{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:30:43Z","timestamp":1773282643614,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal.chestnet.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chest"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1378\/chest.09-2824","type":"journal-article","created":{"date-parts":[[2010,6,24]],"date-time":"2010-06-24T23:40:23Z","timestamp":1277422823000},"page":"1309-1315","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["Efficiency of Neural Drive During Exercise in Patients With COPD and Healthy Subjects"],"prefix":"10.1016","volume":"138","author":[{"given":"Yin-Yin","family":"Qin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joerg","family":"Steier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Jolley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Moxham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan-Shan","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan-Ming","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1378\/chest.09-2824_bib1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1513\/pats.200508-084SF","article-title":"Dynamic hyperinflation: is it worth measuring?","volume":"3","author":"Calverley","year":"2006","journal-title":"Proc Am Thorac Soc"},{"issue":"3","key":"10.1378\/chest.09-2824_bib2","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1164\/ajrccm.152.3.7663810","article-title":"Exhaustive treadmill exercise does not reduce twitch transdiaphragmatic pressure in patients with COPD","volume":"152","author":"Polkey","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"10.1378\/chest.09-2824_bib3","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1164\/ajrccm.161.1.9903010","article-title":"Diaphragmatic fatigue and high-intensity exercise in patients with chronic obstructive pulmonary disease","volume":"161","author":"Mador","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"issue":"2-3","key":"10.1378\/chest.09-2824_bib4","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.resp.2004.12.014","article-title":"Measurement of neural respiratory drive in patients with COPD","volume":"146","author":"Luo","year":"2005","journal-title":"Respir Physiol Neurobiol"},{"issue":"7","key":"10.1378\/chest.09-2824_bib5","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1164\/ajrccm.163.7.2007033","article-title":"Diaphragm activation during exercise in chronic obstructive pulmonary disease","volume":"163","author":"Sinderby","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"10.1378\/chest.09-2824_bib6","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1152\/jappl.1998.85.4.1322","article-title":"Influence of acute lung volume change on contractile properties of human diaphragm","volume":"85","author":"Polkey","year":"1998","journal-title":"J Appl Physiol"},{"issue":"3","key":"10.1378\/chest.09-2824_bib7","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1183\/09031936.00049907","article-title":"Neural respiratory drive during apnoeic events in obstructive sleep apnoea","volume":"31","author":"Luo","year":"2008","journal-title":"Eur Respir J"},{"issue":"2","key":"10.1378\/chest.09-2824_bib8","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1183\/09031936.00093408","article-title":"Neural respiratory drive in healthy subjects and in COPD","volume":"33","author":"Jolley","year":"2009","journal-title":"Eur Respir J"},{"issue":"1","key":"10.1378\/chest.09-2824_bib9","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1164\/ajrccm\/146.1.16","article-title":"Abdominal muscle use during breathing in patients with chronic airflow obstruction","volume":"146","author":"Ninane","year":"1992","journal-title":"Am Rev Respir Dis"},{"issue":"4","key":"10.1378\/chest.09-2824_bib10","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1164\/ajrccm.155.4.9105076","article-title":"Neural drive to the diaphragm in patients with severe COPD","volume":"155","author":"De Troyer","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"issue":"5","key":"10.1378\/chest.09-2824_bib11","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1152\/jappl.2001.90.5.1691","article-title":"Effect of diaphragm fatigue on neural respiratory drive","volume":"90","author":"Luo","year":"2001","journal-title":"J Appl Physiol"},{"issue":"6","key":"10.1378\/chest.09-2824_bib12","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1034\/j.1399-3003.2000.01510.x","article-title":"Effect of lung volume on the oesophageal diaphragm EMG assessed by magnetic phrenic nerve stimulation","volume":"15","author":"Luo","year":"2000","journal-title":"Eur Respir J"},{"issue":"5","key":"10.1378\/chest.09-2824_bib13","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1378\/chest.08-1695","article-title":"Distinguishing obstructive from central sleep apnea events: diaphragm electromyogram and esophageal pressure compared","volume":"135","author":"Luo","year":"2009","journal-title":"Chest"},{"issue":"2","key":"10.1378\/chest.09-2824_bib14","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1152\/jappl.1985.59.2.365","article-title":"Mechanical impedance as determinant of inspiratory neural drive during exercise in humans","volume":"59","author":"Hussain","year":"1985","journal-title":"J Appl Physiol"},{"issue":"4","key":"10.1378\/chest.09-2824_bib15","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1378\/chest.96.4.824","article-title":"Neural respiratory drive and neuromuscular coupling during CO2 rebreathing in patients with chronic interstitial lung disease","volume":"96","author":"Gorini","year":"1989","journal-title":"Chest"},{"issue":"5","key":"10.1378\/chest.09-2824_bib16","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1152\/jappl.2001.91.5.1913","article-title":"Volume displaced by diaphragm motion in emphysema","volume":"91","author":"Singh","year":"2001","journal-title":"J Appl Physiol"},{"issue":"8","key":"10.1378\/chest.09-2824_bib17","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1136\/thx.2008.109728","article-title":"Neural respiratory drive in obesity","volume":"64","author":"Steier","year":"2009","journal-title":"Thorax"},{"issue":"3","key":"10.1378\/chest.09-2824_bib18","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1164\/ajrccm.164.3.2009018","article-title":"Electrical