{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:07:41Z","timestamp":1767704861370,"version":"3.44.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[1993,4,1]],"date-time":"1993-04-01T00:00:00Z","timestamp":733622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1993,4,1]],"date-time":"1993-04-01T00:00:00Z","timestamp":733622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal.chestnet.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chest"],"published-print":{"date-parts":[[1993,4]]},"DOI":"10.1378\/chest.103.4.1017","type":"journal-article","created":{"date-parts":[[2007,11,7]],"date-time":"2007-11-07T13:28:23Z","timestamp":1194442103000},"page":"1017-1022","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["Pilot Study of Cardiopulmonary Risk from Pentoxifylline in Adult Respiratory Distress Syndrome"],"prefix":"10.1016","volume":"103","author":[{"given":"Philippe","family":"Montravers","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Yves","family":"Fagon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claude","family":"Gilbert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7oise","family":"Blanchet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Novara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Chastre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1378\/chest.103.4.1017_bib1","first-page":"218","article-title":"Lung neutrophils in the adult respiratory distress syndrome: clinical and pathophysiologic significance","volume":"133","author":"Weiland","year":"1986","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.103.4.1017_bib2","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1378\/chest.89.4.590","article-title":"Mediation of ARDS by leukocytes-clinical evidence and implications for therapy","volume":"89","author":"Rinaldo","year":"1986","journal-title":"Chest"},{"key":"10.1378\/chest.103.4.1017_bib3","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1056\/NEJM198608283150904","article-title":"Adult respiratory distress syndrome in patients with severe neutropenia","volume":"315","author":"Ognibene","year":"1986","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.103.4.1017_bib4","first-page":"313","article-title":"Occurrence of the adult respiratory distress syndrome in neutropenic patients","volume":"133","author":"Maunder","year":"1986","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.103.4.1017_bib5","first-page":"97","article-title":"Acute inflammation in gram-negative infection: endotoxin, interleukin 1, tumor necrosis factor, and neutrophils","volume":"46","author":"Movat","year":"1987","journal-title":"Fed Proc"},{"key":"10.1378\/chest.103.4.1017_bib6","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1152\/jappl.1987.63.5.2093","article-title":"Monokine-induced acute lung injury in rabbits","volume":"63","author":"Goldblum","year":"1987","journal-title":"J Appl Physiol"},{"key":"10.1378\/chest.103.4.1017_bib7","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1164\/ajrccm\/137.6.1364","article-title":"Tumor necrosis factor causes increased pulmonary permeability and edema: comparison to septic acute lung injury","volume":"137","author":"Stephens","year":"1988","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.103.4.1017_bib8","first-page":"1113","article-title":"Actions of tumor necrosis factor on cultured vascular endothelial cells: morphologic modulation, growth inhibition, and cytotoxicity","volume":"76","author":"Sato","year":"1986","journal-title":"J Natl Cancer Inst"},{"key":"10.1378\/chest.103.4.1017_bib9","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1128\/iai.56.7.1722-1729.1988","article-title":"Inhibition of the inflammatory action of interleukin-1 and tumor necrosis factor (alpha) on neutrophil function by pentoxifylline","volume":"56","author":"Sullivan","year":"1988","journal-title":"Infect Immun"},{"key":"10.1378\/chest.103.4.1017_bib10","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1164\/ajrccm\/140.4.974","article-title":"The effects of aminophylline and pentoxifylline on multiple organ damage after Escherichia coli sepsis","volume":"140","author":"Harada","year":"1989","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.103.4.1017_bib11","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1164\/ajrccm\/139.6.1361","article-title":"Pentoxifylline prevents tumor necrosis factor-induced lung injury","volume":"139","author":"Lilly","year":"1989","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.103.4.1017_bib12","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1164\/ajrccm\/138.5.1106","article-title":"Pentoxifylline decreases endotoxin-induced pulmonary neutrophil sequestration and extravascular protein accumulation in the dog","volume":"138","author":"Welsh","year":"1988","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.103.4.1017_bib13","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1164\/ajrccm\/138.2.376","article-title":"Attenuation of acute lung injury in septic guinea pigs by pentoxifylline","volume":"138","author":"Ishizaka","year":"1988","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.103.4.1017_bib14","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1164\/ajrccm\/142.5.1083","article-title":"Effect of pentoxifylline on hemodynamics, alveolar fluid reabsorption, and pulmonary edema in a model of acute lung injury","volume":"142","author":"Seear","year":"1990","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.103.4.1017_bib15","series-title":"Methods in clinical pharmacology","article-title":"Central haemodynamics and coronary artery blood flow after administration of pentoxifylline to patients with coronary artery disease: a preoperative study: theophylline and other methylxanthines","author":"Ekestr\u00f6m","year":"1981"},{"key":"10.1378\/chest.103.4.1017_bib16","first-page":"385","article-title":"The effect of pentoxifylline on central and peripheral haemodynamics-an experimental clinical study","volume":"65","author":"Heidrich","year":"1976","journal-title":"Z Kardiol"},{"issue":"suppl 4","key":"10.1378\/chest.103.4.1017_bib17","first-page":"93","article-title":"Wirkung von iv.