{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T21:28:08Z","timestamp":1774474088798,"version":"3.50.1"},"reference-count":24,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chest"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1378\/chest.11-0245","type":"journal-article","created":{"date-parts":[[2011,6,10]],"date-time":"2011-06-10T08:48:51Z","timestamp":1307695731000},"page":"36-42","source":"Crossref","is-referenced-by-count":50,"title":["The Effect of Diluent pH on Bloodstream Infection Rates in Patients Receiving IV Treprostinil for Pulmonary Arterial Hypertension"],"prefix":"10.1016","volume":"141","author":[{"given":"Jonathan D.","family":"Rich","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cherylanne","family":"Glassner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Wade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Coslet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl","family":"Arneson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aimee","family":"Doran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mardi","family":"Gomberg-Maitland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1378\/chest.11-0245_bib1","doi-asserted-by":"crossref","first-page":"216","DOI":"10.7326\/0003-4819-107-2-216","article-title":"Primary pulmonary hypertension. A national prospective study","volume":"107","author":"Rich","year":"1987","journal-title":"Ann Intern Med"},{"issue":"5","key":"10.1378\/chest.11-0245_bib2","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1056\/NEJM199602013340504","article-title":"A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension","volume":"334","author":"Barst","year":"1996","journal-title":"N Engl J Med"},{"issue":"12","key":"10.1378\/chest.11-0245_bib3","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1161\/01.CIR.0000029100.82385.58","article-title":"Survival in primary pulmonary hypertension: the impact of epoprostenol therapy","volume":"106","author":"McLaughlin","year":"2002","journal-title":"Circulation"},{"issue":"4","key":"10.1378\/chest.11-0245_bib4","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/S0735-1097(02)02012-0","article-title":"Long-term intravenous epoprostenol infusion in primary pulmonary hypertension: prognostic factors and survival","volume":"40","author":"Sitbon","year":"2002","journal-title":"J Am Coll Cardiol"},{"issue":"8","key":"10.1378\/chest.11-0245_bib5","first-page":"170","article-title":"Bloodstream infections among patients treated with intravenous epoprostenol or intravenous treprostinil for pulmonary arterial hypertension\u2014seven sites, United States, 2003-2006","volume":"56","author":"Centers for Disease Control and Prevention (CDC)","year":"2007","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"4","key":"10.1378\/chest.11-0245_bib6","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1086\/529552","article-title":"Bloodstream infections in patients given treatment with intravenous prostanoids","volume":"29","author":"Kallen","year":"2008","journal-title":"Infect Control Hosp Epidemiol"},{"issue":"1","key":"10.1378\/chest.11-0245_bib7","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1378\/chest.126.1.90","article-title":"Micrococcus-associated central venous catheter infection in patients with pulmonary arterial hypertension","volume":"126","author":"Oudiz","year":"2004","journal-title":"Chest"},{"issue":"20","key":"10.1378\/chest.11-0245_bib8","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1001\/jama.1994.03510440058033","article-title":"Nosocomial bloodstream infection in critically ill patients. Excess length of stay, extra costs, and attributable mortality","volume":"271","author":"Pittet","year":"1994","journal-title":"JAMA"},{"issue":"1","key":"10.1378\/chest.11-0245_bib9","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1378\/chest.100.1.164","article-title":"Excess mortality in critically ill patients with nosocomial bloodstream infections","volume":"100","author":"Smith","year":"1991","journal-title":"Chest"},{"issue":"12","key":"10.1378\/chest.11-0245_bib10","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1164\/rccm.200505-766OC","article-title":"Transition from intravenous epoprostenol to intravenous treprostinil in pulmonary hypertension","volume":"172","author":"Gomberg-Maitland","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"10.1378\/chest.11-0245_bib11","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1097\/00005344-200302000-00019","article-title":"Efficacy