{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:15:20Z","timestamp":1790950520439,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journal.chestnet.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chest"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1378\/chest.11-3157","type":"journal-article","created":{"date-parts":[[2012,4,5]],"date-time":"2012-04-05T22:17:59Z","timestamp":1333664279000},"page":"63-75","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":237,"title":["Predictive Value of Interferon-\u03b3 Release Assays and Tuberculin Skin Testing for Progression From Latent TB Infection to Disease State"],"prefix":"10.1016","volume":"142","author":[{"given":"Roland","family":"Diel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Loddenkemper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Nienhaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1378\/chest.11-3157_bib1","series-title":"2011\/2012 Tuberculosis Global Facts","author":"World Health Organization","year":"2011"},{"issue":"2","key":"10.1378\/chest.11-3157_bib2","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1093\/oxfordjournals.aje.a121593","article-title":"The prognosis of a positive tuberculin reaction in childhood and adolescence","volume":"99","author":"Comstock","year":"1974","journal-title":"Am J Epidemiol"},{"issue":"23","key":"10.1378\/chest.11-3157_bib3","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1098\/rsif.2007.1138","article-title":"Eliminating human tuberculosis in the twenty-first century","volume":"5","author":"Dye","year":"2008","journal-title":"J R Soc Interface"},{"issue":"33","key":"10.1378\/chest.11-3157_bib4","doi-asserted-by":"crossref","first-page":"13980","DOI":"10.1073\/pnas.0901720106","article-title":"Epidemiological benefits of more-effective tuberculosis vaccines, drugs, and diagnostics","volume":"106","author":"Abu-Raddad","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"10.1378\/chest.11-3157_bib5","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1378\/chest.09-2350","article-title":"Evidence-based comparison of commercial interferon-gamma release assays for detecting active TB: a metaanalysis","volume":"137","author":"Diel","year":"2010","journal-title":"Chest"},{"issue":"1","key":"10.1378\/chest.11-3157_bib6","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1183\/09031936.00115110","article-title":"Interferon-\u03b3 release assays for the diagnosis of latent Mycobacterium tuberculosis infection: a systematic review and meta-analysis","volume":"37","author":"Diel","year":"2011","journal-title":"Eur Respir J"},{"issue":"1","key":"10.1378\/chest.11-3157_bib7","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1183\/09031936.00114810","article-title":"Interferon-\u03b3 release assays for the diagnosis of active tuberculosis: a systematic review and meta-analysis","volume":"37","author":"Sester","year":"2011","journal-title":"Eur Respir J"},{"issue":"1","key":"10.1378\/chest.11-3157_bib8","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S1473-3099(11)70210-9","article-title":"Predictive value of interferon-gamma release assays for incident active tuberculosis: a systematic review and meta-analysis","volume":"12","author":"Rangaka","year":"2012","journal-title":"Lancet Infect Dis"},{"issue":"7","key":"10.1378\/chest.11-3157_bib9","doi-asserted-by":"crossref","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS Med"},{"key":"10.1378\/chest.11-3157_bib10","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1471-2288-3-25","article-title":"The development of QUADAS: a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews","volume":"3","author":"Whiting","year":"2003","journal-title":"BMC Med Res Methodol"},{"issue":"2","key":"10.1378\/chest.11-3157_bib11","first-page":"CD001363","article-title":"Isoniazid for preventing tuberculosis in non-HIV infected persons","author":"Smieja","year":"2000","journal-title":"Cochrane Database Syst Rev"},{"issue":"RR-6","key":"10.1378\/chest.11-3157_bib12","first-page":"1","article-title":"Targeted tuberculin testing and treatment of latent tuberculosis infection","volume":"49","author":"American Thoracic Society","year":"2000","journal-title":"MMWR Recomm Rep"},{"issue":"2","key":"10.1378\/chest.11-3157_bib13","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/s15010-008-8082-3","article-title":"High prevalence of latent tuberculosis infection in patients in end-stage renal disease on hemodialysis: comparison of QuantiFERON-TB GOLD, ELISPOT, and tuberculin skin test","volume":"37","author":"Lee","year":"2009","journal-title":"Infection"},{"issue":"6","key":"10.1378\/chest.11-3157_bib14","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1183\/09031936.00098509","article-title":"Predictive value for progression to tuberculosis by IGRA and TST in immigrant contacts","volume":"35","author":"Kik","year":"2010","journal-title":"Eur Respir J"},{"issue":"2","key":"10.1378\/chest.11-3157_bib15","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1128\/JCM.40.2.704-706.2002","article-title":"Immune responses to the