{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:47:45Z","timestamp":1791226065754,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal.chestnet.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chest"],"published-print":{"date-parts":[[2010,11]]},"DOI":"10.1378\/chest.09-2996","type":"journal-article","created":{"date-parts":[[2010,5,14]],"date-time":"2010-05-14T22:41:36Z","timestamp":1273876896000},"page":"1186-1195","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":183,"title":["Sputum Candida albicans Presages FEV1 Decline and Hospital-Treated Exacerbations in Cystic Fibrosis"],"prefix":"10.1016","volume":"138","author":[{"given":"Sanjay H.","family":"Chotirmall","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine","family":"O'Donoghue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cedric","family":"Gunaratnam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shane J.","family":"O'Neill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noel G.","family":"McElvaney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1378\/chest.09-2996_bib1","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1080\/13693780802609604","article-title":"Occurrence and relevance of filamentous fungi in respiratory secretions of patients with cystic fibrosis\u2014a review","volume":"47","author":"Pihet","year":"2009","journal-title":"Med Mycol"},{"issue":"1\u20132","key":"10.1378\/chest.09-2996_bib2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1046\/j.0933-7407.2001.00719.x","article-title":"Recovery of Candida dubliniensis from sputum of cystic fibrosis patients","volume":"45","author":"Peltroche-Llacsahuanga","year":"2002","journal-title":"Mycoses"},{"issue":"8","key":"10.1378\/chest.09-2996_bib3","first-page":"1035","article-title":"Aspergillus\/allergic bronchopulmonary aspergillosis in an Irish cystic fibrosis population: a diagnostically challenging entity","volume":"53","author":"Chotirmall","year":"2008","journal-title":"Respir Care"},{"key":"10.1378\/chest.09-2996_bib4","first-page":"A845","article-title":"Correlation between pulmonary function testing and high resolution computed tomography thorax scanning in cystic fibrosis patients with aspergillus positive sputum","volume":"175","author":"Chotirmall","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"10.1378\/chest.09-2996_bib5","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1183\/09031936.01.00068901","article-title":"Factors associated with poor pulmonary function: cross-sectional analysis of data from the ERCF. European Epidemiologic Registry of Cystic Fibrosis","volume":"18","author":"Navarro","year":"2001","journal-title":"Eur Respir J"},{"issue":"1","key":"10.1378\/chest.09-2996_bib6","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1378\/chest.09-1103","article-title":"The effect of chronic infection with Aspergillus fumigatus on lung function and hospitalization in patients with cystic fibrosis","volume":"137","author":"Amin","year":"2009","journal-title":"Chest"},{"issue":"1","key":"10.1378\/chest.09-2996_bib7","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jcf.2004.12.002","article-title":"Standards of care for patients with cystic fibrosis: a European consensus","volume":"4","author":"Kerem","year":"2005","journal-title":"J Cyst Fibros"},{"issue":"1\u20132","key":"10.1378\/chest.09-2996_bib8","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1046\/j.1439-0507.2003.00830.x","article-title":"Prevalence of Aspergillus fumigatus and other fungal species in the sputum of adult patients with cystic fibrosis","volume":"46","author":"Bakare","year":"2003","journal-title":"Mycoses"},{"issue":"2","key":"10.1378\/chest.09-2996_bib9","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jcf.2007.06.006","article-title":"Prevalence and antimicrobial susceptibility of microorganisms isolated from sputa of patients with cystic fibrosis","volume":"7","author":"Valenza","year":"2008","journal-title":"J Cyst Fibros"},{"key":"10.1378\/chest.09-2996_bib10","first-page":"128","article-title":"Bronchopulmonary mycoses in cystic fibrosis. Results of a five-year longitudinal study","volume":"10","author":"Cimon","year":"2000","journal-title":"J Mycol Med"},{"issue":"suppl 46","key":"10.1378\/chest.09-2996_bib11","first-page":"13","article-title":"Candida albicans infection in adults with cystic