OC","article-title":"Reference ranges for exhaled nitric oxide derived from a random community survey of adults","volume":"176","author":"Travers","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"issue":"7","key":"10.1378\/chest.09-0667_bib12","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.rmed.2008.02.012","article-title":"Exhaled nitric oxide: independent effects of atopy, smoking, respiratory tract infection, gender and height","volume":"102","author":"Dressel","year":"2008","journal-title":"Respir Med"},{"issue":"4","key":"10.1378\/chest.09-0667_bib13","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1034\/j.1399-3003.1999.14d28.x","article-title":"Influence of atopy on exhaled nitric oxide in patients with stable asthma and rhinitis","volume":"14","author":"Gratziou","year":"1999","journal-title":"Eur Respir J"},{"issue":"11","key":"10.1378\/chest.09-0667_bib14","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1046\/j.1365-2222.2003.01800.x","article-title":"Interrelationships among asthma, atopy, rhinitis and exhaled nitric oxide in a population-based sample of children","volume":"33","author":"Jouaville","year":"2003","journal-title":"Clin Exp Allergy"},{"issue":"20","key":"10.1378\/chest.09-0667_bib15","first-page":"1","article-title":"European position paper on rhinosinusitis and nasal polyps 2007","author":"Fokkens","year":"2007","journal-title":"Rhinol Suppl"},{"issue":"11","key":"10.1378\/chest.09-0667_bib16","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1111\/j.1398-9995.2006.01225.x","article-title":"Differentiation of chronic sinus diseases by measurement of inflammatory mediators","volume":"61","author":"Van Zele","year":"2006","journal-title":"Allergy"},{"issue":"9","key":"10.1378\/chest.09-0667_bib17","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1111\/j.1365-2222.2005.02314.x","article-title":"The use of exhaled nitric oxide concentration to identify eosinophilic airway inflammation: an observational study in adults with asthma","volume":"35","author":"Berry","year":"2005","journal-title":"Clin Exp Allergy"},{"issue":"1","key":"10.1378\/chest.09-0667_bib18","first-page":"225","article-title":"Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, November 1986","volume":"136","year":"1987","journal-title":"Am Rev Respir Dis"},{"issue":"2","key":"10.1378\/chest.09-0667_bib19","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1183\/09031936.93.06020155","article-title":"Standardised lung function testing","volume":"6","author":"Gibson","year":"1993","journal-title":"Eur Respir J"},{"issue":"8","key":"10.1378\/chest.09-0667_bib20","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1164\/rccm.200406-710ST","article-title":"ATS\/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005","volume":"171","author":"American Thoracic Society","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"issue":"2 Pt 1","key":"10.1378\/chest.09-0667_bib21","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1164\/ajrccm.154.2.8756799","article-title":"Indices of airway inflammation in induced sputum: reproducibility and validity of cell and fluid-phase measurements","volume":"154","author":"Pizzichini","year":"1996","journal-title":"Am J Respir Crit Care Med"},{"issue":"5","key":"10.1378\/chest.09-0667_bib22","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.jaci.2007.02.042","article-title":"Noneosinophilic asthma: a distinct clinical and pathologic phenotype","volume":"119","author":"Haldar","year":"2007","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"10.1378\/chest.09-0667_bib23","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S0194-5998(99)70127-0","article-title":"Long-term impact of functional endoscopic sinus surgery on asthma","volume":"121","author":"Senior","year":"1999","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"5","key":"10.1378\/chest.09-0667_bib24","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.jaci.2003.08.009","article-title":"Features of airway remodeling and eosinophilic inflammation in chronic rhinosinusitis: is the histopathology similar to asthma?","volume":"112","author":"Ponikau","year":"2003","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"10.1378\/chest.09-0667_bib25","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1177\/194589240401800105","article-title":"Objective assessment of lower airway involvement in chronic rhinosinusitis","volume":"18","author":"Ragab","year":"2004","journal-title":"Am J Rhinol"},{"issue":"5","key":"10.1378\/chest.09-0667_bib26","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1067\/mai.2003.1487","article-title":"Aspirin-induced asthma: advances in pathogenesis, diagnosis, and management","volume":"111","author":"Szczeklik","year":"2003","journal-title":"J Allergy Clin Immunol"},{"issue":"1 suppl","key":"10.1378\/chest.09-0667_bib27","doi-asserted-by":"crossref","first-page":"116S","DOI":"10.1378\/chest.129.1_suppl.116S","article-title":"Chronic cough due to nonasthmatic eosinophilic bronchitis: ACCP evidence-based clinical practice guidelines","volume":"129","author":"Brightling","year":"2006","journal-title":"Chest"},{"issue":"9171","key":"10.1378\/chest.09-0667_bib28","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1016\/S0140-6736(99)01813-9","article-title":"Non-eosinophilic corticosteroid unresponsive asthma","volume":"353","author":"Pavord","year":"1999","journal-title":"Lancet"},{"issue":"3","key":"10.1378\/chest.09-0667_bib29","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1183\/09031936.02.00285302","article-title":"Exhaled NO and assessment of anti-inflammatory effects of inhaled steroid: dose-response relationship","volume":"20","author":"Jones","year":"2002","journal-title":"Eur Respir J"},{"issue":"4","key":"10.1378\/chest.09-0667_bib30","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1164\/rccm.200411-1498OC","article-title":"Exhaled nitric oxide: a predictor of steroid response","volume":"172","author":"Smith","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"issue":"1 pt 1","key":"10.1378\/chest.09-0667_bib31","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/S0091-6749(95)70152-4","article-title":"Extrathoracic and intrathoracic airway responsiveness in sinusitis","volume":"95","author":"Bucca","year":"1995","journal-title":"J Allergy Clin Immunol"},{"issue":"1 suppl","key":"10.1378\/chest.09-0667_bib32","doi-asserted-by":"crossref","first-page":"63S","DOI":"10.1378\/chest.129.1_suppl.63S","article-title":"Chronic upper airway cough syndrome secondary to rhinosinus diseases (previously referred to as postnasal drip syndrome): ACCP evidence-based clinical practice guidelines","volume":"129","author":"Pratter","year":"2006","journal-title":"Chest"},{"issue":"3 pt 1","key":"10.1378\/chest.09-0667_bib33","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/S0091-6749(99)70320-9","article-title":"Allergic rhinobronchitis: the asthma-allergic rhinitis link","volume":"104","author":"Simons","year":"1999","journal-title":"J Allergy Clin Immunol"},{"issue":"8","key":"10.1378\/chest.09-0667_bib34","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/S0954-6111(99)90154-3","article-title":"Exhaled nitric oxide and its relationship to airway responsiveness and atopy in asthma","volume":"93","author":"L\u00fadv\u00edksd\u00f3ttir","year":"1999","journal-title":"Respir Med"},{"issue":"1","key":"10.1378\/chest.09-0667_bib35","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1398-9995.2008.01835.x","article-title":"Both allergic and nonallergic asthma are associated with increased FE(NO) levels, but only in never-smokers","volume":"64","author":"Malinovschi","year":"2009","journal-title":"Allergy"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369210601456?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369210601456?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T06:18:55Z","timestamp":1757917135000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369210601456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["S0012369210601456"],"URL":"https:\/\/doi.org\/10.1378\/chest.09-0667","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[2010,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Determinants of Exhaled Nitric Oxide in Chronic Rhinosinusitis","name":"articletitle","label":"Article Title"},{"value":"Chest","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1378\/chest.09-0667","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 The American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}