{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T20:32:14Z","timestamp":1790973134014,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,12,7]],"date-time":"2015-12-07T00:00:00Z","timestamp":1449446400000},"content-version":"vor","delay-in-days":2076,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal.chestnet.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chest"],"published-print":{"date-parts":[[2010,4]]},"DOI":"10.1378\/chest.09-1839","type":"journal-article","created":{"date-parts":[[2010,2,5]],"date-time":"2010-02-05T21:11:08Z","timestamp":1265404268000},"page":"797-804","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"title":["Airway Wall Expression of OX40\/OX40L and Interleukin-4 in Asthma"],"prefix":"10.1016","volume":"137","author":[{"given":"Salman","family":"Siddiqui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay","family":"Mistry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Doe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"Stinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martyn","family":"Foster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Brightling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1378\/chest.09-1839_bib1","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1067\/mai.2002.129698","article-title":"Th2 cytokine expression by bronchoalveolar lavage fluid T lymphocytes and bronchial submucosa is a feature of asthma and eosinophilic bronchitis","volume":"110","author":"Brightling","year":"2002","journal-title":"J Allergy Clin Immunol"},{"issue":"4","key":"10.1378\/chest.09-1839_bib2","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1183\/09031936.00094506","article-title":"Master switches of T-cell activation and differentiation","volume":"29","author":"Beier","year":"2007","journal-title":"Eur Respir J"},{"issue":"12","key":"10.1378\/chest.09-1839_bib3","doi-asserted-by":"crossref","first-page":"6510","DOI":"10.4049\/jimmunol.161.12.6510","article-title":"Ox-40 ligand: a potent costimulatory molecule for sustaining primary CD4 T cell responses","volume":"161","author":"Gramaglia","year":"1998","journal-title":"J Immunol"},{"issue":"2","key":"10.1378\/chest.09-1839_bib4","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1084\/jem.191.2.201","article-title":"Role of OX40 signals in coordinating CD4 T cell selection, migration, and cytokine differentiation in T helper (Th)1 and Th2 cells","volume":"191","author":"Lane","year":"2000","journal-title":"J Exp Med"},{"issue":"3","key":"10.1378\/chest.09-1839_bib5","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1084\/jem.193.3.387","article-title":"Development of allergic inflammation in a murine model of asthma is dependent on the costimulatory receptor OX40","volume":"193","author":"Jember","year":"2001","journal-title":"J Exp Med"},{"issue":"6","key":"10.1378\/chest.09-1839_bib6","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1111\/j.1365-2222.2009.03241.x","article-title":"Thymic stromal lymphopoietin, OX40-ligand, and interleukin-25 in allergic responses","volume":"39","author":"Wang","year":"2009","journal-title":"Clin Exp Allergy"},{"issue":"2","key":"10.1378\/chest.09-1839_bib7","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.jaci.2007.06.004","article-title":"Thymic stromal lymphopoietin and OX40 ligand pathway in the initiation of dendritic cell-mediated allergic inflammation","volume":"120","author":"Liu","year":"2007","journal-title":"J Allergy Clin Immunol"},{"issue":"12","key":"10.1378\/chest.09-1839_bib8","doi-asserted-by":"crossref","first-page":"3868","DOI":"10.1172\/JCI33559","article-title":"In vivo blockade of OX40 ligand inhibits thymic stromal lymphopoietin driven atopic inflammation","volume":"117","author":"Seshasayee","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1378\/chest.09-1839_bib10","series-title":"Histamine and Methacholine Inhalation Tests: A Laboratory Tidal Breathing Protocol","author":"Juniper","year":"1994"},{"issue":"6","key":"10.1378\/chest.09-1839_bib11","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1136\/thx.52.6.498","article-title":"The use of induced sputum to investigate airway inflammation","volume":"52","author":"Pavord","year":"1997","journal-title":"Thorax"},{"issue":"suppl 