fibrosis","volume":"99","author":"Webb","year":"2006","journal-title":"J R Soc Med"},{"issue":"6944","key":"10.1378\/chest.09-2996_bib12","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1136\/bmj.308.6944.1609","article-title":"Vulvovaginal candidiasis in young women with cystic fibrosis","volume":"308","author":"Sawyer","year":"1994","journal-title":"BMJ"},{"issue":"3","key":"10.1378\/chest.09-2996_bib13","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1378\/chest.123.3.800","article-title":"Aspergillus infection in lung transplant recipients with cystic fibrosis: risk factors and outcomes comparison to other types of transplant recipients","volume":"123","author":"Helmi","year":"2003","journal-title":"Chest"},{"issue":"3","key":"10.1378\/chest.09-2996_bib14","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1183\/09031936.04.00052504","article-title":"Follow-up of 452 totally implantable vascular devices in cystic fibrosis patients","volume":"23","author":"Munck","year":"2004","journal-title":"Eur Respir J"},{"issue":"suppl 3","key":"10.1378\/chest.09-2996_bib15","doi-asserted-by":"crossref","first-page":"S225","DOI":"10.1086\/376525","article-title":"Allergic bronchopulmonary aspergillosis in cystic fibrosis\u2014state of the art: Cystic Fibrosis Foundation Consensus Conference","volume":"37","author":"Stevens","year":"2003","journal-title":"Clin Infect Dis"},{"issue":"10","key":"10.1378\/chest.09-2996_bib16","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1056\/NEJM199409083311003","article-title":"Effect of aerosolized recombinant human DNase on exacerbations of respiratory symptoms and on pulmonary function in patients with cystic fibrosis","volume":"331","author":"Fuchs","year":"1994","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1378\/chest.09-2996_bib17","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S1569-1993(02)00141-8","article-title":"Evaluation of a new definition for chronic Pseudomonas aeruginosa infection in cystic fibrosis patients","volume":"2","author":"Lee","year":"2003","journal-title":"J Cyst Fibros"},{"issue":"12","key":"10.1378\/chest.09-2996_bib18","doi-asserted-by":"crossref","first-page":"3804","DOI":"10.1128\/JCM.37.12.3804-3808.1999","article-title":"Identification of Candida dubliniensis based on temperature and utilization of xylose and alpha-methyl-D-glucoside as determined with the API 20C AUX and vitek YBC systems","volume":"37","author":"Gales","year":"1999","journal-title":"J Clin Microbiol"},{"issue":"3","key":"10.1378\/chest.09-2996_bib19","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1378\/chest.121.3.782","article-title":"Serologic IgE immune responses against Aspergillus fumigatus and Candida albicans in patients with cystic fibrosis","volume":"121","author":"M\u00e1iz","year":"2002","journal-title":"Chest"},{"issue":"3","key":"10.1378\/chest.09-2996_bib20","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1183\/09031936.02.00248102","article-title":"A randomised clinical trial of nebulised tobramycin or colistin in cystic fibrosis","volume":"20","author":"Hodson","year":"2002","journal-title":"Eur Respir J"},{"issue":"1","key":"10.1378\/chest.09-2996_bib21","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1056\/NEJM199901073400104","article-title":"Intermittent administration of inhaled tobramycin in patients with cystic fibrosis","volume":"340","author":"Ramsey","year":"1999","journal-title":"N Engl J Med"},{"issue":"suppl 1","key":"10.1378\/chest.09-2996_bib22","first-page":"43","article-title":"Mycological surveillance of children with cystic fibrosis [in German]","volume":"34","author":"Blaschke-Hellmessen","year":"1991","journal-title":"Mycoses"},{"issue":"4","key":"10.1378\/chest.09-2996_bib23","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1007\/BF01644143","article-title":"Serologic response to Candida albicans and Aspergillus fumigatus in cystic fibrosis","volume":"15","author":"Przyklenk","year":"1987","journal-title":"Infection"},{"issue":"3","key":"10.1378\/chest.09-2996_bib24","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1157\/13116602","article-title":"Aspergillus fumigatus and Candida albicans in cystic fibrosis: clinical significance and specific immune response involving serum immunoglobulins G, A, and M [in Spanish]","volume":"44","author":"M\u00e1iz","year":"2008","journal-title":"Arch