{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:46:06Z","timestamp":1791326766055,"version":"4.3.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal.chestnet.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chest"],"published-print":{"date-parts":[[2011,5]]},"DOI":"10.1378\/chest.10-1304","type":"journal-article","created":{"date-parts":[[2010,9,30]],"date-time":"2010-09-30T21:10:22Z","timestamp":1285881022000},"page":"1060-1071","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":117,"title":["Neuroendocrine Cell Distribution and Frequency Distinguish Neuroendocrine Cell Hyperplasia of Infancy From Other Pulmonary Disorders"],"prefix":"10.1016","volume":"139","author":[{"given":"Lisa R.","family":"Young","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan S.","family":"Brody","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas H.","family":"Inge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D.","family":"Acton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald E.","family":"Bokulic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Langston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail H.","family":"Deutsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"suppl 23","key":"10.1378\/chest.10-1304_bib1","first-page":"72","article-title":"Persistent tachypnea of infancy (PTI)\u2014a new entity","author":"Deterding","year":"2001","journal-title":"Pediatr Pulmonol"},{"issue":"2","key":"10.1378\/chest.10-1304_bib2","first-page":"157","article-title":"Persistent tachypnea of infancy is associated with neuroendocrine cell hyperplasia","volume":"40","author":"Deterding","year":"2005","journal-title":"Pediatr Pulmonol"},{"issue":"12","key":"10.1378\/chest.10-1304_bib3","first-page":"1328","article-title":"Neuroendocrine cell hyperplasia of infancy (NEHI)","volume":"36","author":"Brody","year":"2006","journal-title":"Pediatr Radiol"},{"issue":"1","key":"10.1378\/chest.10-1304_bib4","first-page":"238","article-title":"Neuroendocrine cell hyperplasia of infancy: diagnosis with high-resolution CT","volume":"194","author":"Brody","year":"2010","journal-title":"AJR Am J Roentgenol"},{"issue":"6","key":"10.1378\/chest.10-1304_bib5","first-page":"421","article-title":"Diffuse lung disease in infancy: a proposed classification applied to 259 diagnostic biopsies","volume":"12","author":"Langston","year":"2009","journal-title":"Pediatr Dev Pathol"},{"issue":"1","key":"10.1378\/chest.10-1304_bib6","first-page":"245","article-title":"Bombesin and the C-terminal tetradecapeptide of gastrin-releasing peptide are growth factors for normal human bronchial epithelial cells","volume":"153","author":"Willey","year":"1984","journal-title":"Exp Cell Res"},{"issue":"3","key":"10.1378\/chest.10-1304_bib7","first-page":"199","article-title":"Bombesin increases fetal lung growth and maturation in utero and in organ culture","volume":"3","author":"Sunday","year":"1990","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"10","key":"10.1378\/chest.10-1304_bib8","first-page":"4357","article-title":"Bombesin and [Leu8]phyllolitorin promote fetal mouse lung branching morphogenesis via a receptor-mediated mechanism","volume":"92","author":"King","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"10.1378\/chest.10-1304_bib9","first-page":"425","article-title":"Intrapulmonary neuro-epithelial bodies in newborn rabbits. Influence of hypoxia, hyperoxia, hypercapnia, nicotine, reserpine, L-DOPA and 5-HTP","volume":"182","author":"Lauweryns","year":"1977","journal-title":"Cell Tissue Res"},{"key":"10.1378\/chest.10-1304_bib10","first-page":"95","article-title":"Tissue-specific expression of the mammalian bombesin gene","volume":"547","author":"Sunday","year":"1988","journal-title":"Ann N Y Acad Sci"},{"issue":"1","key":"10.1378\/chest.10-1304_bib11","first-page":"31","article-title":"Pulmonary endocrine cells in infancy and childhood","volume":"11","author":"Nakatani","year":"1991","journal-title":"Pediatr Pathol"},{"issue":"3","key":"10.1378\/chest.10-1304_bib12","first-page":"431","article-title":"Hyperplasia of bombesin-immunoreactive pulmonary