{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:07:49Z","timestamp":1790806069100,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chest"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1378\/chest.10-3297","type":"journal-article","created":{"date-parts":[[2011,7,22]],"date-time":"2011-07-22T01:10:23Z","timestamp":1311297023000},"page":"121-130","source":"Crossref","is-referenced-by-count":51,"title":["IL-27 Is Elevated in Patients With COPD and Patients With Pulmonary TB and Induces Human Bronchial Epithelial Cells to Produce CXCL10"],"prefix":"10.1016","volume":"141","author":[{"given":"Ju","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dairong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shifeng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibing","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guosheng","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1378\/chest.10-3297_bib1","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1183\/09031936.96.09091913","article-title":"Bacterial-induced release of inflammatory mediators by bronchial epithelial cells","volume":"9","author":"Khair","year":"1996","journal-title":"Eur Respir J"},{"issue":"4","key":"10.1378\/chest.10-3297_bib2","first-page":"585","article-title":"Bronchial epithelium: morphology, function and pathophysiology in asthma","volume":"9","author":"Velden","year":"1998","journal-title":"Eur Cytokine Netw"},{"issue":"9","key":"10.1378\/chest.10-3297_bib3","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1183\/09031936.97.10092139","article-title":"Airway epithelium as an effector of inflammation: molecular regulation of secondary mediators","volume":"10","author":"Martin","year":"1997","journal-title":"Eur Respir J"},{"issue":"6","key":"10.1378\/chest.10-3297_bib4","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/j.jaci.2007.08.046","article-title":"Epithelium: at the interface of innate and adaptive immune responses","volume":"120","author":"Schleimer","year":"2007","journal-title":"J Allergy Clin Immunol"},{"issue":"6","key":"10.1378\/chest.10-3297_bib5","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.coi.2007.08.004","article-title":"Beyond inflammation: airway epithelial cells are at the interface of innate and adaptive immunity","volume":"19","author":"Kato","year":"2007","journal-title":"Curr Opin Immunol"},{"issue":"6","key":"10.1378\/chest.10-3297_bib6","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S1074-7613(02)00324-2","article-title":"IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells","volume":"16","author":"Pflanz","year":"2002","journal-title":"Immunity"},{"issue":"2","key":"10.1378\/chest.10-3297_bib7","doi-asserted-by":"crossref","first-page":"715","DOI":"10.4049\/jimmunol.173.2.715","article-title":"Understanding the pro- and anti-inflammatory properties of IL-27","volume":"173","author":"Villarino","year":"2004","journal-title":"J Immunol"},{"key":"10.1378\/chest.10-3297_bib8","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.0105-2896.2004.00213.x","article-title":"The role of IL-27 in the development of T-cell responses during parasitic infections","volume":"202","author":"Hunter","year":"2004","journal-title":"Immunol Rev"},{"issue":"1","key":"10.1378\/chest.10-3297_bib9","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jaci.2009.04.026","article-title":"IL-27 is expressed in chronic human eczematous skin lesions and stimulates human keratinocytes","volume":"124","author":"Wittmann","year":"2009","journal-title":"J Allergy Clin Immunol"},{"issue":"13","key":"10.1378\/chest.10-3297_bib10","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1084\/jem.20100064","article-title":"IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells","volume":"207","author":"Batten","year":"2010","journal-title":"J Exp Med"},{"issue":"4","key":"10.1378\/chest.10-3297_bib11","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.4049\/jimmunol.172.4.2225","article-title":"WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27","volume":"172","author":"Pflanz","year":"2004","journal-title":"J