Mycobacterium tuberculosis-specific antigen ESAT-6 signal subclinical infection among contacts of tuberculosis patients","volume":"40","author":"Doherty","year":"2002","journal-title":"J Clin Microbiol"},{"issue":"11","key":"10.1378\/chest.11-3157_bib16","doi-asserted-by":"crossref","first-page":"777","DOI":"10.7326\/0003-4819-149-11-200812020-00248","article-title":"Prognostic value of a T-cell-based, interferon-gamma biomarker in children with tuberculosis contact","volume":"149","author":"Bakir","year":"2008","journal-title":"Ann Intern Med"},{"issue":"1","key":"10.1378\/chest.11-3157_bib17","doi-asserted-by":"crossref","first-page":"e1379","DOI":"10.1371\/journal.pone.0001379","article-title":"Incidence of tuberculosis and the predictive value of ELISPOT and Mantoux tests in Gambian case contacts","volume":"3","author":"Hill","year":"2008","journal-title":"PLoS ONE"},{"issue":"12","key":"10.1378\/chest.11-3157_bib18","doi-asserted-by":"crossref","first-page":"e8257","DOI":"10.1371\/journal.pone.0008257","article-title":"IFNgamma response to Mycobacterium tuberculosis, risk of infection and disease in household contacts of tuberculosis patients in Colombia","volume":"4","author":"del Corral","year":"2009","journal-title":"PLoS ONE"},{"issue":"5","key":"10.1378\/chest.11-3157_bib19","doi-asserted-by":"crossref","first-page":"e10508","DOI":"10.1371\/journal.pone.0010508","article-title":"Evaluation of the prognostic value of IFN-gamma release assay and tuberculin skin test in household contacts of infectious tuberculosis cases in Senegal [published correction appears in PLoS One","volume":"5","author":"Lienhardt","year":"2010","journal-title":"PLoS ONE"},{"issue":"1","key":"10.1378\/chest.11-3157_bib20","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/j.1440-1843.2006.01000.x","article-title":"Use of QuantiFERON-TB Gold to investigate tuberculosis contacts in a high school","volume":"12","author":"Higuchi","year":"2007","journal-title":"Respirology"},{"issue":"5","key":"10.1378\/chest.11-3157_bib21","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.jinf.2009.02.019","article-title":"Contact investigation in a primary school using a whole blood interferon-gamma assay","volume":"58","author":"Higuchi","year":"2009","journal-title":"J Infect"},{"issue":"7","key":"10.1378\/chest.11-3157_bib22","first-page":"819","article-title":"Use of the QuantiFERON-TB Gold test for screening tuberculosis contacts and predicting active disease","volume":"14","author":"Yoshiyama","year":"2010","journal-title":"Int J Tuberc Lung Dis"},{"issue":"12","key":"10.1378\/chest.11-3157_bib23","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.clinbiochem.2007.04.006","article-title":"Use of an interferon-gamma based assay to assess bladder cancer patients treated with intravesical BCG and exposed to tuberculosis","volume":"40","author":"Silverman","year":"2007","journal-title":"Clin Biochem"},{"issue":"7","key":"10.1378\/chest.11-3157_bib24","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1086\/597351","article-title":"Detection and prediction of active tuberculosis disease by a whole-blood interferon-gamma release assay in HIV-1-infected individuals","volume":"48","author":"Aichelburg","year":"2009","journal-title":"Clin Infect Dis"},{"issue":"suppl 4","key":"10.1378\/chest.11-3157_bib25","doi-asserted-by":"crossref","first-page":"A148","DOI":"10.1136\/thx.2010.151043.17","article-title":"QuantiFERON testing in close contacts of smear positive pulmonary TB identifies people at low risk of secondary progression","volume":"65","author":"Haldar","year":"2010","journal-title":"Thorax"},{"issue":"6","key":"10.1378\/chest.11-3157_bib26","doi-asserted-by":"crossref","first-page":"e20770","DOI":"10.1371\/journal.pone.0020770","article-title":"The role of the interferon gamma release assay in assessing recent tuberculosis transmission in a hospital incident","volume":"6","author":"Bradshaw","year":"2011","journal-title":"PLoS ONE"},{"issue":"1","key":"10.1378\/chest.11-3157_bib27","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1164\/rccm.201006-0974OC","article-title":"Negative and positive predictive value of a whole-blood interferon-\u03b3 release assay for developing active tuberculosis:an update","volume":"183","author":"Diel","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"issue":"9","key":"10.1378\/chest.11-3157_bib28","first-page":"1209","article-title":"Predictive values of QuantiFERON-TB Gold testing in screening for tuberculosis disease in asylum seekers","volume":"14","author":"Harstad","year":"2010","journal-title":"Int J Tuberc Lung Dis"},{"issue":"6","key":"10.1378\/chest.11-3157_bib29","doi-asserted-by":"crossref","first-page":"e1522","DOI":"10.1542\/peds.2010-0885","article-title":"Malnutrition and helminth infection affect performance of an interferon gamma-release assay","volume":"126","author":"Thomas","year":"2010","journal-title":"Pediatrics"},{"issue":"12","key":"10.1378\/chest.11-3157_bib30","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1007\/s10067-011-1771-9","article-title":"Interferon-\u03b3 