neuroendocrine cells and neuroepithelial bodies in sudden infant death syndrome","volume":"11","author":"Perrin","year":"1991","journal-title":"Pediatr Pathol"},{"issue":"6","key":"10.1378\/chest.10-1304_bib13","first-page":"446","article-title":"Pulmonary neuroendocrine cells in hyaline membrane disease and bronchopulmonary dysplasia","volume":"16","author":"Johnson","year":"1982","journal-title":"Pediatr Res"},{"issue":"1","key":"10.1378\/chest.10-1304_bib14","first-page":"5","article-title":"Gastrin-releasing peptide (mammalian bombesin) gene expression in health and disease","volume":"59","author":"Sunday","year":"1988","journal-title":"Lab Invest"},{"issue":"1","key":"10.1378\/chest.10-1304_bib15","first-page":"115","article-title":"Pulmonary neuroendocrine cells in pediatric lung disease: alterations in airway structure in infants with bronchopulmonary dysplasia","volume":"236","author":"Johnson","year":"1993","journal-title":"Anat Rec"},{"issue":"2","key":"10.1378\/chest.10-1304_bib16","first-page":"106","article-title":"Pulmonary neuroendocrine cells and neuroepithelial bodies in sudden infant death syndrome: potential markers of airway chemoreceptor dysfunction","volume":"10","author":"Cutz","year":"2007","journal-title":"Pediatr Dev Pathol"},{"issue":"4 pt 1","key":"10.1378\/chest.10-1304_bib17","first-page":"1347","article-title":"Increased respiratory system resistance and bronchial smooth muscle hypertrophy in children with acute postoperative pulmonary hypertension","volume":"152","author":"Schindler","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"10.1378\/chest.10-1304_bib18","first-page":"123","article-title":"Changes in bombesin, calcitonin, and serotonin immunoreactive pulmonary neuroendocrine cells in cystic fibrosis and after prolonged mechanical ventilation","volume":"137","author":"Johnson","year":"1988","journal-title":"Am Rev Respir Dis"},{"issue":"5","key":"10.1378\/chest.10-1304_bib19","first-page":"326","article-title":"Urinary bombesin-like peptide levels in infants and children with bronchopulmonary dysplasia and cystic fibrosis","volume":"26","author":"Scher","year":"1998","journal-title":"Pediatr Pulmonol"},{"issue":"3 pt 1","key":"10.1378\/chest.10-1304_bib20","first-page":"L486","article-title":"Cell proliferation contributes to PNEC hyperplasia after acute airway injury","volume":"272","author":"Stevens","year":"1997","journal-title":"Am J Physiol"},{"issue":"1","key":"10.1378\/chest.10-1304_bib21","first-page":"269","article-title":"Neuroepithelial bodies of pulmonary airways serve as a reservoir of progenitor cells capable of epithelial regeneration","volume":"156","author":"Reynolds","year":"2000","journal-title":"Am J Pathol"},{"issue":"3","key":"10.1378\/chest.10-1304_bib22","first-page":"215","article-title":"Adult-type pulmonary function tests in infants without respiratory disease","volume":"30","author":"Castile","year":"2000","journal-title":"Pediatr Pulmonol"},{"issue":"2 pt 1","key":"10.1378\/chest.10-1304_bib23","first-page":"353","article-title":"Forced expiratory flows and volumes in infants. Normative data and lung growth","volume":"161","author":"Jones","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"issue":"11","key":"10.1378\/chest.10-1304_bib24","first-page":"1463","article-title":"ATS\/ERS statement: raised volume forced expirations in infants: guidelines for current practice","volume":"172","author":"American Thoracic Society","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.10-1304_bib25","first-page":"A3671","article-title":"Infant pulmonary function testing in children with neuroendocrine cell hyperplasia with and without lung biopsy","volume":"179","author":"Kerby","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"issue":"11","key":"10.1378\/chest.10-1304_bib26","first-page":"1060","article-title":"Classification of diffuse lung disease in infants: the reality of groups","volume":"176","author":"Nicholson","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"issue":"6","key":"10.1378\/chest.10-1304_bib27","first-page":"587","article-title":"Quantitative immunocytochemistry shows calcitonin