1","key":"10.1378\/chest.09-1839_bib12","first-page":"i1","article-title":"British Thoracic Society guidelines on diagnostic flexible bronchoscopy","volume":"56","author":"British Thoracic Society","year":"2001","journal-title":"Thorax"},{"issue":"5","key":"10.1378\/chest.09-1839_bib13","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3109\/10520299309105629","article-title":"Immunohistochemistry on resin sections: a comparison of resin embedding techniques for small mucosal biopsies","volume":"68","author":"Britten","year":"1993","journal-title":"Biotech Histochem"},{"issue":"22","key":"10.1378\/chest.09-1839_bib14","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1056\/NEJMoa012705","article-title":"Mast-cell infiltration of airway smooth muscle in asthma","volume":"346","author":"Brightling","year":"2002","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1378\/chest.09-1839_bib15","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.jaci.2008.10.048","article-title":"Fibrocyte localization to the airway smooth muscle is a feature of asthma","volume":"123","author":"Saunders","year":"2009","journal-title":"J Allergy Clin Immunol"},{"issue":"10","key":"10.1378\/chest.09-1839_bib16","doi-asserted-by":"crossref","first-page":"2874","DOI":"10.1002\/1521-4141(2002010)32:10<2874::AID-IMMU2874>3.0.CO;2-4","article-title":"Costimulatory molecule OX40L is critical for both Th1 and Th2 responses in allergic inflammation","volume":"32","author":"Arestides","year":"2002","journal-title":"Eur J Immunol"},{"issue":"4","key":"10.1378\/chest.09-1839_bib17","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1002\/eji.200323455","article-title":"Critical role for OX40 ligand in the development of pathogenic Th2 cells in a murine model of asthma","volume":"33","author":"Hoshino","year":"2003","journal-title":"Eur J Immunol"},{"issue":"suppl 1","key":"10.1378\/chest.09-1839_bib18","doi-asserted-by":"crossref","first-page":"116S","DOI":"10.1378\/chest.129.1_suppl.116S","article-title":"Chronic cough due to nonasthmatic eosinophilic bronchitis: ACCP evidence-based clinical practice guidelines","volume":"129","author":"Brightling","year":"2006","journal-title":"Chest"},{"issue":"2","key":"10.1378\/chest.09-1839_bib19","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1136\/thorax.57.2.178","article-title":"Eosinophilic bronchitis: clinical manifestations and implications for treatment","volume":"57","author":"Gibson","year":"2002","journal-title":"Thorax"},{"issue":"9248","key":"10.1378\/chest.09-1839_bib20","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1016\/S0140-6736(00)03496-6","article-title":"Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response","volume":"356","author":"Leckie","year":"2000","journal-title":"Lancet"},{"issue":"10","key":"10.1378\/chest.09-1839_bib21","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1056\/NEJMoa0808991","article-title":"Mepolizumab and exacerbations of refractory eosinophilic asthma","volume":"360","author":"Haldar","year":"2009","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1378\/chest.09-1839_bib22","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.4049\/jimmunol.0802773","article-title":"Asthma-related environmental fungus, Alternaria, activates dendritic cells and produces potent Th2 adjuvant activity","volume":"182","author":"Kobayashi","year":"2009","journal-title":"J Immunol"},{"issue":"12","key":"10.1378\/chest.09-1839_bib23","doi-asserted-by":"crossref","first-page":"8650","DOI":"10.4049\/jimmunol.181.12.8650","article-title":"Antagonism of airway tolerance by endotoxin\/lipopolysaccharide through promoting OX40L and suppressing antigen-specific Foxp31 T regulatory cells","volume":"181","author":"Duan","year":"2008","journal-title":"J Immunol"},{"issue":"1","key":"10.1378\/chest.09-1839_bib24","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1164\/rccm.200805-737OC","article-title":"Randomized controlled trial of oral antifungal treatment for severe asthma with fungal sensitization: The Fungal Asthma Sensitization Trial (FAST) study","volume":"179","author":"Denning","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"10.1378\/chest.09-1839_bib25","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1136\/thx.2006.061358","article-title":"Innate immune activation in neutrophilic asthma