release assay in the diagnosis of latent tuberculosis infection in arthritis patients treated with tumor necrosis factor antagonists in Korea","volume":"30","author":"Chang","year":"2011","journal-title":"Clin Rheumatol"},{"issue":"3","key":"10.1378\/chest.11-3157_bib31","doi-asserted-by":"crossref","first-page":"e17984","DOI":"10.1371\/journal.pone.0017984","article-title":"The tuberculin skin test versus QuantiFERON TB Gold\u00ae in predicting tuberculosis disease in an adolescent cohort study in South Africa","volume":"6","author":"Mahomed","year":"2011","journal-title":"PLoS ONE"},{"issue":"1","key":"10.1378\/chest.11-3157_bib32","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.diagmicrobio.2010.09.005","article-title":"Detection of latent tuberculosis by the tuberculin skin test and a whole-blood interferon-\u03b3 release assay, and the development of active tuberculosis in HIV-seropositive persons","volume":"69","author":"Santin","year":"2011","journal-title":"Diagn Microbiol Infect Dis"},{"key":"10.1378\/chest.11-3157_bib33","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1186\/1471-2334-11-245","article-title":"Specificity of a whole blood IGRA in German nursing students","volume":"11","author":"Schablon","year":"2011","journal-title":"BMC Infect Dis"},{"issue":"4","key":"10.1378\/chest.11-3157_bib34","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1378\/chest.11-1158","article-title":"Performance of confirmatory interferon-gamma release assay in school tuberculosis outbreaks","volume":"141","author":"Song","year":"2012","journal-title":"Chest"},{"issue":"6","key":"10.1378\/chest.11-3157_bib35","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1183\/09031936.00053809","article-title":"Tuberculosis screening in Portuguese healthcare workers using the tuberculin skin test and the interferon-gamma release assay","volume":"34","author":"Torres Costa","year":"2009","journal-title":"Eur Respir J"},{"issue":"2","key":"10.1378\/chest.11-3157_bib36","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/j.1365-2249.2007.03477.x","article-title":"Tuberculosis antigen-specific immune responses can be detected using enzyme-linked immunospot technology in human immunodeficiency virus (HIV)-1 patients with advanced disease","volume":"150","author":"Clark","year":"2007","journal-title":"Clin Exp Immunol"},{"issue":"12","key":"10.1378\/chest.11-3157_bib37","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1086\/657411","article-title":"Latent tuberculosis detection by interferon \u03b3 release assay during pregnancy predicts active tuberculosis and mortality in human immunodeficiency virus type 1-infected women and their children","volume":"202","author":"Jonnalagadda","year":"2010","journal-title":"J Infect Dis"},{"issue":"6","key":"10.1378\/chest.11-3157_bib38","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1164\/rccm.200912-1875OC","article-title":"T-Spot.TB outperforms tuberculin skin test in predicting tuberculosis disease","volume":"182","author":"Leung","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"issue":"9","key":"10.1378\/chest.11-3157_bib39","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1111\/j.1600-6143.2011.03625.x","article-title":"A prospective longitudinal study evaluating the usefulness of a T-cell-based assay for latent tuberculosis infection in kidney transplant recipients","volume":"11","author":"Kim","year":"2011","journal-title":"Am J Transplant"},{"issue":"9","key":"10.1378\/chest.11-3157_bib40","first-page":"1117","article-title":"Longitudinal observation of an interferon gamma-released assay (T-SPOT.TB) for Mycobacterium tuberculosis infection in AIDS patients on highly active antiretroviral therapy","volume":"123","author":"Zhang","year":"2010","journal-title":"Chin Med J (Engl)"},{"issue":"23","key":"10.1378\/chest.11-3157_bib41","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1056\/NEJMcp021045","article-title":"Clinical practice. Latent tuberculosis infection","volume":"347","author":"Jasmer","year":"2002","journal-title":"N Engl J Med"}],"container-title":["Chest"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369212603900?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012369212603900?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T06:31:46Z","timestamp":1757917906000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012369212603900"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["S0012369212603900"],"URL":"https:\/\/doi.org\/10.1378\/chest.11-3157","relation":{},"ISSN":["0012-3692"],"issn-type":[{"value":"0012-3692","type":"print"}],"subject":[],"published":{"date-parts":[[2012,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Predictive Value of Interferon-\u03b3 Release Assays and Tuberculin Skin Testing for Progression From Latent TB Infection to Disease State","name":"articletitle","label":"Article Title"},{"value":"Chest","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1378\/chest.11-3157","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 The American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}