activity of the diaphragm during pressure support ventilation in acute respiratory failure","volume":"164","author":"Beck","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"10.1378\/chest.09-2824_bib19","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1164\/rccm.166.4.518","article-title":"ATS\/ERS Statement on respiratory muscle testing","volume":"166","author":"American Thoracic Society\/European Respiratory Society","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"issue":"5 pt 1","key":"10.1378\/chest.09-2824_bib20","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1164\/ajrccm.160.5.9809068","article-title":"Quantification of the esophageal diaphragm electromyogram with magnetic phrenic nerve stimulation","volume":"160","author":"Luo","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"10.1378\/chest.09-2824_bib21","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1152\/jappl.1998.85.3.1123","article-title":"Effects of lung volume on diaphragm EMG signal strength during voluntary contractions","volume":"85","author":"Beck","year":"1998","journal-title":"J Appl Physiol"},{"issue":"2","key":"10.1378\/chest.09-2824_bib22","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1152\/jappl.1998.85.2.451","article-title":"Crural diaphragm activation during dynamic contractions at various inspiratory flow rates","volume":"85","author":"Beck","year":"1998","journal-title":"J Appl Physiol"},{"issue":"8","key":"10.1378\/chest.09-2824_bib23","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1042\/CS20070348","article-title":"Diaphragm electromyography using an oesophageal catheter: current concepts","volume":"115","author":"Luo","year":"2008","journal-title":"Clin Sci (Lond)"},{"issue":"7","key":"10.1378\/chest.09-2824_bib24","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.sleep.2008.06.012","article-title":"Neural drive during continuous positive airway pressure (CPAP) and pressure relief CPAP","volume":"10","author":"Luo","year":"2009","journal-title":"Sleep Med"},{"issue":"1","key":"10.1378\/chest.09-2824_bib25","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ejheart.2005.04.009","article-title":"Does symptom-limited cycle exercise cause low frequency diaphragm fatigue in patients with heart failure?","volume":"8","author":"Dayer","year":"2006","journal-title":"Eur J Heart Fail"},{"key":"10.1378\/chest.09-2824_bib26","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1113\/jphysiol.1993.sp019477","article-title":"Exercise-induced diaphragmatic fatigue in healthy humans","volume":"460","author":"Johnson","year":"1993","journal-title":"J Physiol"},{"issue":"3","key":"10.1378\/chest.09-2824_bib27","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.resp.2006.06.007","article-title":"Exercise-induced depression of the diaphragm motor evoked potential is not affected by non-invasive ventilation","volume":"155","author":"Dayer","year":"2007","journal-title":"Respir Physiol Neurobiol"},{"issue":"2","key":"10.1378\/chest.09-2824_bib28","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1164\/rccm.200210-1246OC","article-title":"Is weaning failure caused by low-frequency fatigue of the diaphragm?","volume":"167","author":"Laghi","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"10.1378\/chest.09-2824_bib29","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0034-5687(94)00073-9","article-title":"Respiratory failure due to altered central drive during inspiratory loading in rabbits","volume":"99","author":"Ferguson","year":"1995","journal-title":"Respir Physiol"},{"issue":"1","key":"10.1378\/chest.09-2824_bib30","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1152\/jappl.1996.81.1.238","article-title":"Temporal relationships of ventilatory failure, pump failure, and diaphragm fatigue","volume":"81","author":"Sassoon","year":"1996","journal-title":"J Appl Physiol"},{"key":"10.1378\/chest.09-2824_bib31","unstructured":"Luo YM, Li RF, Jolley C, et al. Neural respiratory drive in patients with COPD during exercise tests. Respiration. In press."},{"issue":"5","key":"10.1378\/chest.09-2824_bib32","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1164\/ajrccm.164.5.2012122","article-title":"Dynamic hyperinflation and exercise intolerance in chronic obstructive pulmonary disease","volume":"164","author":"O'Donnell","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"issue":"5","key":"10.1378\/chest.09-2824_bib33","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1164\/ajrccm\/148.5.1351","article-title":"Exertional breathlessness in patients with chronic airflow limitation. The role of lung hyperinflation","volume":"148","author":"O'Donnell","year":"1993","journal-title":"Am Rev Respir Dis"},{"issue":"5","key":"10.1378\/chest.09-2824_bib34","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1152\/jappl.2000.88.5.1859","article-title":"Respiratory sensation during chest wall restriction and dead space loading in exercising men","volume":"88","author":"O'Donnell","year":"2000","journal-title":"J Appl Physiol"},{"issue":"6","key":"10.1378\/chest.09-2824_bib35","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1164\/ajrccm\/145.6.1339","article-title":"Dyspnea and leg effort during incremental cycle ergometry","volume":"145","author":"Killian","year":"1992","journal-title":"Am Rev Respir Dis"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369210606381?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369210606381?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T06:20:27Z","timestamp":1757917227000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369210606381"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S0012369210606381"],"URL":"https:\/\/doi.org\/10.1378\/chest.09-2824","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficiency of Neural Drive During Exercise in Patients With COPD and Healthy Subjects","name":"articletitle","label":"Article Title"},{"value":"Chest","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1378\/chest.09-2824","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 The American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}