Bronconeumol"},{"issue":"10","key":"10.1378\/chest.09-2996_bib25","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1093\/oxfordjournals.aje.a008664","article-title":"Determinants of mortality from cystic fibrosis in Canada, 1970\u20131989","volume":"143","author":"Corey","year":"1996","journal-title":"Am J Epidemiol"},{"issue":"4","key":"10.1378\/chest.09-2996_bib26","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1093\/aje\/153.4.345","article-title":"Predictive 5-year survivorship model of cystic fibrosis","volume":"153","author":"Liou","year":"2001","journal-title":"Am J Epidemiol"},{"issue":"5576","key":"10.1378\/chest.09-2996_bib27","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1126\/science.1070784","article-title":"Pseudomonas-Candida interactions: an ecological role for virulence factors","volume":"296","author":"Hogan","year":"2002","journal-title":"Science"},{"issue":"2","key":"10.1378\/chest.09-2996_bib28","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.mib.2009.01.005","article-title":"Quorum sensing and environmental adaptation in Pseudomonas aeruginosa: a tale of regulatory networks and multifunctional signal molecules","volume":"12","author":"Williams","year":"2009","journal-title":"Curr Opin Microbiol"},{"issue":"11","key":"10.1378\/chest.09-2996_bib29","doi-asserted-by":"crossref","first-page":"5459","DOI":"10.1128\/AEM.68.11.5459-5463.2002","article-title":"Inhibition of Candida albicans biofilm formation by farnesol, a quorum-sensing molecule","volume":"68","author":"Ramage","year":"2002","journal-title":"Appl Environ Microbiol"},{"issue":"Pt 5","key":"10.1378\/chest.09-2996_bib30","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1099\/jmm.0.47705-0","article-title":"Signal-mediated interactions between Pseudomonas aeruginosa and Candida albicans","volume":"57","author":"McAlester","year":"2008","journal-title":"J Med Microbiol"},{"issue":"3","key":"10.1378\/chest.09-2996_bib31","first-page":"139","article-title":"Medical importance of biofilms in Candida infections","volume":"19","author":"Douglas","year":"2002","journal-title":"Rev Iberoam Micol"},{"issue":"1","key":"10.1378\/chest.09-2996_bib32","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s00134-006-0422-0","article-title":"Impact of antifungal treatment on Candida-Pseudomonas interaction: a preliminary retrospective case-control study","volume":"33","author":"Nseir","year":"2007","journal-title":"Intensive Care Med"},{"issue":"3","key":"10.1378\/chest.09-2996_bib33","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1002\/eji.200838932","article-title":"Th2 allergic immune response to inhaled fungal antigens is modulated by TLR-4-independent bacterial products","volume":"39","author":"Allard","year":"2009","journal-title":"Eur J Immunol"},{"issue":"6","key":"10.1378\/chest.09-2996_bib34","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.jcf.2008.05.004","article-title":"Development of a novel PCR assay for the identification of the black yeast, Exophiala (Wangiella) dermatitidis from adult patients with cystic fibrosis (CF)","volume":"7","author":"Nagano","year":"2008","journal-title":"J Cyst Fibros"},{"issue":"6","key":"10.1378\/chest.09-2996_bib35","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.jcf.2008.06.007","article-title":"Development of selective media for the isolation of yeasts and filamentous fungi from the sputum of adult patients with cystic fibrosis (CF)","volume":"7","author":"Nagano","year":"2008","journal-title":"J Cyst Fibros"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369210605971?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369210605971?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T06:22:28Z","timestamp":1757917348000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369210605971"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["S0012369210605971"],"URL":"https:\/\/doi.org\/10.1378\/chest.09-2996","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[2010,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sputum Candida albicans Presages FEV1 Decline and Hospital-Treated Exacerbations in Cystic Fibrosis","name":"articletitle","label":"Article Title"},{"value":"Chest","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1378\/chest.09-2996","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 The American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}