{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T20:00:55Z","timestamp":1790539255741,"version":"4.1.0"},"reference-count":20,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[1996,3,1]],"date-time":"1996-03-01T00:00:00Z","timestamp":825638400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chest"],"published-print":{"date-parts":[[1996,3]]},"DOI":"10.1378\/chest.109.3.750","type":"journal-article","created":{"date-parts":[[2008,1,22]],"date-time":"2008-01-22T17:31:17Z","timestamp":1201023077000},"page":"750-755","source":"Crossref","is-referenced-by-count":69,"title":["A Placebo-Controlled Trial of Prostacyclin in Acute Respiratory Failure in COPD"],"prefix":"10.1016","volume":"109","author":[{"given":"Stephen L.","family":"Archer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra","family":"Mike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Crow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walker","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Kenneth","family":"Weir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1378\/chest.109.3.750_bib1","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1056\/NEJM199207093270202","article-title":"An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension","volume":"327","author":"Christman","year":"1992","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.109.3.750_bib2","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1161\/01.CIR.66.2.334","article-title":"Prostacyclin-induced acute pulmonary vasodilation in primary pulmonary hypertension","volume":"66","author":"Rubin","year":"1982","journal-title":"Circulation"},{"key":"10.1378\/chest.109.3.750_bib3","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1016\/0002-8703(85)90013-4","article-title":"A comparison of the acute hemodynamic effects of prostacyclin and hydralazine in primary pulmonary hypertension","volume":"110","author":"Groves","year":"1985","journal-title":"Am Heart J"},{"key":"10.1378\/chest.109.3.750_bib4","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1097\/00000542-199002000-00005","article-title":"Prostacyclin for the treatment of pulmonary hypertension in the adult respiratory distress syndrome: effects on pulmonary capillary pressure and ventilation-perfusion distributions","volume":"72","author":"Radermacher","year":"1990","journal-title":"Anesthesiology"},{"key":"10.1378\/chest.109.3.750_bib5","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1378\/chest.96.4.784","article-title":"Pulmonary vasodilation with prostacyclin in primary and secondary pulmonary hypertension","volume":"96","author":"Jones","year":"1989","journal-title":"Chest"},{"key":"10.1378\/chest.109.3.750_bib6","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/0140-6736(93)92004-D","article-title":"Aerosolised prostacyclin in adult respiratory distress syndrome","volume":"342","author":"Walmrath","year":"1993","journal-title":"Lancet"},{"key":"10.1378\/chest.109.3.750_bib7","series-title":"Cardiac catheterization, angiography and intervention","first-page":"105","article-title":"Blood flow measurement: the cardiac output","author":"Grossman","year":"1991"},{"key":"10.1378\/chest.109.3.750_bib8","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/0140-6736(91)92033-X","article-title":"Inhaled nitric oxide as a cause of selective pulmonary vasodilatation in pulmonary hypertension","volume":"338","author":"Pepka-Zaba","year":"1991","journal-title":"Lancet"},{"key":"10.1378\/chest.109.3.750_bib9","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/0140-6736(92)92686-A","article-title":"Inhaled nitric oxide in persistent pulmonary hypertension of the newborn","volume":"340","author":"Roberts","year":"1992","journal-title":"Lancet"},{"key":"10.1378\/chest.109.3.750_bib10","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1097\/00000542-199303000-00005","article-title":"Inhaled nitric oxide selectively reverses human hypoxic pulmonary vasoconstriction without causing systemic vasodilation","volume":"78","author":"Frostell","year":"1993","journal-title":"Anesthesiology"},{"key":"10.1378\/chest.109.3.750_bib11","doi-asserted-by":"crossref","first-page":"485","DOI":"10.7326\/0003-4819-112-7-485","article-title":"Treatment of primary pulmonary hypertension: results of a randomized trial","volume":"112","author":"Rubin","year":"1990","journal-title":"Ann Intern Med"},{"key":"10.1378\/chest.109.3.750_bib12","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1164\/ajrccm\/140.6.1623","article-title":"The acute administration of vasodilators in primary pulmonary hypertension","volume":"140","author":"Weir","year":"1989","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.109.3.750_bib13","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1161\/01.CIR.83.6.2038","article-title":"Inhaled nitric oxide: a selective pulmonary vasodilator reversing hypoxic pulmonary vasoconstriction","volume":"83","author":"Frostell","year":"1991","journal-title":"Circulation"},{"key":"10.1378\/chest.109.3.750_bib14","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1159\/000129297","article-title":"PGI2 aerosol versus nitric oxide for selective pulmonary vasodilation in hypoxic pulmonary vasoconstriction","volume":"25","author":"Welte","year":"1993","journal-title":"Eur Surg Res"},{"key":"10.1378\/chest.109.3.750_bib15","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1097\/00000542-197906000-00003","article-title":"Ventilation-perfusion and gas exchange effects of sodium nitroprusside in dogs with normal and edematous lungs","volume":"50","author":"Colley","year":"1979","journal-title":"Anesthesiology"},{"key":"10.1378\/chest.109.3.750_bib16","series-title":"The diagnosis and treatment of pulmonary hypertension","first-page":"209","article-title":"Should pulmonary hypertension be treated in chronic obstructive pulmonary disease","author":"Naeije","year":"1992"},{"key":"10.1378\/chest.109.3.750_bib17","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1136\/thx.46.7.504","article-title":"Increased platelet aggregate formation in patients with chronic airflow obstruction and hypoxaemia","volume":"46","author":"Wedzicha","year":"1991","journal-title":"Thorax"},{"key":"10.1378\/chest.109.3.750_bib18","first-page":"191","article-title":"Effects of chronic hypoxia on platelet production in mice","volume":"5","author":"Langdon","year":"1977","journal-title":"Exp Hematol"},{"key":"10.1378\/chest.109.3.750_bib19","doi-asserted-by":"crossref","first-page":"261","DOI":"10.3181\/00379727-197-43253","article-title":"Hypoxia increases erythropoiesis and decreases thrombocytopoiesis in mice: a comparison of two mouse strains","volume":"197","author":"Cottrell","year":"1991","journal-title":"Proc Soc Exp Biol Med"},{"key":"10.1378\/chest.109.3.750_bib20","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1152\/jappl.1989.66.4.1662","article-title":"Effect of dietary fish oil on lung lipid profile and hypoxic pulmonary hypertension","volume":"66","author":"Archer","year":"1989","journal-title":"J Appl Physiol"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215458647?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215458647?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T03:03:37Z","timestamp":1557198217000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369215458647"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,3]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1996,3]]}},"alternative-id":["S0012369215458647"],"URL":"https:\/\/doi.org\/10.1378\/chest.109.3.750","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[1996,3]]}}}