{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T09:03:13Z","timestamp":1759482193744},"reference-count":16,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[1996,3,1]],"date-time":"1996-03-01T00:00:00Z","timestamp":825638400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chest"],"published-print":{"date-parts":[[1996,3]]},"DOI":"10.1378\/chest.109.3.848","type":"journal-article","created":{"date-parts":[[2008,1,22]],"date-time":"2008-01-22T22:31:17Z","timestamp":1201041077000},"page":"848-850","source":"Crossref","is-referenced-by-count":11,"title":["Familial Association of Primary Pulmonary Hypertension and a New Low-Oxygen Affinity \u03b2-Chain Hemoglobinopathy, Hb Washtenaw"],"prefix":"10.1016","volume":"109","author":[{"given":"Richard T.","family":"Wille","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koyamangalath","family":"Krishnan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen A.","family":"Cooney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David S.","family":"Bach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1378\/chest.109.3.848_bib1","first-page":"793","article-title":"Familial primary pulmonary hypertension: clinical patterns","volume":"145","author":"Loyd","year":"1992","journal-title":"Am Rev Respir Disease"},{"key":"10.1378\/chest.109.3.848_bib2","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1161\/01.CIR.42.6.1163","article-title":"Primary pulmonary hypertension","volume":"42","author":"Wagenvoort","year":"1970","journal-title":"Circulation"},{"key":"10.1378\/chest.109.3.848_bib3","first-page":"471a","article-title":"Co-inheritance of a low oxygen affinity hemoglobin, Hb Washtenaw, beta [11(A8) Val?phe] and primary pulmonary hypertension in a Hungarian-American kindred [abstract]","volume":"82","author":"Krishnan","year":"1993","journal-title":"Blood"},{"key":"10.1378\/chest.109.3.848_bib4","doi-asserted-by":"crossref","first-page":"285","DOI":"10.3109\/03630269408996194","article-title":"Hb Washtenaw [a2\u00df211(A8) val?phe]: a new electrophoretically, silent low oxygen affinity variant hemoglobin associated with chronic cyanosis","volume":"18","author":"Krishnan","year":"1994","journal-title":"Hemoglobin"},{"key":"10.1378\/chest.109.3.848_bib5","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/296627a0","article-title":"Linkage of \u00df-thalassaemia mutations and \u00df-globin gene polymorphisms with DNA polymorphisms in human \u00df-globin gene cluster","volume":"296","author":"Orkin","year":"1982","journal-title":"Nature"},{"key":"10.1378\/chest.109.3.848_bib6","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1161\/01.CIR.79.4.863","article-title":"Noninvasive evaluation of pulmonary artery pressure during exercise by salineenhanced Doppler echocardiography in chronic pulmonary disease","volume":"79","author":"Himelman","year":"1989","journal-title":"Circulation"},{"key":"10.1378\/chest.109.3.848_bib7","series-title":"Echocardiography","first-page":"195","article-title":"Hemodynamic information derived from echocardiography","author":"Feigenbaum","year":"1994"},{"key":"10.1378\/chest.109.3.848_bib8","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0733-8619(18)30071-9","article-title":"Genetic anticipation: expanding tandem repeats","volume":"12","author":"Carpenter","year":"1994","journal-title":"Neurol Clin"},{"key":"10.1378\/chest.109.3.848_bib9","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1164\/ajrccm.152.1.7599869","article-title":"Genetic anticipation and abnormal gender ratio at birth in familial primary pulmonary hypertension","volume":"152","author":"Loyd","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.109.3.848_bib10","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1161\/01.CIR.82.3.841","article-title":"Fibrinopeptide A levels indicative of pulmonary vascular thrombosis in patients with primary pulmonary hypertension","volume":"82","author":"Eisenberg","year":"1990","journal-title":"Circulation"},{"key":"10.1378\/chest.109.3.848_bib11","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1164\/ajrccm\/145.4_Pt_1.787","article-title":"Familial pulmonary hypertension: immunogenetic findings in four Caucasian kindreds","volume":"145","author":"Morse","year":"1992","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.109.3.848_bib12","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1164\/ajrccm\/145.4_Pt_1.793","article-title":"Factors influencing the idiopathic development of pulmonary hypertension in the fawn hooded rat","volume":"145","author":"Sato","year":"1992","journal-title":"Am Rev Respir Dis"},{"key":"10.1378\/chest.109.3.848_bib13","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/0002-9343(82)90763-X","article-title":"Pulmonary hypertension and cor pulmonale in the sickle hemoglobinopathies","volume":"73","author":"Collins","year":"1982","journal-title":"Am J Med"},{"key":"10.1378\/chest.109.3.848_bib14","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1111\/j.1600-0609.1972.tb00964.x","article-title":"Fibrosis and carcinoma of the lung in a family with haemoglobin Malmo","volume":"9","author":"Berglund","year":"1972","journal-title":"Scand J Haematol"},{"key":"10.1378\/chest.109.3.848_bib15","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1378\/chest.99.5.1208","article-title":"Familial pulmonary hypertension in association with an abnormal hemoglobin","volume":"99","author":"Rich","year":"1991","journal-title":"Chest"},{"key":"10.1378\/chest.109.3.848_bib16","series-title":"Hemoglobin: molecular, genetic and clinical aspects","author":"Bunn","year":"1986"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215458842?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215458842?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T07:03:45Z","timestamp":1557212625000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369215458842"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,3]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1996,3]]}},"alternative-id":["S0012369215458842"],"URL":"https:\/\/doi.org\/10.1378\/chest.109.3.848","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[1996,3]]}}}