{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T20:41:17Z","timestamp":1780087277727,"version":"3.54.0"},"reference-count":22,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[1993,1,1]],"date-time":"1993-01-01T00:00:00Z","timestamp":725846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1993,1,1]],"date-time":"1993-01-01T00:00:00Z","timestamp":725846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal.chestnet.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chest"],"published-print":{"date-parts":[[1993,1]]},"DOI":"10.1378\/chest.103.1.183","type":"journal-article","created":{"date-parts":[[2007,11,7]],"date-time":"2007-11-07T13:28:23Z","timestamp":1194442103000},"page":"183-187","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Decrease of Skin and Bronchial Sensitization Following Short-intensive Scheduled Immunotherapy in Mite-Allergic Asthma"],"prefix":"10.1016","volume":"103","author":[{"given":"Pilar","family":"Garc\u00eda-Ortega","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adoraci\u00f3n","family":"Merelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaume","family":"Marrugat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crist\u00f3bal","family":"Richart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1378\/chest.103.1.183_bib1","series-title":"Allergy: principles and practice","first-page":"1327","article-title":"Immunotherapy for aeroallergen disease","author":"Van Metre","year":"1988"},{"key":"10.1378\/chest.103.1.183_bib2","series-title":"Harrisons principles of internal medicine","first-page":"1047","article-title":"Asthma","author":"Mc Fadden","year":"1991"},{"key":"10.1378\/chest.103.1.183_bib3","first-page":"259","article-title":"Current status of allergen immunotherapy","volume":"1","year":"1989","journal-title":"Lancet"},{"key":"10.1378\/chest.103.1.183_bib4","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1136\/bmj.293.6552.948","article-title":"Desensitizing vaccines","volume":"293","year":"1986","journal-title":"Br Med J"},{"key":"10.1378\/chest.103.1.183_bib5","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/0091-6749(86)90076-X","article-title":"Seasonal asthma in northern California: allergic causes and efficacy of immunotherapy","volume":"78","author":"Reid","year":"1986","journal-title":"J Allergy Clin Immunol"},{"key":"10.1378\/chest.103.1.183_bib6","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/0091-6749(91)90379-3","article-title":"Allergen standardization","volume":"87","author":"Platts-Mills","year":"1991","journal-title":"J Allergy Clin Immunol"},{"key":"10.1378\/chest.103.1.183_bib7","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/0091-6749(88)90144-3","article-title":"Immunotherapy for cat asthma","volume":"82","author":"Van Metre","year":"1988","journal-title":"J Allergy Clin Immunol"},{"key":"10.1378\/chest.103.1.183_bib8","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/0091-6749(86)90183-1","article-title":"Immunotherapy with partially purified and standardized animal dander extracts: I. Clinical results from a double-blind study on patients with animal dander asthma","volume":"77","author":"Sundin","year":"1986","journal-title":"J Allergy Clin Immunol"},{"key":"10.1378\/chest.103.1.183_bib9","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S0091-6749(05)80091-0","article-title":"Specific immunotherapy in asthma","volume":"86","author":"Bousquet","year":"1991","journal-title":"J Allergy Clin Immunol"},{"key":"10.1378\/chest.103.1.183_bib10","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/0091-6749(85)90680-3","article-title":"Immunotherapy with a standardized Dermatophagoides pterronyssinus extract: I. In-vivo and in-vitro parameters after a short course of treatment","volume":"76","author":"Bousquet","year":"1985","journal-title":"J Allergy Clin Immunol"},{"key":"10.1378\/chest.103.1.183_bib11","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/j.1398-9995.1989.tb04167.x","article-title":"The current status of allergen immunotherapy (hyposensitization)","volume":"44","year":"1989","journal-title":"Allergy"},{"key":"10.1378\/chest.103.1.183_bib12","first-page":"11","article-title":"Guidelines for bronchial inhalation challenges with pharmacological and antigenic agents","year":"1980","journal-title":"American Thoracic Society"},{"key":"10.1378\/chest.103.1.183_bib13","series-title":"Statistical method in biological assay","first-page":"69","article-title":"Parallel-line assays","author":"Finney","year":"1978"},{"issue":"suppl 10","key":"10.1378\/chest.103.1.183_bib14","first-page":"47","article-title":"Evaluation of changes in skin sensitivity by means of skin tests","volume":"44","author":"Dreborg","year":"1989","journal-title":"Allergy"},{"key":"10.1378\/chest.103.1.183_bib15","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/j.1398-9995.1989.tb04188.x","article-title":"Hyposensitization in asthmatics with mPEG modified and unmodified dust mite: I. Clinical effect evaluated by diary cards and a retrospective assessment","volume":"44","author":"Mosbech","year":"1989","journal-title":"Allergy"},{"key":"10.1378\/chest.103.1.183_bib16","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/j.1365-2222.1991.tb01670.x","article-title":"Change in the levels of house dust mite specific IgG4 during immunotherapy in asthmatic children","volume":"21","author":"Tsai","year":"1991","journal-title":"Clin Exp Allergy"},{"key":"10.1378\/chest.103.1.183_bib17","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/j.1398-9995.1989.tb04189.x","article-title":"Hyposensitization in asthmatics with mPEG modified and unmodified house dust mite extract: II. Effect evaluated by challenge with allergen and histamine","volume":"44","author":"Mosbech","year":"1990","journal-title":"Allergy"},{"key":"10.1378\/chest.103.1.183_bib18","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1398-9995.1990.tb00495.x","article-title":"St\u00e5lenheim G. Factors influencing the occurrence of late bronchial reactions after allergen challenge","volume":"45","author":"Machado","year":"1990","journal-title":"Allergy"},{"key":"10.1378\/chest.103.1.183_bib19","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/j.1365-2222.1989.tb02405.x","article-title":"Suppression of the late asthmatic reaction by hyposensitization in asthmatic children allergic to house dust mite (Dermatophagoides pteronyssinus)","volume":"19","author":"Van Bever","year":"1989","journal-title":"Clin Exp Allergy"},{"key":"10.1378\/chest.103.1.183_bib20","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1398-9995.1986.tb00290.x","article-title":"A double-blind, multicenter immunotherapy trial in children using a purified and standardized Cladosporium herbarum preparation","volume":"41","author":"Karlsson","year":"1986","journal-title":"Allergy"},{"key":"10.1378\/chest.103.1.183_bib21","first-page":"30","article-title":"Hyposensitization in asthmatics with mPEG-modified and unmodified house dust mite extract: III. Effect on mite-specific immunological parameters and correlation to changes in mite-sensitivity and symptoms","volume":"45","author":"Mosbech","year":"1990","journal-title":"Allergy"},{"key":"10.1378\/chest.103.1.183_bib22","doi-asserted-by":"crossref","first-page":"345","DOI":"10.3109\/02770908909073276","article-title":"IgG4 antibodies and their role in asthmatic patients","volume":"26","author":"Halpem","year":"1989","journal-title":"J Asthma"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369216383192?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369216383192?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T07:43:48Z","timestamp":1757922228000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369216383192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,1]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1993,1]]}},"alternative-id":["S0012369216383192"],"URL":"https:\/\/doi.org\/10.1378\/chest.103.1.183","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[1993,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Decrease of Skin and Bronchial Sensitization Following Short-intensive Scheduled Immunotherapy in Mite-Allergic Asthma","name":"articletitle","label":"Article Title"},{"value":"Chest","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1378\/chest.103.1.183","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1993 The American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}