and bronchiectasis","volume":"62","author":"Simpson","year":"2007","journal-title":"Thorax"},{"issue":"2","key":"10.1378\/chest.09-1839_bib26","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.jaci.2004.11.004","article-title":"CD40 and OX40 ligand are increased on stimulated asthmatic airway smooth muscle","volume":"115","author":"Burgess","year":"2005","journal-title":"J Allergy Clin Immunol"},{"issue":"4","key":"10.1378\/chest.09-1839_bib27","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.jaci.2003.12.311","article-title":"Detection and characterization of OX40 ligand expression in human airway smooth muscle cells: a possible role in asthma?","volume":"113","author":"Burgess","year":"2004","journal-title":"J Allergy Clin Immunol"},{"issue":"6","key":"10.1378\/chest.09-1839_bib28","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1183\/09031936.00162506","article-title":"Inflammatory cell microlocalisation and airway dysfunction: cause and effect?","volume":"30","author":"Siddiqui","year":"2007","journal-title":"Eur Respir J"},{"issue":"12","key":"10.1378\/chest.09-1839_bib29","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1136\/thx.2005.045260","article-title":"Tumour necrosis factor (TNFalpha) as a novel therapeutic target in symptomatic corticosteroid dependent asthma","volume":"60","author":"Howarth","year":"2005","journal-title":"Thorax"},{"issue":"2","key":"10.1378\/chest.09-1839_bib30","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1084\/jem.20021937","article-title":"OX40 (CD134) controls memory T helper 2 cells that drive lung inflammation","volume":"198","author":"Salek-Ardakani","year":"2003","journal-title":"J Exp Med"},{"issue":"6","key":"10.1378\/chest.09-1839_bib31","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1183\/09031936.99.13612539","article-title":"Mucosal inflammation in severe glucocorticoid-dependent asthma","volume":"13","author":"Vrugt","year":"1999","journal-title":"Eur Respir J"},{"issue":"5","key":"10.1378\/chest.09-1839_bib32","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/j.jaci.2004.08.032","article-title":"Sputum and bronchial submucosal IL-13 expression in asthma and eosinophilic bronchitis","volume":"114","author":"Berry","year":"2004","journal-title":"J Allergy Clin Immunol"},{"issue":"3","key":"10.1378\/chest.09-1839_bib33","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.jaci.2008.01.005","article-title":"Increased sputum and bronchial biopsy IL-13 expression in severe asthma","volume":"121","author":"Saha","year":"2008","journal-title":"J Allergy Clin Immunol"},{"issue":"6","key":"10.1378\/chest.09-1839_bib34","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1067\/mai.2001.115624","article-title":"Efficacy of soluble IL-4 receptor for the treatment of adults with asthma","volume":"107","author":"Borish","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"10.1378\/chest.09-1839_bib35","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.0105-2896.2004.00215.x","article-title":"Interleukin-13 in asthma pathogenesis","volume":"202","author":"Wills-Karp","year":"2004","journal-title":"Immunol Rev"},{"issue":"9596","key":"10.1378\/chest.09-1839_bib36","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1016\/S0140-6736(07)61600-6","article-title":"Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies","volume":"370","author":"Wenzel","year":"2007","journal-title":"Lancet"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369210601833?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369210601833?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T06:17:34Z","timestamp":1757917054000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369210601833"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["S0012369210601833"],"URL":"https:\/\/doi.org\/10.1378\/chest.09-1839","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[2010,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Airway Wall Expression of OX40\/OX40L and Interleukin-4 in Asthma","name":"articletitle","label":"Article Title"},{"value":"Chest","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1378\/chest.09-1839","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 The American College of Chest Physicians. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}