{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T23:55:27Z","timestamp":1784332527484,"version":"3.55.0"},"reference-count":16,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[1996,4,1]],"date-time":"1996-04-01T00:00:00Z","timestamp":828316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chest"],"published-print":{"date-parts":[[1996,4]]},"DOI":"10.1378\/chest.109.4.953","type":"journal-article","created":{"date-parts":[[2008,1,22]],"date-time":"2008-01-22T22:31:17Z","timestamp":1201041077000},"page":"953-956","source":"Crossref","is-referenced-by-count":120,"title":["Inhaled Corticosteroids Do Not Prevent the Development of Tolerance to the Bronchoprotective Effect of Salmeterol"],"prefix":"10.1016","volume":"109","author":[{"given":"Sanjay","family":"Kalra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica A.","family":"Swystun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Bhagat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald W.","family":"Cockcroft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1378\/chest.109.4.953_bib1","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/0954-6111(94)90042-6","article-title":"Reduced protection against exercise induced bronchoconstriction after chronic dosing with salmeterol","volume":"88","author":"Ramage","year":"1994","journal-title":"Respir Med"},{"key":"10.1378\/chest.109.4.953_bib2","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1056\/NEJM199210223271703","article-title":"Long-term effects of a long-acting \u00df2-adrenoceptor agonist, salmeterol, on airway responsiveness in patients with mild asthma","volume":"327","author":"Cheung","year":"1992","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.109.4.953_bib3","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1378\/chest.108.5.1235","article-title":"Rapid onset of tolerance to the bronchoprotective effect of salmeterol","volume":"105","author":"Bhagat","year":"1995","journal-title":"Chest"},{"key":"10.1378\/chest.109.4.953_bib4","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1136\/thx.48.11.1121","article-title":"Changes in methacholine induced bronchoconstriction with the long-acting \u00df2 agonist salmeterol in mild to moderate asthmatic patients","volume":"48","author":"Booth","year":"1993","journal-title":"Thorax"},{"key":"10.1378\/chest.109.4.953_bib5","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.1365-2222.1977.tb01448.x","article-title":"Bronchial reactivity to inhaled histamine: a method and a clinical survey","volume":"7","author":"Cockcroft","year":"1977","journal-title":"Clin Allergy"},{"key":"10.1378\/chest.109.4.953_bib6","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1378\/chest.84.4.505","article-title":"Determination of histamine PC20: comparison of linear and logarithmic interpolation","volume":"84","author":"Cockcroft","year":"1983","journal-title":"Chest"},{"key":"10.1378\/chest.109.4.953_bib7","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1056\/NEJM199210223271704","article-title":"Tolerance to the nonbronchodilator effects of inhaled \u00df2 agonists in asthma","volume":"327","author":"O'Connor","year":"1992","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.109.4.953_bib8","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/0140-6736(93)92695-P","article-title":"Regular inhaled salbutamol and airway responsiveness to allergen","volume":"342","author":"Cockcroft","year":"1993","journal-title":"Lancet"},{"key":"10.1378\/chest.109.4.953_bib9","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/S0091-6749(95)70031-5","article-title":"Regular use of inhaled albuterol and the allergen-induced late asthmatic response","volume":"96","author":"Cockcroft","year":"1995","journal-title":"J Allergy Clin Immunol"},{"key":"10.1378\/chest.109.4.953_bib10","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1056\/NEJM199411103311916","article-title":"Risks of salmeterol","volume":"331","author":"Palmer","year":"1994","journal-title":"N Engl J Med"},{"key":"10.1378\/chest.109.4.953_bib11","doi-asserted-by":"crossref","first-page":"207","DOI":"10.2165\/00003495-199447020-00001","article-title":"Long- versus short-acting \u00df2-agonists: implications for drug therapy","volume":"47","author":"Boulet","year":"1994","journal-title":"Drugs"},{"key":"10.1378\/chest.109.4.953_bib12","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0140-6736(95)91265-7","article-title":"Bronchodilator subsensitivity to salbutamol after twice daily salmeterol in asthmatic patients","volume":"346","author":"Grove","year":"1995","journal-title":"Lancet"},{"key":"10.1378\/chest.109.4.953_bib13","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/clpt.1982.204","article-title":"Reversal of human lymphocyte \u00df-adrenoceptor desentization by glucocorticoids","volume":"32","author":"Hui","year":"1982","journal-title":"Clin Pharmacol Ther"},{"key":"10.1378\/chest.109.4.953_bib14","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1172\/JCI112063","article-title":"Terbutaline-in-duced desensitization of human lymphocyte \u00df2-adrenoceptors: accelerated restoration of \u00df-adrenoceptor responsiveness by prednisolone and ketotifen","volume":"76","author":"Brodde","year":"1985","journal-title":"J Clin Invest"},{"key":"10.1378\/chest.109.4.953_bib15","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1164\/ajrccm.152.5.7582281","article-title":"Interaction of inhaled \u00df2 agonist and inhaled corticosteroid on airway responsiveness to allergen and methacholine","volume":"152","author":"Cockcroft","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1378\/chest.109.4.953_bib16","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/0140-6736(90)93098-A","article-title":"Regular inhaled beta-agonist treatment in bronchial asthma","volume":"336","author":"Sears","year":"1990","journal-title":"Lancet"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215460283?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369215460283?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T11:20:22Z","timestamp":1546341622000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369215460283"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,4]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1996,4]]}},"alternative-id":["S0012369215460283"],"URL":"https:\/\/doi.org\/10.1378\/chest.109.4.953","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[1996,4]]}}}