{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:46:08Z","timestamp":1790034368987,"version":"4.0.1"},"reference-count":33,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[1992,3,1]],"date-time":"1992-03-01T00:00:00Z","timestamp":699408000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chest"],"published-print":{"date-parts":[[1992,3]]},"DOI":"10.1378\/chest.101.3.753","type":"journal-article","created":{"date-parts":[[2007,11,7]],"date-time":"2007-11-07T18:28:23Z","timestamp":1194460103000},"page":"753-757","source":"Crossref","is-referenced-by-count":68,"title":["Theophylline in Obstructive Sleep Apnea"],"prefix":"10.1016","volume":"101","author":[{"given":"Eithne","family":"Mulloy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter T.","family":"McNicholas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1378\/chest.101.3.753_bib1","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1164\/ajrccm\/136.1.80","article-title":"The effects of aminophylline on sleep and sleep-disordered breathing in patients with obstructive sleep apnea","volume":"136","author":"Espinoza","year":"1987","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.101.3.753_bib2","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1136\/thx.37.1.49","article-title":"Protriptyline in the treatment of sleep apnoea","volume":"37","author":"Conway","year":"1982","journal-title":"Thorax"},{"key":"10.1378\/chest.101.3.753_bib3","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1164\/arrd.1983.127.1.8","article-title":"The effects of protriptyline in sleep-disordered breathing","volume":"127","author":"Smith","year":"1983","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.101.3.753_bib4","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1056\/NEJM198210213071701","article-title":"Protriptyline in obstructive sleep apnea: a double-blind trial","volume":"307","author":"Brownell","year":"1982","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.101.3.753_bib5","first-page":"5","article-title":"A double blind trial of protriptyline in the treatment of sleep apnea syndrome","volume":"36","author":"Stepanski","year":"1988","journal-title":"Henry Ford Hosp Med J"},{"key":"10.1378\/chest.101.3.753_bib6","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1378\/chest.96.2.262","article-title":"Indices of severity of obstructive sleep apnea do not change during medroxyprogesterone acetate therapy","volume":"96","author":"Cook","year":"1989","journal-title":"Chest"},{"key":"10.1378\/chest.101.3.753_bib7","first-page":"433","article-title":"Treatment of sleep apnea with an evening dose of sustained-release theophylline (Euphylong)","volume":"41","author":"Peter","year":"1987","journal-title":"Prax Klin Pneumol"},{"issue":"suppl","key":"10.1378\/chest.101.3.753_bib8","first-page":"252","article-title":"Long-term theophylline therapy of sleep apnea syndrome (abstract)","volume":"129","author":"Mayer","year":"1984","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.101.3.753_bib9","first-page":"632","article-title":"Naloxone, theophylline, bromocriptine and obstructive sleep apnea; negative results","volume":"19","author":"Guilleminault","year":"1983","journal-title":"Bull Eur Physiopathol Respir"},{"key":"10.1378\/chest.101.3.753_bib10","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0140-6736(00)72581-5","article-title":"Theophylline-ethylinediamine in Cheyne-Stokes respiration","volume":"2","author":"Marais","year":"1937","journal-title":"Lancet"},{"key":"10.1378\/chest.101.3.753_bib11","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1152\/jappl.1949.2.1.16","article-title":"Action of caffeine and aminophylline as respiratory stimulants in man","volume":"2","author":"Richmond","year":"1949","journal-title":"J Appl Physiol"},{"key":"10.1378\/chest.101.3.753_bib12","series-title":"The pharmaceutical basis of therapeutics","first-page":"592","article-title":"Central nervous system stimulants: the zanthines","author":"Rall","year":"1980"},{"key":"10.1378\/chest.101.3.753_bib13","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1136\/thx.44.2.121","article-title":"Increase in ventilation caused by aminophylline in the absence of changes in ventral medullary extracellular fluid pH and carbon dioxide tension","volume":"44","author":"Javaheri","year":"1989","journal-title":"Thorax"},{"key":"10.1378\/chest.101.3.753_bib14","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1042\/cs0380549","article-title":"The effect of aminophylline on the respiration and pulmonary circulation","volume":"38","author":"Jezek","year":"1970","journal-title":"Clin Sci"},{"key":"10.1378\/chest.101.3.753_bib15","first-page":"33","article-title":"Effect of aminophylline on ventilatory responses in normal man","volume":"117","author":"Lakshminarayan","year":"1978","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.101.3.753_bib16","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0002-9343(57)90192-4","article-title":"Effects of aminophylline and Diamox alone and together on respiration and acid-base balance and on respiratory response to carbon dioxide in pulmonary