-Gabe von Pentoxifyllin bei Pat. mit koronarer Herzkrankheit unter Belastung auf Herzrhythmus, globale und regionale Funktion des linken Ventrikels [abstract 225)","volume":"63","author":"Richter","year":"1985","journal-title":"Klin Wochenschr"},{"key":"10.1378\/chest.103.4.1017_bib18","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1097\/00003246-198510000-00009","article-title":"APACHE II: a severity of disease classification system","volume":"13","author":"Knaus","year":"1985","journal-title":"Crit Care Med"},{"key":"10.1378\/chest.103.4.1017_bib19","first-page":"183","article-title":"High-performance liquid chromatographic determination of pentoxifylline and its hydroxy metabolite in human plasma","volume":"416","author":"Garnier-Moiroux","year":"1987","journal-title":"J Chromatogr"},{"issue":"suppl 1","key":"10.1378\/chest.103.4.1017_bib20","first-page":"5","article-title":"The biochemical mechanism of action of pentoxifylline","volume":"2","author":"Stefanovitch","year":"1978","journal-title":"Pharmatherapeutica"},{"key":"10.1378\/chest.103.4.1017_bib21","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/BF02886841","article-title":"Pulmonary vascular reactivity and hemorheology in patients with chronic cor pulmonale: responses to pentoxifylline at rest and during exercise","volume":"16","author":"Sturani","year":"1986","journal-title":"Ric Clin Lab"},{"key":"10.1378\/chest.103.4.1017_bib22","first-page":"1315","article-title":"The release of prostacyclin (PGI2) by pentoxifylline from human vascular tissues","volume":"32","author":"Matzky","year":"1982","journal-title":"Arzneim Forsch"},{"key":"10.1378\/chest.103.4.1017_bib23","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1056\/NEJM198708133170701","article-title":"The effects of vasodilation with prostacyclin on oxygen delivery and uptake in critically ill patients","volume":"317","author":"Bihari","year":"1987","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.103.4.1017_bib24","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1097\/00000542-198904000-00008","article-title":"Prostaglandin E1 and nitroglycerin reduce pulmonary capillary pressure but worsen ventilation-perfusion distributions in patients with adult respiratory distress syndrome","volume":"70","author":"Radermacher","year":"1989","journal-title":"Anesthesiology"},{"key":"10.1378\/chest.103.4.1017_bib25","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1164\/ajrccm\/137.5.1099","article-title":"Effects of pentoxifylline on pulmonary hemodynamics during acute hypoxia in anesthetized dogs","volume":"137","author":"Chick","year":"1988","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.103.4.1017_bib26","first-page":"919","article-title":"Ventilation-perfusion relationship","volume":"116","author":"West","year":"1977","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.103.4.1017_bib27","series-title":"Pentoxifylline and analogues: effects on leukocyte function","first-page":"175","article-title":"Preventive effects of pentoxifylline on methacholine induced bronchoconstriction in asthmatic subjects","author":"Drici","year":"1990"},{"key":"10.1378\/chest.103.4.1017_bib28","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/j.1552-4604.1985.tb02796.x","article-title":"Clinical pharmacology of pentoxifylline with special reference to its hemorheologic effect for the treatment of intermittent claudication","volume":"25","author":"Dettelbach","year":"1985","journal-title":"J Clin Pharmacol"},{"key":"10.1378\/chest.103.4.1017_bib29","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/clpt.1985.6","article-title":"Kinetics of intravenous and oral pentoxifylline in healthy subjects","volume":"37","author":"Beermann","year":"1985","journal-title":"Clin Pharmacol Ther"},{"key":"10.1378\/chest.103.4.1017_bib30","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/BF00637503","article-title":"The pharmacokinetics of oxpentifylline in man when administered by constant intravenous infusion","volume":"23","author":"Ings","year":"1982","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1378\/chest.103.4.1017_bib31","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/S0026-895X(25)09454-4","article-title":"Pentoxifylline inhibition of procoagulant activity generated by activated mononuclear phagocytes","volume":"38","author":"De Prost","year":"1990","journal-title":"Mol Pharmacol"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215417854?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215417854?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T07:14:09Z","timestamp":1757920449000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369215417854"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,4]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1993,4]]}},"alternative-id":["S0012369215417854"],"URL":"https:\/\/doi.org\/10.1378\/chest.103.4.1017","relation":{},"ISSN":["0012-3692"],"issn-type":[{"type":"print","value":"0012-3692"}],"subject":[],"published":{"date-parts":[[1993,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pilot Study of Cardiopulmonary Risk from Pentoxifylline in Adult Respiratory Distress Syndrome","name":"articletitle","label":"Article Title"},{"value":"Chest","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1378\/chest.103.4.1017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1993 The American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}