gene-related peptide-like immunoreactivity in lung neuroendocrine cells is increased by chronic hypoxia in the rat","volume":"3","author":"McBride","year":"1990","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"4","key":"10.1378\/chest.10-1304_bib28","first-page":"539","article-title":"Hyperoxia-induced airway remodeling and pulmonary neuroendocrine cell hyperplasia in the weanling rat","volume":"42","author":"Shenberger","year":"1997","journal-title":"Pediatr Res"},{"issue":"11","key":"10.1378\/chest.10-1304_bib29","first-page":"1120","article-title":"Diffuse lung disease in young children: application of a novel classification scheme","volume":"176","author":"Deutsch","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"issue":"5","key":"10.1378\/chest.10-1304_bib30","first-page":"409","article-title":"Expression of gastrin-releasing peptide receptor gene in developing lung","volume":"14","author":"Wang","year":"1996","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"6","key":"10.1378\/chest.10-1304_bib31","first-page":"875","article-title":"Modulation of oncogene and tumor suppressor gene expression in a hamster model of chronic lung injury with varying degrees of pulmonary neuroendocrine cell hyperplasia","volume":"70","author":"Sunday","year":"1994","journal-title":"Lab Invest"},{"issue":"8","key":"10.1378\/chest.10-1304_bib32","first-page":"749","article-title":"Familial neuroendocrine cell hyperplasia of infancy","volume":"45","author":"Popler","year":"2010","journal-title":"Pediatr Pulmonol"},{"issue":"3","key":"10.1378\/chest.10-1304_bib33","first-page":"248","article-title":"Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: an under-recognised spectrum of disease","volume":"62","author":"Davies","year":"2007","journal-title":"Thorax"},{"issue":"6","key":"10.1378\/chest.10-1304_bib34","first-page":"419","article-title":"Pulmonary neuroendocrine cell system in pediatric lung disease-recent advances","volume":"10","author":"Cutz","year":"2007","journal-title":"Pediatr Dev Pathol"},{"issue":"3","key":"10.1378\/chest.10-1304_bib35","first-page":"789","article-title":"Evidence that neuroepithelial endocrine cells control the spontaneous tone in guinea pig tracheal preparations","volume":"86","author":"Skogvall","year":"1999","journal-title":"J Appl Physiol"},{"issue":"3","key":"10.1378\/chest.10-1304_bib36","first-page":"261","article-title":"Migration of 3T3 and lung fibroblasts in response to calcitonin gene-related peptide and bombesin","volume":"25","author":"Yule","year":"1999","journal-title":"Exp Lung Res"},{"issue":"5","key":"10.1378\/chest.10-1304_bib37","first-page":"601","article-title":"Bombesin-like peptides and mast cell responses: relevance to bronchopulmonary dysplasia?","volume":"168","author":"Subramaniam","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"issue":"3 pt 2","key":"10.1378\/chest.10-1304_bib38","first-page":"H681","article-title":"CGRP and somatostatin modulate chronic hypoxic pulmonary hypertension","volume":"263","author":"Tjen-A-Looi","year":"1992","journal-title":"Am J Physiol"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369211602304?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369211602304?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T06:24:57Z","timestamp":1757917497000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369211602304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,5]]}},"alternative-id":["S0012369211602304"],"URL":"https:\/\/doi.org\/10.1378\/chest.10-1304","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.716598018.792003083","asserted-by":"object"}]},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[2011,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuroendocrine Cell Distribution and Frequency Distinguish Neuroendocrine Cell Hyperplasia of Infancy From Other Pulmonary Disorders","name":"articletitle","label":"Article Title"},{"value":"Chest","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1378\/chest.10-1304","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 The American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}