emphysema","volume":"23","author":"Galdston","year":"1957","journal-title":"Am J Med"},{"key":"10.1378\/chest.101.3.753_bib17","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1056\/NEJM196512302732702","article-title":"Effect of aminophylline on respiratory-centre sensitivity in Cheyne-Stokes respiration and in pulmonary emphysema","volume":"273","author":"Dowell","year":"1963","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.101.3.753_bib18","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1542\/peds.68.2.183","article-title":"Treatment of apnea and excessive periodic breathing in the full-term infant","volume":"68","author":"Kelly","year":"1981","journal-title":"Pediatrics"},{"key":"10.1378\/chest.101.3.753_bib19","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1056\/NEJM198107303050503","article-title":"Aminophylline improves diaphragmatic contractility","volume":"305","author":"Aubier","year":"1981","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.101.3.753_bib20","series-title":"Sleep and breathing","first-page":"299","article-title":"Pathophysiology of sleep apnea","author":"Sullivan","year":"1984"},{"key":"10.1378\/chest.101.3.753_bib21","first-page":"909","article-title":"Control of breathing during sleep","volume":"118","author":"Phillipson","year":"1978","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.101.3.753_bib22","first-page":"167","article-title":"Pathogenesis of apneas in hypersomnia-sleep apnea syndrome","volume":"126","author":"Onal","year":"1982","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.101.3.753_bib23","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1152\/jappl.1978.44.6.931","article-title":"Pathogenesis of upper airway occlusion during sleep","volume":"44","author":"Remmers","year":"1978","journal-title":"J Appl Physiol"},{"key":"10.1378\/chest.101.3.753_bib24","series-title":"A manual of standardized terminology, techniques and scoring system for sleep stages of human subjects","year":"1968"},{"key":"10.1378\/chest.101.3.753_bib25","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1152\/jappl.1967.22.3.407","article-title":"Measurement of the separate volume changes of ribcage and abdomen during breathing","volume":"22","author":"Konno","year":"1967","journal-title":"J Appl Physiol"},{"key":"10.1378\/chest.101.3.753_bib26","first-page":"209","article-title":"Postural changes in ribcage and abdominal volume-motion coefficients and their effect on the calibration of a respiratory inductance plethysmograph","volume":"127","author":"Zimmerman","year":"1983","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.101.3.753_bib27","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1152\/jappl.1984.56.6.1659","article-title":"Accuracy of tidal volume, lung volume and flow measurements by inductance vest in COPD patients","volume":"56","author":"Hudgel","year":"1984","journal-title":"J Appl Physiol"},{"key":"10.1378\/chest.101.3.753_bib28","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1056\/NEJM197903083001001","article-title":"Sleep apnea, hypopnea and oxygen desaturation in normal subjects","volume":"300","author":"Block","year":"1979","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.101.3.753_bib29","first-page":"41","article-title":"Differential elevation by protryptyline and depression by diazepam of upper airway respiratory motor activity","volume":"131","author":"Bonora","year":"1985","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.101.3.753_bib30","first-page":"180","article-title":"Upper airway occlusion induced by diaphragmatic pacing for primary alveolar hypoventilation: implications for the pathogenesis of obstructive sleep apnea","volume":"124","author":"Hyland","year":"1981","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.101.3.753_bib31","first-page":"899","article-title":"Effect of sleep fragmentation on ventilator and arousal responses of sleeping dogs to respiratory stimuli","volume":"122","author":"Bowes","year":"1980","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.101.3.753_bib32","first-page":"341","article-title":"The arousal threshold: sleep deprivation, sleep fragmentation and obstructive sleep apnea syndrome","volume":"17","author":"Guilleminault","year":"1981","journal-title":"Bull Eur Physiopathol Respir"},{"key":"10.1378\/chest.101.3.753_bib33","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1056\/NEJM197506052922305","article-title":"Dosage of theophylline in bronchial asthma","volume":"292","author":"Piafsky","year":"1975","journal-title":"N Engl J Med"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369216319511?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369216319511?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,2,18]],"date-time":"2024-02-18T22:29:40Z","timestamp":1708295380000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369216319511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,3]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1992,3]]}},"alternative-id":["S0012369216319511"],"URL":"https:\/\/doi.org\/10.1378\/chest.101.3.753","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[1992,3]]}}}