and safety of treprostinil: an epoprostenol analog for primary pulmonary hypertension","volume":"41","author":"McLaughlin","year":"2003","journal-title":"J Cardiovasc Pharmacol"},{"issue":"4","key":"10.1378\/chest.11-0245_bib12","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1183\/09031936.00097107","article-title":"Prostacyclin therapies for the treatment of pulmonary arterial hypertension","volume":"31","author":"Gomberg-Maitland","year":"2008","journal-title":"Eur Respir J"},{"issue":"7","key":"10.1378\/chest.11-0245_bib13","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1111\/j.1742-1241.2009.02307.x","article-title":"Stability and antimicrobial effectiveness of treprostinil sodium in Sterile Diluent for Flolan","volume":"64","author":"Zaccardelli","year":"2010","journal-title":"Int J Clin Pract"},{"key":"10.1378\/chest.11-0245_bib14","series-title":"Remodulin [package insert]","year":"2008"},{"key":"10.1378\/chest.11-0245_bib15","series-title":"Flolan [package insert]","year":"2008"},{"issue":"6","key":"10.1378\/chest.11-0245_bib16","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1183\/09031936.00042107","article-title":"A USA-based registry for pulmonary arterial hypertension: 1982-2006","volume":"30","author":"Thenappan","year":"2007","journal-title":"Eur Respir J"},{"issue":"160","key":"10.1378\/chest.11-0245_bib17","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1742-1241.2008.01811.x","article-title":"Guidelines for the prevention of central venous catheter-related blood stream infections with prostanoid therapy for pulmonary arterial hypertension","author":"Doran","year":"2008","journal-title":"Int J Clin Pract Suppl"},{"issue":"14","key":"10.1378\/chest.11-0245_bib18","first-page":"1","article-title":"Deaths: final data for 2006","volume":"57","author":"Heron","year":"2009","journal-title":"Natl Vital Stat Rep"},{"issue":"4","key":"10.1378\/chest.11-0245_bib19","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1253\/circj.71.559","article-title":"Prevention of catheter-related infections using a closed hub system in patients with pulmonary arterial hypertension","volume":"71","author":"Akagi","year":"2007","journal-title":"Circ J"},{"issue":"11","key":"10.1378\/chest.11-0245_bib20","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1007\/s10096-003-1024-1","article-title":"Micrococcus infection in patients receiving epoprostenol by continuous infusion","volume":"22","author":"Yap","year":"2003","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"9","key":"10.1378\/chest.11-0245_bib21","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.ajic.2008.08.001","article-title":"National Healthcare Safety Network (NHSN) report, data summary for 2006 through 2007, issued November 2008","volume":"36","author":"Edwards","year":"2008","journal-title":"Am J Infect Control"},{"issue":"9","key":"10.1378\/chest.11-0245_bib22","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.4065\/81.9.1159","article-title":"The risk of bloodstream infection in adults with different intravascular devices: a systematic review of 200 published prospective studies","volume":"81","author":"Maki","year":"2006","journal-title":"Mayo Clin Proc"},{"issue":"9","key":"10.1378\/chest.11-0245_bib23","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1093\/ajhp\/60.9.916","article-title":"Stability and preservative effectiveness of treprostinil sodium after dilution in common intravenous diluents","volume":"60","author":"Phares","year":"2003","journal-title":"Am J Health Syst Pharm"},{"issue":"9","key":"10.1378\/chest.11-0245_bib24","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1086\/605320","article-title":"Closed-hub systems with protected connections and the reduction of risk of catheter-related bloodstream infection in pediatric patients receiving intravenous prostanoid therapy for pulmonary hypertension","volume":"30","author":"Ivy","year":"2009","journal-title":"Infect Control Hosp Epidemiol"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369212600117?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369212600117?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T03:35:57Z","timestamp":1614915357000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369212600117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["S0012369212600117"],"URL":"https:\/\/doi.org\/10.1378\/chest.11-0245","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[2012,1]]}}}