{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T04:26:58Z","timestamp":1781756818546,"version":"3.54.5"},"reference-count":17,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[1996,3,1]],"date-time":"1996-03-01T00:00:00Z","timestamp":825638400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chest"],"published-print":{"date-parts":[[1996,3]]},"DOI":"10.1378\/chest.109.3.702","type":"journal-article","created":{"date-parts":[[2008,1,22]],"date-time":"2008-01-22T22:31:17Z","timestamp":1201041077000},"page":"702-707","source":"Crossref","is-referenced-by-count":50,"title":["Cumulative Dose-Response Study of Non-CFC Propellant HFA 134a Salbutamol Sulfate Metered-Dose Inhaler in Patients With Asthma"],"prefix":"10.1016","volume":"109","author":[{"given":"Eric C.","family":"Kleerup","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald P.","family":"Tashkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann C.","family":"Cline","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce P.","family":"Ekholm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1378\/chest.109.3.702_bib1","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1183\/09031936.93.03050495","article-title":"Metered dose pressurized aerosols and the ozone layer","volume":"3","author":"Newman","year":"1990","journal-title":"Eur Respir J"},{"key":"10.1378\/chest.109.3.702_bib2","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1038\/249810a0","article-title":"Stratospheric sink for chlorofluoromethanes: chlorine atom-catalyzed destruction of ozone","volume":"249","author":"Molina","year":"1974","journal-title":"Nature"},{"key":"10.1378\/chest.109.3.702_bib3","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1126\/science.249.4964.31","article-title":"The CFC-ozone issue: progress on the development of alternatives to CFCs","volume":"249","author":"Manzer","year":"1990","journal-title":"Science"},{"key":"10.1378\/chest.109.3.702_bib4","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/344513a0","article-title":"Model calculations of the relative effects of CFCs and their replacements on global warming","volume":"344","author":"Fisher","year":"1990","journal-title":"Nature"},{"key":"10.1378\/chest.109.3.702_bib5","unstructured":"United Nations Environment Programme. Handbook for the Montreal protocol on substances that deplete the ozone layer. 3rd ed. Nairobi, Kenya: United Nations Environmental Programme, Ozone Secretariat, 1993; 8"},{"key":"10.1378\/chest.109.3.702_bib6","unstructured":"United Nations Environment Programme. Report of the technology and economic assessment panel: Montreal protocol on substances that deplete the ozone layer. Nairobi, Kenya: United Nations Environment Programme, Ozone Secretariat, 1995; 89-99"},{"key":"10.1378\/chest.109.3.702_bib7","unstructured":"International consensus report on diagnosis and treatment of asthma. Clin Exp Allergy 1992; 22:1-72"},{"key":"10.1378\/chest.109.3.702_bib8","doi-asserted-by":"crossref","unstructured":"Guidelines for the management of asthma. Statement by the British Thoracic Society, the British Paediatric Association, the Research Unit of the Royal College of Physicians of London, the King's Fund Centre, the National Asthma Campaign, the Royal College of General Practitioners, the General Practitioners in Asthma Group, the British Association of Accident and Emergency Medicine, and the British Paediatric Respiratory Group. Thorax 1993; 48:S1-24","DOI":"10.1136\/thx.48.2_Suppl.S1"},{"key":"10.1378\/chest.109.3.702_bib9","first-page":"755","article-title":"Normal values and the evaluation of forced end-expiratory flow","volume":"111","author":"Morris","year":"1975","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.109.3.702_bib10","unstructured":"Metropolitan Life Foundation. 1983 Metropolitan height and weight tables. Stat Bull Metrop life Found 1983; 64:2-9"},{"key":"10.1378\/chest.109.3.702_bib11","doi-asserted-by":"crossref","unstructured":"American Thoracic Society. Standardization of spirometry-1987 update. Am Rev Respir Dis 1987; 136:1285-98","DOI":"10.1164\/ajrccm\/136.5.1285"},{"key":"10.1378\/chest.109.3.702_bib12","first-page":"A58","article-title":"A placebo controlled comparison of the dose-response effects of salbutamol sulfate in chlorofluorocarbon (CFC) vs hydrofluoroalkane (HFA-134a) propellants in asthmatics","volume":"151","author":"Ruffin","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.109.3.702_bib13","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/BF01068419","article-title":"A comparison of the two one-sided tests procedure and the power approach for assessing the equivalence of average bioavailability","volume":"15","author":"Schuirman","year":"1987","journal-title":"J Pharmacokinet Biopharm"},{"key":"10.1378\/chest.109.3.702_bib14","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1378\/chest.73.5.568","article-title":"The significance of volumeadjusting the maximal midexpiratory flow in assessing the response to a bronchodilator drug","volume":"73","author":"Sherter","year":"1978","journal-title":"Chest"},{"key":"10.1378\/chest.109.3.702_bib15","doi-asserted-by":"crossref","first-page":"33E","DOI":"10.1016\/0002-9149(90)90250-5","article-title":"Potassium and ventricular arrhythmias","volume":"65","author":"Podrid","year":"1990","journal-title":"Am J Cardiol"},{"key":"10.1378\/chest.109.3.702_bib16","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/S0140-6736(85)92432-8","article-title":"Hypokalaemia induced by inhalation of fenoterol","volume":"1","author":"Haalboom","year":"1985","journal-title":"Lancet"},{"key":"10.1378\/chest.109.3.702_bib17","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1136\/thx.44.2.136","article-title":"Cardiovascular and hypokalaemic effects of inhaled salbutamol, fenoterol and isoprenaline","volume":"44","author":"Crane","year":"1989","journal-title":"Thorax"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001236921545857X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001236921545857X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T01:15:13Z","timestamp":1684199713000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001236921545857X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,3]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1996,3]]}},"alternative-id":["S001236921545857X"],"URL":"https:\/\/doi.org\/10.1378\/chest.109.3.702","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[1996,3]]}}}