Immunol"},{"issue":"2","key":"10.1378\/chest.10-3297_bib12","doi-asserted-by":"crossref","first-page":"693","DOI":"10.4049\/jimmunol.180.2.693","article-title":"Cutting edge: T-bet and IL-27R are critical for in vivo IFN-gamma production by CD8 T cells during infection","volume":"180","author":"Mayer","year":"2008","journal-title":"J Immunol"},{"issue":"6","key":"10.1378\/chest.10-3297_bib13","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1158\/0008-5472.CAN-08-2793","article-title":"Interleukin-27 activates natural killer cells and suppresses NK-resistant head and neck squamous cell carcinoma through inducing antibody-dependent cellular cytotoxicity","volume":"69","author":"Matsui","year":"2009","journal-title":"Cancer Res"},{"issue":"12","key":"10.1378\/chest.10-3297_bib14","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1038\/ni1537","article-title":"Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10","volume":"8","author":"Stumhofer","year":"2007","journal-title":"Nat Immunol"},{"issue":"12","key":"10.1378\/chest.10-3297_bib15","doi-asserted-by":"crossref","first-page":"7490","DOI":"10.4049\/jimmunol.173.12.7490","article-title":"IL-27 signaling compromises control of bacterial growth in mycobacteria-infected mice","volume":"173","author":"Pearl","year":"2004","journal-title":"J Immunol"},{"issue":"9691","key":"10.1378\/chest.10-3297_bib16","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/S0140-6736(09)61342-8","article-title":"New drugs for exacerbations of chronic obstructive pulmonary disease","volume":"374","author":"Hansel","year":"2009","journal-title":"Lancet"},{"issue":"1","key":"10.1378\/chest.10-3297_bib17","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.tube.2010.08.007","article-title":"Optimization of inhaled therapies for tuberculosis: the role of macrophages and dendritic cells","volume":"91","author":"Gonz\u00e1lez-Juarrero","year":"2011","journal-title":"Tuberculosis (Edinb)"},{"issue":"2 pt 1","key":"10.1378\/chest.10-3297_bib18","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/S0091-6749(99)70497-5","article-title":"IL-4 and IL-5 mRNA expression in induced sputum of asthmatic subjects: comparison with bronchial wash","volume":"103","author":"Olivenstein","year":"1999","journal-title":"J Allergy Clin Immunol"},{"issue":"3","key":"10.1378\/chest.10-3297_bib19","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1002\/jcp.22094","article-title":"Activation of human bronchial epithelial cells by inflammatory cytokines IL-27 and TNF-alpha: implications for immunopathophysiology of airway inflammation","volume":"223","author":"Cao","year":"2010","journal-title":"J Cell Physiol"},{"issue":"8","key":"10.1378\/chest.10-3297_bib20","doi-asserted-by":"crossref","first-page":"5625","DOI":"10.4049\/jimmunol.180.8.5625","article-title":"Molecular mechanisms of cytokine and chemokine release from eosinophils activated by IL-17A, IL-17F, and IL-23: implication for Th17 lymphocytes-mediated allergic inflammation","volume":"180","author":"Cheung","year":"2008","journal-title":"J Immunol"},{"issue":"4","key":"10.1378\/chest.10-3297_bib21","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1183\/09031936.00088309","article-title":"Interleukin-17A activation on bronchial epithelium and basophils: a novel inflammatory mechanism","volume":"35","author":"Wong","year":"2010","journal-title":"Eur Respir J"},{"issue":"32","key":"10.1378\/chest.10-3297_bib22","doi-asserted-by":"crossref","first-page":"24404","DOI":"10.1074\/jbc.M110.112599","article-title":"Interleukin-27 induces a STAT1\/3- and NF-kappaB-dependent proinflammatory cytokine profile in human monocytes","volume":"285","author":"Guzzo","year":"2010","journal-title":"J Biol Chem"},{"issue":"4","key":"10.1378\/chest.10-3297_bib23","doi-asserted-by":"crossref","first-page":"R129","DOI":"10.1186\/ar3067","article-title":"Effects of inflammatory cytokine IL-27 on the activation of fibroblast-like synoviocytes in rheumatoid arthritis","volume":"12","author":"Wong","year":"2010","journal-title":"Arthritis Res Ther"},{"issue":"4","key":"10.1378\/chest.10-3297_bib24","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1067\/mai.2001.113524","article-title":"Expression of IFN-gamma-inducible protein; monocyte chemotactic proteins 1, 3, and 4; and eotaxin in TH1- and TH2-mediated lung diseases","volume":"107","author":"Miotto","year":"2001","journal-title":"J Allergy Clin Immunol"},{"issue":"10","key":"10.1378\/chest.10-3297_bib25","doi-asserted-by":"crossref","first-page":"5278","DOI":"10.4049\/jimmunol.168.10.5278","article-title":"IFN-gamma-inducible protein 10 (CXCL10) contributes to airway hyperreactivity and airway inflammation in a mouse model of asthma","volume":"168","author":"Medoff","year":"2002","journal-title":"J Immunol"},{"issue":"2","key":"10.1378\/chest.10-3297_bib26","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.humimm.2008.11.003","article-title":"Augmented chemokine levels and chemokine receptor expression on immune cells during pulmonary tuberculosis","volume":"70","author":"Pokkali","year":"2009","journal-title":"Hum Immunol"},{"issue":"10","key":"10.1378\/chest.10-3297_bib27","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1164\/rccm.2107139","article-title":"Increased expression of the chemokine receptor CXCR3 and its ligand CXCL10 in peripheral airways of smokers with chronic obstructive pulmonary disease","volume":"165","author":"Saetta","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"issue":"5","key":"10.1378\/chest.10-3297_bib28","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1378\/chest.124.5.1909","article-title":"Marked up-regulation of T lymphocytes and expression of interleukin-9 in bronchial biopsies from patients with chronic bronchitis with obstruction","volume":"124","author":"Panzner","year":"2003","journal-title":"Chest"},{"issue":"12","key":"10.1378\/chest.10-3297_bib29","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1373\/clinchem.2005.054460","article-title":"Early enhanced expression of interferon-inducible protein-10 (CXCL-10) and other chemokines predicts adverse outcome in severe acute respiratory syndrome","volume":"51","author":"Tang","year":"2005","journal-title":"Clin Chem"},{"issue":"6","key":"10.1378\/chest.10-3297_bib30","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1016\/j.jaci.2007.02.036","article-title":"The IL-17F signaling pathway is involved in the induction of IFN-gamma-inducible protein 10 in bronchial epithelial cells","volume":"119","author":"Kawaguchi","year":"2007","journal-title":"J Allergy Clin Immunol"},{"issue":"6","key":"10.1378\/chest.10-3297_bib31","doi-asserted-by":"crossref","first-page":"3549","DOI":"10.4049\/jimmunol.162.6.3549","article-title":"The T cell-specific CXC chemokines IP-10, Mig, and I-TAC are expressed by activated human bronchial epithelial cells","volume":"162","author":"Sauty","year":"1999","journal-title":"J Immunol"},{"issue":"4","key":"10.1378\/chest.10-3297_bib32","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.4049\/jimmunol.180.4.2538","article-title":"Isoform-specific functions of phosphoinositide 3-kinases: p110 delta but not p110 gamma promotes optimal allergic responses in vivo","volume":"180","author":"Ali","year":"2008","journal-title":"J Immunol"},{"issue":"5224","key":"10.1378\/chest.10-3297_bib33","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1126\/science.7624799","article-title":"Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase","volume":"269","author":"Stoyanov","year":"1995","journal-title":"Science"},{"issue":"9","key":"10.1378\/chest.10-3297_bib34","doi-asserted-by":"crossref","first-page":"4330","DOI":"10.1073\/pnas.94.9.4330","article-title":"P110d, a novel phosphoinositide 3-kinase in leukocytes","volume":"94","author":"Vanhaesebroeck","year":"1997","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369212600221?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369212600221?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T23:03:59Z","timestamp":1712617439000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369212600221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["S0012369212600221"],"URL":"https:\/\/doi.org\/10.1378\/chest.10-3297","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[2012,1]]}}}